PMID- 30042059
OWN - NLM
STAT- MEDLINE
DCOM- 20190930
LR  - 20221207
IS  - 1873-460X (Electronic)
IS  - 1056-8727 (Linking)
VI  - 32
IP  - 10
DP  - 2018 Oct
TI  - Clinical implication of alterations in serum Klotho levels in patients with type 
      2 diabetes mellitus and its associated complications.
PG  - 922-930
LID - S1056-8727(18)30263-0 [pii]
LID - 10.1016/j.jdiacomp.2018.06.002 [doi]
AB  - AIM: To investigate the clinical significance of serum alpha-Klotho and beta-Klotho 
      levels in patients with type 2 diabetes mellitus (T2DM) and its associated 
      complications. METHODS: Serum alpha-Klotho and beta-Klotho levels were measured using an 
      ELISA kit in 817 individuals, including 127 with T2DM, 106 with diabetic 
      nephropathy, 99 with diabetic retinopathy, 108 with diabetic neuropathy, 102 with 
      diabetic foot disease, 135 with T2DM and more than one complication and 140 
      healthy controls. RESULTS: Both alpha-Klotho and beta-Klotho levels were significantly 
      decreased in the T2DM group and the groups with associated complications compared 
      with the levels in control group. The differences between the T2DM group and the 
      T2DM with complications groups were not significant, except between the diabetic 
      nephropathy group and the other diabetic complications groups. In addition, 
      alpha-Klotho and beta-Klotho levels were negatively correlated with serum fructosamine 
      and HbA1c but were not associated with serum glucose in the model including all 
      participants. Moreover, decreases in alpha-Klotho and beta-Klotho levels in the high 
      glucose-exposed cell culture model, which was dependent on glucose exposure time, 
      were confirmed. CONCLUSIONS: Levels of alpha-Klotho and beta-Klotho were downregulated 
      in patients in the T2DM and complications groups. Our findings indicate that 
      serum Klotho levels were associated with the development of T2DM, and long-term 
      control of blood glucose will be beneficial in ameliorating changes to alpha-Klotho 
      and beta-Klotho levels in patients with T2DM and complications.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Zhang, Lingling
AU  - Zhang L
AD  - Department of Laboratory, The First Affiliated Hospital of Shantou University 
      Medical College, Shantou, Guangdong 515041, PR China.
FAU - Liu, Tianming
AU  - Liu T
AD  - Department of Laboratory, The First Affiliated Hospital of Shantou University 
      Medical College, Shantou, Guangdong 515041, PR China. Electronic address: 
      tian198504@126.com.
LA  - eng
PT  - Journal Article
DEP - 20180612
PL  - United States
TA  - J Diabetes Complications
JT  - Journal of diabetes and its complications
JID - 9204583
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (KLB protein, human)
RN  - 0 (Membrane Proteins)
RN  - 4429-04-3 (Fructosamine)
RN  - EC 3.2.1.31 (Glucuronidase)
RN  - EC 3.2.1.31 (Klotho Proteins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers/blood
MH  - Blood Glucose/analysis
MH  - Case-Control Studies
MH  - Diabetes Complications/*blood
MH  - Diabetes Mellitus, Type 2/*blood/*complications
MH  - Female
MH  - Fructosamine/blood
MH  - Glucuronidase/*blood
MH  - Glycated Hemoglobin/analysis
MH  - Humans
MH  - Klotho Proteins
MH  - Male
MH  - Membrane Proteins/*blood
MH  - Middle Aged
MH  - Severity of Illness Index
OTO - NOTNLM
OT  - Fructosamine
OT  - Glucose
OT  - HbA1c
OT  - Klotho
OT  - Type 2 diabetes mellitus
EDAT- 2018/07/26 06:00
MHDA- 2019/10/01 06:00
CRDT- 2018/07/26 06:00
PHST- 2018/03/11 00:00 [received]
PHST- 2018/06/05 00:00 [revised]
PHST- 2018/06/06 00:00 [accepted]
PHST- 2018/07/26 06:00 [pubmed]
PHST- 2019/10/01 06:00 [medline]
PHST- 2018/07/26 06:00 [entrez]
AID - S1056-8727(18)30263-0 [pii]
AID - 10.1016/j.jdiacomp.2018.06.002 [doi]
PST - ppublish
SO  - J Diabetes Complications. 2018 Oct;32(10):922-930. doi: 
      10.1016/j.jdiacomp.2018.06.002. Epub 2018 Jun 12.