PMID- 30040921
OWN - NLM
STAT- MEDLINE
DCOM- 20190212
LR  - 20190215
IS  - 1873-3492 (Electronic)
IS  - 0009-8981 (Linking)
VI  - 486
DP  - 2018 Nov
TI  - Elevated creatinine in a patient on IVIG-therapy.
PG  - 94-97
LID - S0009-8981(18)30385-1 [pii]
LID - 10.1016/j.cca.2018.07.038 [doi]
AB  - BACKGROUND: Intravenous immunoglobulin (IVIG) is prepared from the plasma of 
      hundreds of blood donors and is used in the treatment of immunodeficiencies, 
      autoimmune conditions, infections and inflammatory conditions. IVIG formulations 
      contain one of a number of small molecule stabilizers, including sugars, polyols, 
      and amino acids, some of which can cause acute renal failure. CASE REPORT: A 61 
      y-old woman was treated for paraneoplastic syndrome due to small cell lung cancer 
      in which a creatinine measurement unexpectedly increased during IVIG therapy. 
      This increased creatinine measurement was due to the proline stabilizer in the 
      IVIG fluid that had inadvertently diluted the blood sample. Investigation 
      revealed that proline causes a positive interference in enzymatic creatinine 
      assays, likely due to the activity of sarcosine oxidase, a key component of the 
      assay, on proline. CONCLUSIONS: Increased proline concentrations can occur after 
      administration of high-dose proline (as was the case here) or in the rare 
      metabolic disorders hyperprolinema types I and II.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Knezevic, Claire E
AU  - Knezevic CE
AD  - Department of Pathology, Johns Hopkins University School of Medicine, 1800 
      Orleans Street, Baltimore, MD 21287, USA.
FAU - Ness, Mary Ann
AU  - Ness MA
AD  - Department of Pathology, Johns Hopkins University School of Medicine, 1800 
      Orleans Street, Baltimore, MD 21287, USA.
FAU - Kratz, Lisa E
AU  - Kratz LE
AD  - Department of Neurogenetics, Kennedy Krieger Institute, 707 N Broadway, 
      Baltimore, MD 21205, USA.
FAU - Marzinke, Mark A
AU  - Marzinke MA
AD  - Department of Pathology, Johns Hopkins University School of Medicine, 1800 
      Orleans Street, Baltimore, MD 21287, USA. Electronic address: mmarzin1@jhmi.edu.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20180721
PL  - Netherlands
TA  - Clin Chim Acta
JT  - Clinica chimica acta; international journal of clinical chemistry
JID - 1302422
RN  - 0 (Immunoglobulins, Intravenous)
RN  - 9DLQ4CIU6V (Proline)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Carcinoma, Non-Small-Cell Lung/blood/*therapy
MH  - Creatinine/*blood
MH  - Female
MH  - Humans
MH  - *Immunoglobulins, Intravenous
MH  - Lung Neoplasms/blood/*therapy
MH  - Middle Aged
MH  - Paraneoplastic Syndromes/blood/*therapy
MH  - Proline/blood
OTO - NOTNLM
OT  - Creatinine
OT  - Hyperprolinemia
OT  - Interference
OT  - Intravenous immunoglobulin
EDAT- 2018/07/25 06:00
MHDA- 2019/02/13 06:00
CRDT- 2018/07/25 06:00
PHST- 2018/07/06 00:00 [received]
PHST- 2018/07/20 00:00 [revised]
PHST- 2018/07/20 00:00 [accepted]
PHST- 2018/07/25 06:00 [pubmed]
PHST- 2019/02/13 06:00 [medline]
PHST- 2018/07/25 06:00 [entrez]
AID - S0009-8981(18)30385-1 [pii]
AID - 10.1016/j.cca.2018.07.038 [doi]
PST - ppublish
SO  - Clin Chim Acta. 2018 Nov;486:94-97. doi: 10.1016/j.cca.2018.07.038. Epub 2018 Jul 
      21.