PMID- 30043858
OWN - NLM
STAT- MEDLINE
DCOM- 20180906
LR  - 20201209
IS  - 1414-431X (Electronic)
IS  - 0100-879X (Print)
IS  - 0100-879X (Linking)
VI  - 51
IP  - 9
DP  - 2018 Jul 23
TI  - Decreased expression of chromodomain helicase DNA-binding protein 9 is a novel 
      independent prognostic biomarker for colorectal cancer.
PG  - e7588
LID - S0100-879X2018000900612 [pii]
LID - 10.1590/1414-431X20187588 [doi]
LID - e7588
AB  - Previous studies suggested that chromodomain helicase DNA-binding proteins 
      (CHDs), including CHD 1-8, were associated with several human diseases and 
      cancers including lymphoma, liver cancer, colorectal cancer, stomach cancer, etc. 
      To date, little research on CHD 9 in human cancers has been reported. In this 
      study, we assessed the prognostic value of CHD 9 in patients with colorectal 
      cancer (CRC). We screened for CHD 9 expression using immunohistochemical analysis 
      in 87 surgical CRC specimens and found that the expression was upregulated in 
      81.5% of the cases, while 7.4% were decreased; in the remaining 11.1% of the 
      cases, levels were not altered. Kaplan-Meier analysis showed that patients with 
      high CHD 9 expression had better prognosis than those with low CHD 9 expression 
      (54.5 vs 32.1%, P=0.034). Subsequently, Cox multi-factor survival regression 
      analysis revealed that expression of CHD 9 protein was an independent predictor 
      for CRC, with a hazard ratio of 0.503 (P=0.028). In addition, we found that CHD 9 
      expression was positively correlated with MSH2 (rs=0.232, P=0.036). We speculated 
      that CHD9 might be a putative tumor suppressor gene, and could inhibit the 
      development of CRC by participating in DNA repair processes. Our findings suggest 
      that CHD 9 could be a novel prognostic biomarker and a therapeutic target for 
      CRC. Further studies are needed to detect the effect of CHD 9 on cellular 
      function and the expression of mismatch repair genes.
FAU - Xu, Li
AU  - Xu L
AD  - Department of General Surgery, the First Affiliated Yijishan Hospital of Wannan 
      Medical College, Wuhu, Anhui, China.
FAU - Peng, Hui
AU  - Peng H
AD  - Administration Office of Hospital Admission and Discharge, the First Affiliated 
      Yijishan Hospital of Wannan Medical College, Wuhu, Anhui, China.
FAU - Huang, Xiao-Xu
AU  - Huang XX
AD  - Department of General Surgery, the First Affiliated Yijishan Hospital of Wannan 
      Medical College, Wuhu, Anhui, China.
FAU - Xia, Ya-Bin
AU  - Xia YB
AD  - Department of General Surgery, the First Affiliated Yijishan Hospital of Wannan 
      Medical College, Wuhu, Anhui, China.
FAU - Hu, Kai-Feng
AU  - Hu KF
AD  - Department of General Surgery, the First Affiliated Yijishan Hospital of Wannan 
      Medical College, Wuhu, Anhui, China.
FAU - Zhang, Zheng-Ming
AU  - Zhang ZM
AD  - Department of General Surgery, the First Affiliated Yijishan Hospital of Wannan 
      Medical College, Wuhu, Anhui, China.
LA  - eng
PT  - Journal Article
DEP - 20180723
PL  - Brazil
TA  - Braz J Med Biol Res
JT  - Brazilian journal of medical and biological research = Revista brasileira de 
      pesquisas medicas e biologicas
JID - 8112917
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Trans-Activators)
RN  - 0 (Transcription Factors)
RN  - EC 3.6.4.- (DNA Helicases)
RN  - EC 3.6.4.12 (CHD9 protein, human)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers, Tumor/genetics/*metabolism
MH  - Colorectal Neoplasms/genetics/*metabolism/pathology
MH  - DNA Helicases
MH  - DNA-Binding Proteins/genetics/*metabolism
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Immunohistochemistry
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Trans-Activators
MH  - Transcription Factors/genetics/*metabolism
MH  - Young Adult
PMC - PMC6065814
EDAT- 2018/07/26 06:00
MHDA- 2018/09/07 06:00
PMCR- 2018/07/23
CRDT- 2018/07/26 06:00
PHST- 2018/03/15 00:00 [received]
PHST- 2018/05/15 00:00 [accepted]
PHST- 2018/07/26 06:00 [entrez]
PHST- 2018/07/26 06:00 [pubmed]
PHST- 2018/09/07 06:00 [medline]
PHST- 2018/07/23 00:00 [pmc-release]
AID - S0100-879X2018000900612 [pii]
AID - 10.1590/1414-431X20187588 [doi]
PST - epublish
SO  - Braz J Med Biol Res. 2018 Jul 23;51(9):e7588. doi: 10.1590/1414-431X20187588.