PMID- 30045820
OWN - NLM
STAT- MEDLINE
DCOM- 20190311
LR  - 20190311
IS  - 1874-1754 (Electronic)
IS  - 0167-5273 (Linking)
VI  - 271
DP  - 2018 Nov 15
TI  - Role of right ventricular involvement in acute myocarditis, assessed by cardiac 
      magnetic resonance.
PG  - 359-365
LID - S0167-5273(17)37691-X [pii]
LID - 10.1016/j.ijcard.2018.04.087 [doi]
AB  - OBJECTIVES: Right ventricular (RV) myocarditis (MY) is unrecognized, and its 
      prevalence is unknown. We evaluated the prevalence of RV involvement in acute MY 
      and its association with cardiac events (cardiac death, cardiac arrest, 
      ventricular assist device, transplantation, and appropriate ICD intervention). 
      METHODS: We enrolled 151 patients who underwent cardiac magnetic resonance for 
      clinical suspicion of acute MY. The CMR protocol included T2-STIR images for 
      edema detection, post-contrast cine-SSFP for hyperemia detection and late 
      gadolinium enhancement (LGE) images. RESULTS: Signs of RV MY were found in 27 
      patients (17.8%): RV edema at T2-STIR in all of these 27 patients; RV LGE was 
      detected in 11 patients (7.3%). The median RV myocardial segment involved was 2 
      (1-3). In 13 patients, RV edema was in direct continuity with LV edema of septum 
      and inferior wall or with anterior septum and anterior wall. In 2 patients RV 
      myocarditis was found without any signs of LV involvement. Patients with RV MY 
      had higher RV end-diastolic volume index (p = 0.04) and RV mass index (p = 0.03), 
      and lower RV ejection fraction (p < 0.001) than others. At Kaplan-Meier survival 
      curve patients with RV MY had more cardiac events than those without RV 
      involvement (p = 0.015). RV involvement, anteroseptal LGE and RV LGE were 
      associated with cardiac events. CONCLUSION: RV involvement in acute MY is more 
      frequent than previously hypothesized. RV MY was associated with cardiac events.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Aquaro, Giovanni Donato
AU  - Aquaro GD
AD  - Fondazione Toscana G.Monasterio, Pisa, Italy. Electronic address: aquaro@ftgm.it.
FAU - Negri, Francesco
AU  - Negri F
AD  - Cardiovascular Department "Ospedali Riuniti" of Trieste and Post Graduated School 
      of Cardiovascular Sciences, University of Trieste, Trieste, Italy.
FAU - De Luca, Antonio
AU  - De Luca A
AD  - Cardiovascular Department "Ospedali Riuniti" of Trieste and Post Graduated School 
      of Cardiovascular Sciences, University of Trieste, Trieste, Italy.
FAU - Todiere, Giancarlo
AU  - Todiere G
AD  - Fondazione Toscana G.Monasterio, Pisa, Italy.
FAU - Bianco, Francesco
AU  - Bianco F
AD  - University of Chieti, Chieti, Italy.
FAU - Barison, Andrea
AU  - Barison A
AD  - Fondazione Toscana G.Monasterio, Pisa, Italy.
FAU - Camastra, Giovanni
AU  - Camastra G
AD  - Cardiac Department, Vannini Hospital Rome, Roma, Italy.
FAU - Monti, Lorenzo
AU  - Monti L
AD  - Radiology Department, Humanitas Research Hospital, I.R.C.C.S, Rozzano, (Milan), 
      Italy.
FAU - Dellegrottaglie, Santo
AU  - Dellegrottaglie S
AD  - Division of Cardiology, Villa dei Fiori, Acerra, Napoli, Italy; Mount Sinai 
      School of Medicine, New York, USA.
FAU - Moro, Claudio
AU  - Moro C
AD  - U.O. Cardiologia e UTIC, ASST Monza, P.O. Desio, Italy.
FAU - Lanzillo, Chiara
AU  - Lanzillo C
AD  - Cardiology Department, Policlinico Casilino, Rome, Italy.
FAU - Scatteia, Alessandra
AU  - Scatteia A
AD  - Department of Advanced Biomedical Sciences, Federico II University, Naples, 
      Italy.
FAU - Di Roma, Mauro
AU  - Di Roma M
AD  - Radiological Department, European Hospital, Roma, Italy.
FAU - Pontone, Gianluca
AU  - Pontone G
AD  - Cardiac Department, Centro Cardiologico Monzino, Milano, Italy.
FAU - Perazzolo Marra, Martina
AU  - Perazzolo Marra M
AD  - Division of Cardiology, Department of Cardiac, Thoracic, and Vascular Sciences, 
      University of Padua, Padua, Italy.
FAU - Di Bella, Gianluca
AU  - Di Bella G
AD  - Clinical and Experimental Department of Medicine, University of Messina, Messina, 
      Italy.
FAU - Donato, Rocco
AU  - Donato R
AD  - Clinical and Experimental Department of Medicine, University of Messina, Messina, 
      Italy.
FAU - Grigoratos, Chrysanthos
AU  - Grigoratos C
AD  - Scuola Superiore di Perfezionamento Sant'Anna, Pisa, Italy.
FAU - Emdin, Michele
AU  - Emdin M
AD  - Fondazione Toscana G.Monasterio, Pisa, Italy; Scuola Superiore di Perfezionamento 
      Sant'Anna, Pisa, Italy.
FAU - Sinagra, Gianfranco
AU  - Sinagra G
AD  - Cardiovascular Department "Ospedali Riuniti" of Trieste and Post Graduated School 
      of Cardiovascular Sciences, University of Trieste, Trieste, Italy.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20180722
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Italy/epidemiology
MH  - Magnetic Resonance Imaging, Cine/*methods
MH  - Male
MH  - Middle Aged
MH  - Myocarditis/*diagnostic imaging/epidemiology/*physiopathology
MH  - Ventricular Function, Right/*physiology
OTO - NOTNLM
OT  - Acute myocarditis
OT  - Cardiac magnetic resonance
OT  - Late gadolinium enhancement
OT  - Myocardial edema
OT  - Prognosis
OT  - Right ventricular myocarditis
EDAT- 2018/07/27 06:00
MHDA- 2019/03/12 06:00
CRDT- 2018/07/27 06:00
PHST- 2017/12/11 00:00 [received]
PHST- 2018/04/04 00:00 [revised]
PHST- 2018/04/18 00:00 [accepted]
PHST- 2018/07/27 06:00 [pubmed]
PHST- 2019/03/12 06:00 [medline]
PHST- 2018/07/27 06:00 [entrez]
AID - S0167-5273(17)37691-X [pii]
AID - 10.1016/j.ijcard.2018.04.087 [doi]
PST - ppublish
SO  - Int J Cardiol. 2018 Nov 15;271:359-365. doi: 10.1016/j.ijcard.2018.04.087. Epub 
      2018 Jul 22.