PMID- 30039879
OWN - NLM
STAT- MEDLINE
DCOM- 20190107
LR  - 20190107
IS  - 1600-0560 (Electronic)
IS  - 0303-6987 (Linking)
VI  - 45
IP  - 11
DP  - 2018 Nov
TI  - Evidence behind the use of molecular tests in melanocytic lesions and practice 
      patterns of these tests by dermatopathologists.
PG  - 839-846
LID - 10.1111/cup.13327 [doi]
AB  - BACKGROUND: The gold standard for the diagnosis of melanocytic lesions is 
      histologic examination. However, as histologic examination can have its 
      limitations, there are many clinical scenarios in which additional testing may be 
      appropriate in an attempt to render a definitive diagnosis. METHODS: A literature 
      review for three ancillary tests-comparative genomic hybridization 
      (CGH)/single-nucleotide polymorphism (SNP) array, fluorescence in situ 
      hybridization (FISH), and gene expression profiling by quantitative reverse 
      transcription polymerase chain reaction (qRT-PCR)-was compiled and current use 
      patterns were tabulated. Survey of the practice patterns of these tests by 
      dermatopathologists was also accessed in the attendees of the American Society of 
      Dermatopathology Annual Meeting (Chicago, 2016). RESULTS: Here we summarize the 
      use of these molecular tests in melanocytic lesions. We found that 54.4% of the 
      respondents surveyed utilize (or expect consultants to utilize) molecular testing 
      of melanocytic lesions in their practice when appropriate. CONCLUSIONS: CGH/SNP 
      arrays, FISH testing, and qRT-PCR applied to melanocytic lesions have allowed for 
      more accurate classification. Just over half of those surveyed use molecular 
      testing for melanocytic lesion with the majority sending their cases out for 
      completion of the molecular test.
CI  - (c) 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Emanuel, Patrick O
AU  - Emanuel PO
AUID- ORCID: 0000-0003-1068-6969
AD  - Departamento de Patologia, Clinica Ricardo Palma, Lima, Peru.
FAU - Andea, Aleodor A
AU  - Andea AA
AD  - Departments of Dermatology and Pathology, University of Michigan Medical Center, 
      Ann Arbor, Michigan.
FAU - Vidal, Claudia I
AU  - Vidal CI
AUID- ORCID: 0000-0003-2672-4974
AD  - Departments of Dermatology and Pathology, Saint Louis University School of 
      Medicine, St. Louis, Missouri.
FAU - Missall, Tricia A
AU  - Missall TA
AUID- ORCID: 0000-0001-9062-0606
AD  - Departments of Dermatology and Pathology, Saint Louis University School of 
      Medicine, St. Louis, Missouri.
FAU - Novoa, Roberto A
AU  - Novoa RA
AD  - Departments of Dermatology and Pathology, Stanford University School of Medicine, 
      Stanford, California.
FAU - Bohlke, Angela K
AU  - Bohlke AK
AD  - Silver Falls Dermatology, Salem, Oregon.
FAU - Hughes, Sarah R
AU  - Hughes SR
AD  - Department of Pathology, Gundersen Health System, La Crosse, Wisconsin.
FAU - Hurley, Maria Y
AU  - Hurley MY
AUID- ORCID: 0000-0002-1162-7250
AD  - Departments of Dermatology and Pathology, Saint Louis University School of 
      Medicine, St. Louis, Missouri.
FAU - Kim, Jinah
AU  - Kim J
AUID- ORCID: 0000-0002-5065-5916
AD  - Departments of Dermatology and Pathology, Stanford University School of Medicine, 
      Stanford, California.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180822
PL  - United States
TA  - J Cutan Pathol
JT  - Journal of cutaneous pathology
JID - 0425124
SB  - IM
MH  - Comparative Genomic Hybridization
MH  - Dermatology/methods
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Melanoma/*diagnosis/genetics
MH  - Molecular Diagnostic Techniques/*methods
MH  - Pathology/methods
MH  - Practice Patterns, Physicians'/*statistics & numerical data
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Skin Neoplasms/*diagnosis/genetics
OTO - NOTNLM
OT  - chain reaction
OT  - comparative genomic hybridization
OT  - fluorescence in situ hybridization
OT  - gene expression profiling by quantitative reverse transcription polymerase
OT  - melanocytic lesions
OT  - single-nucleotide polymorphism
EDAT- 2018/07/25 06:00
MHDA- 2019/01/08 06:00
CRDT- 2018/07/25 06:00
PHST- 2017/10/25 00:00 [received]
PHST- 2018/06/24 00:00 [revised]
PHST- 2018/07/05 00:00 [accepted]
PHST- 2018/07/25 06:00 [pubmed]
PHST- 2019/01/08 06:00 [medline]
PHST- 2018/07/25 06:00 [entrez]
AID - 10.1111/cup.13327 [doi]
PST - ppublish
SO  - J Cutan Pathol. 2018 Nov;45(11):839-846. doi: 10.1111/cup.13327. Epub 2018 Aug 
      22.