PMID- 30040795
OWN - NLM
STAT- MEDLINE
DCOM- 20190517
LR  - 20190517
IS  - 1997-7298 (Print)
IS  - 1997-7298 (Linking)
VI  - 118
IP  - 6
DP  - 2018
TI  - [Effects of childhood trauma on the biochemical correlates of stress in men and 
      women with nonpsychotic mental disorders].
PG  - 10-14
LID - 10.17116/jnevro20181186110 [doi]
AB  - AIM: To investigate gender differences in biochemical characteristics in patients 
      with nonpsychotic mental disorders, and to study their association with childhood 
      trauma. MATERIAL AND METHODS: Women (n=308) and men (92) between 18 and 45 years 
      of age, without serious somatic comorbidities, were examined. Laboratory 
      evaluation included markers of hypothalamic-pituitary-adrenal axis activity 
      (cortisol), hypothalamic-pituitary-thyroid system (TSH), proinflammatory 
      cytokines (Il-1beta and Il-6) and the brain derived neurotrophic factor (BDNF). All 
      participants underwent psychometric testing, which included the Child Abuse and 
      Trauma Scale (CATS), Beck and Hamilton depression scale (HAM-D) and Spielberger 
      Anxiety Inventory (STAI). Correlations were studied between the biochemical 
      parameters and total CATS scores and severity of depression and anxiety in 
      subgroups of women and men with a depressive disorder. RESULTS AND CONCLUSION: 
      The men and women in the total study population significantly differed by 
      representation of the different diagnostic classes, which was reflected by 
      differing levels of depressive and anxiety symptoms. The main finding was a 
      correlation between the level of childhood trauma and morning serum cortisol 
      levels in men with depressive disorder, which was absent in women.
FAU - Druzhkova, T A
AU  - Druzhkova TA
AD  - Moscow Research and Clinical Center for Neuropsychiatry, Healthcare Department of 
      Moscow, Moscow, Russia.
FAU - Pochigaeva, K I
AU  - Pochigaeva KI
AD  - Moscow Research and Clinical Center for Neuropsychiatry, Healthcare Department of 
      Moscow, Moscow, Russia.
FAU - Yakovlev, A A
AU  - Yakovlev AA
AD  - Moscow Research and Clinical Center for Neuropsychiatry, Healthcare Department of 
      Moscow, Moscow, Russia; Institute of Higher Nervous Activity and Neurophysiology, 
      Russian Academy of Sciences, Moscow, Russia.
FAU - Gersamia, A G
AU  - Gersamia AG
AD  - Moscow Research and Clinical Center for Neuropsychiatry, Healthcare Department of 
      Moscow, Moscow, Russia.
FAU - Guekht, A B
AU  - Guekht AB
AD  - Moscow Research and Clinical Center for Neuropsychiatry, Healthcare Department of 
      Moscow, Moscow, Russia; Pirogov Russian National Research Medical University, 
      Moscow, Russia.
FAU - Gulyaeva, N V
AU  - Gulyaeva NV
AD  - Moscow Research and Clinical Center for Neuropsychiatry, Healthcare Department of 
      Moscow, Moscow, Russia; Institute of Higher Nervous Activity and Neurophysiology, 
      Russian Academy of Sciences, Moscow, Russia.
LA  - rus
PT  - Journal Article
TT  - Vliianie travmatizatsii v detskom vozraste na biologicheskie korreliaty stressa u 
      muzhchin i zhenshchin s pogranichnymi psikhicheskimi rasstroistvami.
PL  - Russia (Federation)
TA  - Zh Nevrol Psikhiatr Im S S Korsakova
JT  - Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
JID - 9712194
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Anxiety
MH  - Child
MH  - Female
MH  - Humans
MH  - Hydrocortisone
MH  - *Hypothalamo-Hypophyseal System
MH  - Male
MH  - *Pituitary-Adrenal System
MH  - Psychiatric Status Rating Scales
MH  - *Stress, Physiological
OTO - NOTNLM
OT  - childhood trauma
OT  - cortisol
OT  - depression
OT  - stress
EDAT- 2018/07/25 06:00
MHDA- 2019/05/18 06:00
CRDT- 2018/07/25 06:00
PHST- 2018/07/25 06:00 [entrez]
PHST- 2018/07/25 06:00 [pubmed]
PHST- 2019/05/18 06:00 [medline]
AID - 10.17116/jnevro20181186110 [doi]
PST - ppublish
SO  - Zh Nevrol Psikhiatr Im S S Korsakova. 2018;118(6):10-14. doi: 
      10.17116/jnevro20181186110.