PMID- 30040410
OWN - NLM
STAT- MEDLINE
DCOM- 20180820
LR  - 20181202
IS  - 1520-5118 (Electronic)
IS  - 0021-8561 (Linking)
VI  - 66
IP  - 31
DP  - 2018 Aug 8
TI  - Clostridium butyricum Attenuates Chronic Unpredictable Mild Stress-Induced 
      Depressive-Like Behavior in Mice via the Gut-Brain Axis.
PG  - 8415-8421
LID - 10.1021/acs.jafc.8b02462 [doi]
AB  - Abnormal gut microbiome has been associated with depression. The mechanism of 
      probiotics against depression remains unclear. This study aimed to determine 
      whether Clostridium butyricum (Cb) could attenuate chronic unpredictable mild 
      stress-induced depressive-like behavior and its possible mechanisms. Male C57BL/6 
      mice were subjected to chronic unpredictable mild stress (CUMS) and were treated 
      with Cb. Depressive-like behavior was evaluated by a series of behavioral tests. 
      The levels of cerebral 5-hydroxytryptamine (5-HT), brain derived neurotrophic 
      factor (BDNF), glucagon-like peptide-1 (GLP-1) receptor and intestinal were 
      measured. Cb treatment significantly improved CUMS-induced depressive-like 
      behavior in mice. Meanwhile, Cb treatment exhibited prominent effects, increasing 
      5-HT and GLP-1 and upregulating BDNF expression. Furthermore, Cb-treated mice 
      showed increased secretion of GLP-1 and upregulated GLP-1R expression. Taken 
      together, our results demonstrate an antidepressive effect of Cb in CUMS mice 
      partially attributed to stimulation of intestinal GLP-1 secretion and activation 
      of cerebral GLP-1R.
FAU - Sun, Jing
AU  - Sun J
AD  - Department of Neurology , The Second Affiliated Hospital and Yuying Children's 
      Hospital of Wenzhou Medical University , Wenzhou , Zhejiang 325027 , China.
FAU - Wang, Fangyan
AU  - Wang F
AD  - Department of Emergency Medicine , The Second Affiliated Hospital and Yuying 
      Children's Hospital of Wenzhou Medical University , Wenzhou , Zhejiang 325027 , 
      China.
FAU - Hu, Xuezhen
AU  - Hu X
AD  - Department of Pathophysiology, School of Basic Medicine Science , Wenzhou Medical 
      University , Wenzhou , Zhejiang 325035 , China.
FAU - Yang, Changwei
AU  - Yang C
AD  - Department of Preventive Medicine, School of Public Health and Management , 
      Wenzhou Medical University , Wenzhou , Zhejiang 325035 , China.
FAU - Xu, Hailing
AU  - Xu H
AD  - Department of Preventive Medicine, School of Public Health and Management , 
      Wenzhou Medical University , Wenzhou , Zhejiang 325035 , China.
FAU - Yao, Ye
AU  - Yao Y
AD  - Department of Preventive Medicine, School of Public Health and Management , 
      Wenzhou Medical University , Wenzhou , Zhejiang 325035 , China.
FAU - Liu, Jiaming
AU  - Liu J
AUID- ORCID: 0000-0002-0483-3187
AD  - Department of Preventive Medicine, School of Public Health and Management , 
      Wenzhou Medical University , Wenzhou , Zhejiang 325035 , China.
LA  - eng
PT  - Journal Article
DEP - 20180724
PL  - United States
TA  - J Agric Food Chem
JT  - Journal of agricultural and food chemistry
JID - 0374755
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Glp1r protein, mouse)
RN  - 0 (Glucagon-Like Peptide-1 Receptor)
RN  - 333DO1RDJY (Serotonin)
RN  - 89750-14-1 (Glucagon-Like Peptide 1)
SB  - IM
MH  - Animals
MH  - Behavior, Animal
MH  - Brain/*physiology
MH  - Brain Chemistry
MH  - Brain-Derived Neurotrophic Factor/analysis
MH  - Clostridium butyricum/*physiology
MH  - Depression/etiology/*therapy
MH  - Disease Models, Animal
MH  - Gastrointestinal Microbiome/physiology
MH  - Glucagon-Like Peptide 1/metabolism
MH  - Glucagon-Like Peptide-1 Receptor/physiology
MH  - Intestinal Mucosa/metabolism
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Probiotics/*administration & dosage
MH  - Serotonin/analysis
MH  - Stress, Psychological
OTO - NOTNLM
OT  - BDNF
OT  - depression
OT  - glucagon-like peptide-1
OT  - gut microbiota
OT  - probiotics
EDAT- 2018/07/25 06:00
MHDA- 2018/08/21 06:00
CRDT- 2018/07/25 06:00
PHST- 2018/07/25 06:00 [pubmed]
PHST- 2018/08/21 06:00 [medline]
PHST- 2018/07/25 06:00 [entrez]
AID - 10.1021/acs.jafc.8b02462 [doi]
PST - ppublish
SO  - J Agric Food Chem. 2018 Aug 8;66(31):8415-8421. doi: 10.1021/acs.jafc.8b02462. 
      Epub 2018 Jul 24.