PMID- 30039563
OWN - NLM
STAT- MEDLINE
DCOM- 20190318
LR  - 20190318
IS  - 1753-0407 (Electronic)
IS  - 1753-0407 (Linking)
VI  - 11
IP  - 2
DP  - 2019 Feb
TI  - Altered brain structural topological properties in type 2 diabetes mellitus 
      patients without complications.
PG  - 129-138
LID - 10.1111/1753-0407.12826 [doi]
AB  - BACKGROUND: Type 2 diabetes mellitus (T2DM) is a risk factor for cognitive 
      dysfunction, and white matter (WM) microstructural impairments play a critical 
      role in T2DM-related cognitive decline. Disruptions to the WM have been detected 
      in T2DM patients before clinical diagnosis of cognitive dysfunction. Herein, we 
      investigated changes in brain structural topological properties and their 
      correlation with behavior in T2DM patients without complications. METHODS: 
      Diffusion tensor imaging (DTI) structural network topological analysis was 
      performed on T2DM patients and healthy controls. Intergroup differences in global 
      and nodal parameters were analyzed, and correlations between the network 
      parameters and behavioral performance were tested. RESULTS: Type 2 diabetes 
      mellitus patients exhibited preserved small-world properties, but altered nodal 
      properties, including decreased efficiency in the right hippocampus, right 
      amygdala, left pallidum, left postcentral gyrus, and right pole of the superior 
      temporal gyrus, and increased degree in the right inferior frontal gyrus. 
      Correlations were also found between the altered global and nodal parameters and 
      behavioral performance. CONCLUSIONS: The results verified the existence of WM 
      structural network changes and the association between structural properties and 
      cognitive state in T2DM patients before the occurrence of complications. Research 
      of structural properties may contribute to our understanding of the intrinsic 
      links between T2DM and cognition.
CI  - (c) 2018 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and John 
      Wiley & Sons Australia, Ltd.
FAU - Zhang, Yang
AU  - Zhang Y
AD  - Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin 
      Medical University General Hospital, Tianjin, China.
FAU - Cao, Yujuan
AU  - Cao Y
AD  - Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin 
      Medical University General Hospital, Tianjin, China.
FAU - Xie, Yingjie
AU  - Xie Y
AD  - Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin 
      Medical University General Hospital, Tianjin, China.
FAU - Liu, Linlin
AU  - Liu L
AD  - Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin 
      Medical University General Hospital, Tianjin, China.
FAU - Qin, Wen
AU  - Qin W
AD  - Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin 
      Medical University General Hospital, Tianjin, China.
FAU - Lu, Shan
AU  - Lu S
AD  - Department of Radiology, Tianjin Medical University Metabolic Diseases Hospital, 
      Tianjin, China.
FAU - Zhang, Quan
AU  - Zhang Q
AD  - Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin 
      Medical University General Hospital, Tianjin, China.
LA  - eng
GR  - 17JCZDJC36300/Natural Science Foundation of Tianjin, China/
PT  - Journal Article
DEP - 20180819
PL  - Australia
TA  - J Diabetes
JT  - Journal of diabetes
JID - 101504326
SB  - IM
MH  - Adult
MH  - Brain/*diagnostic imaging/pathology/*physiopathology
MH  - Cognition/physiology
MH  - Diabetes Mellitus, Type 2/*physiopathology
MH  - Diffusion Tensor Imaging/*methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nerve Net/diagnostic imaging/physiopathology
MH  - White Matter/diagnostic imaging/pathology/physiopathology
OTO - NOTNLM
OT  - 2型糖尿病
OT  - diffusion tensor imaging
OT  - graph theory
OT  - type 2 diabetes mellitus
OT  - 图论
OT  - 弥散张量成像
EDAT- 2018/07/25 06:00
MHDA- 2019/03/19 06:00
CRDT- 2018/07/25 06:00
PHST- 2018/03/31 00:00 [received]
PHST- 2018/06/19 00:00 [revised]
PHST- 2018/07/13 00:00 [accepted]
PHST- 2018/07/25 06:00 [pubmed]
PHST- 2019/03/19 06:00 [medline]
PHST- 2018/07/25 06:00 [entrez]
AID - 10.1111/1753-0407.12826 [doi]
PST - ppublish
SO  - J Diabetes. 2019 Feb;11(2):129-138. doi: 10.1111/1753-0407.12826. Epub 2018 Aug 
      19.