PMID- 30039987
OWN - NLM
STAT- MEDLINE
DCOM- 20190829
LR  - 20211204
IS  - 1744-4160 (Electronic)
IS  - 1381-3455 (Linking)
VI  - 125
IP  - 4
DP  - 2019 Oct
TI  - Endoplasmic reticulum stress in the livers of BDNF heterozygous knockout mice.
PG  - 378-386
LID - 10.1080/13813455.2018.1489850 [doi]
AB  - Context: Involvement of endoplasmic reticulum (ER) stress and brain-derived 
      neurotrophic factor (BDNF) in hepatic lipid metabolism has been reported 
      previously. Objective: The effects of chronic BDNF deficiency on ER stress 
      response in the livers were examined in this study. Methods: BDNF((+/-)) mice, 
      characterised by BDNF deficiency, and their wild-type (WT) littermates were used. 
      The ER stress was induced by tunicamycin (Tm) (0.5 mg/kg, intraperitoneal). 
      Animals were divided into four groups; WT, WT + Tm, BDNF((+/-)), and 
      BDNF((+/-))+Tm. Results: At the basal conditions, BDNF deficiency did not affect 
      hepatic cell death or lipid accumulation. However, during ER stress, 
      BDNF((+/-))+Tm group showed increased apoptosis, GADD153 immunostaining, sterol 
      regulatory element-binding protein-1c (SREBP-1c) level, and steatosis compared to 
      the WT + Tm group. Conclusion: Endogenous BDNF might be protective against 
      apoptosis through GADD153 suppression and steatosis via SREBP-1c suppression 
      during ER stress. This effect of BDNF might be clinically important for type 2 
      diabetes and obesity, which are related with both ER stress and BDNF deficiency.
FAU - Cirrik, Selma
AU  - Cirrik S
AUID- ORCID: 0000-0001-8474-0185
AD  - a Department of Physiology, Faculty of Medicine, Ordu University , Ordu , Turkey.
FAU - Hacioglu, Gulay
AU  - Hacioglu G
AD  - b Department of Physiology, Faculty of Medicine, Giresun University , Giresun , 
      Turkey.
FAU - Abidin, Ismail
AU  - Abidin I
AD  - c Department of Biophysics, Faculty of Medicine, Karadeniz Technical University , 
      Trabzon , Turkey.
FAU - Aydin-Abidin, Selcen
AU  - Aydin-Abidin S
AD  - c Department of Biophysics, Faculty of Medicine, Karadeniz Technical University , 
      Trabzon , Turkey.
FAU - Noyan, Tevfik
AU  - Noyan T
AD  - d Department of Medical Biochemistry, Faculty of Medicine, Ordu University , Ordu 
      , Turkey.
LA  - eng
PT  - Journal Article
DEP - 20180724
PL  - England
TA  - Arch Physiol Biochem
JT  - Archives of physiology and biochemistry
JID - 9510153
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Endoplasmic Reticulum Chaperone BiP)
RN  - 0 (Heat-Shock Proteins)
RN  - 0 (PPAR alpha)
RN  - 147336-12-7 (Transcription Factor CHOP)
RN  - EC 3.4.22.- (Caspase 12)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/blood/*drug effects/*genetics
MH  - Caspase 12/metabolism
MH  - Endoplasmic Reticulum Chaperone BiP
MH  - Endoplasmic Reticulum Stress/*genetics
MH  - Heat-Shock Proteins/metabolism
MH  - *Heterozygote
MH  - Liver/*cytology/*metabolism
MH  - Mice
MH  - Mice, Knockout
MH  - PPAR alpha/metabolism
MH  - Transcription Factor CHOP/metabolism
OTO - NOTNLM
OT  - BDNF heterozygous knockout mice
OT  - SREBP-1c
OT  - apoptosis
OT  - endoplasmic reticulum stress
OT  - steatosis
EDAT- 2018/07/25 06:00
MHDA- 2019/08/30 06:00
CRDT- 2018/07/25 06:00
PHST- 2018/07/25 06:00 [pubmed]
PHST- 2019/08/30 06:00 [medline]
PHST- 2018/07/25 06:00 [entrez]
AID - 10.1080/13813455.2018.1489850 [doi]
PST - ppublish
SO  - Arch Physiol Biochem. 2019 Oct;125(4):378-386. doi: 
      10.1080/13813455.2018.1489850. Epub 2018 Jul 24.