PMID- 30043211
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230522
IS  - 1869-6953 (Print)
IS  - 1869-6961 (Electronic)
IS  - 1869-6961 (Linking)
VI  - 9
IP  - 5
DP  - 2018 Oct
TI  - Association Trends Between Antihypertensive Drug Therapies and Diastolic 
      Hypotension in Emirati Patients with Type 2 Diabetes: A Single-Center 
      Retrospective Longitudinal Study.
PG  - 1853-1868
LID - 10.1007/s13300-018-0469-2 [doi]
AB  - INTRODUCTION: Diabetes mellitus (DM) is associated with multiple complications, 
      including cardiovascular diseases. Previously, it was believed that the latter 
      are mainly caused by hypertension and increased systolic blood pressure. However, 
      recent studies have challenged this concept, by showing that diastolic 
      dysfunction may also be involved in the cardiovascular events that are associated 
      with DM. Pharmacologic management of hypertension in patients with type 2 DM 
      appears to adversely influence diastolic function. METHODS: Four hundred and 
      eight medical records of hypertensive and obese Emirati patients with type 2 DM 
      were included in the present retrospective study. The main objectives of the 
      present study were (1) to determine the prevalence of low diastolic blood 
      pressure (DBP) and diastolic hypotension in this group of patients and (2) to 
      investigate the associations, if any, between the use of various antihypertensive 
      medications and low DBP and diastolic hypotension. RESULTS: The results of the 
      present study showed that low DBP (< 70 mmHg) was experienced by 40% of the 
      hypertensive type 2 DM patients, whereas diastolic hypotension (< 60 mmHg) was 
      reported to occur in about 10% of the patients. Another important factor that has 
      been significantly correlated with diastolic hypotension is age (p < 0.01). 
      Association trends have been reported between low DBP and diastolic hypotension 
      and several antihypertensive therapies, including (1) monotherapies such as 
      angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor 
      blockers (ARBs), (2) dual therapies such as ACE inhibitors in combination with 
      thiazide-like diuretics (THLDs) or beta blockers, and (3) triple therapy 
      combinations of ACE inhibitors with THLDs and potassium-sparing diuretics. 
      CONCLUSION: The use of antihypertensive medications, in particular ACE inhibitors 
      and ARBs, appears to be a risk factor for the development of low DBP and 
      diastolic hypotension in obese hypertensive Emirati patients with type 2 DM, 
      whereas calcium channel blockers seem to be a safer option for this group of 
      patients.
FAU - Mussa, Bashair M
AU  - Mussa BM
AD  - Basic Medical Science Department, College of Medicine, University of Sharjah, 
      Sharjah, United Arab Emirates. bmussa@sharjah.ac.ae.
FAU - Hamoudi, Rifat A
AU  - Hamoudi RA
AD  - Clinical Science Department, College of Medicine, University of Sharjah, Sharjah, 
      United Arab Emirates.
FAU - Abusnana, Salah E
AU  - Abusnana SE
AD  - Clinical Science Department, College of Medicine, University Hospital Sharjah, 
      Sharjah, United Arab Emirates.
LA  - eng
PT  - Journal Article
DEP - 20180724
PL  - United States
TA  - Diabetes Ther
JT  - Diabetes therapy : research, treatment and education of diabetes and related 
      disorders
JID - 101539025
PMC - PMC6167282
OTO - NOTNLM
OT  - Angiotensin II receptor blocker
OT  - Angiotensin-converting enzyme inhibitors
OT  - Antihypertensive medications
OT  - Calcium channel blockers
OT  - Diastolic blood pressure
OT  - Diastolic hypotension
OT  - Systolic blood pressure
OT  - Type 2 diabetes
EDAT- 2018/07/26 06:00
MHDA- 2018/07/26 06:01
PMCR- 2018/07/24
CRDT- 2018/07/26 06:00
PHST- 2018/05/18 00:00 [received]
PHST- 2018/07/26 06:00 [pubmed]
PHST- 2018/07/26 06:01 [medline]
PHST- 2018/07/26 06:00 [entrez]
PHST- 2018/07/24 00:00 [pmc-release]
AID - 10.1007/s13300-018-0469-2 [pii]
AID - 469 [pii]
AID - 10.1007/s13300-018-0469-2 [doi]
PST - ppublish
SO  - Diabetes Ther. 2018 Oct;9(5):1853-1868. doi: 10.1007/s13300-018-0469-2. Epub 2018 
      Jul 24.