PMID- 30046536
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2222-3959 (Print)
IS  - 2227-4898 (Electronic)
IS  - 2222-3959 (Linking)
VI  - 11
IP  - 7
DP  - 2018
TI  - Changes in choroidal thickness in healthy pediatric individuals: a longitudinal 
      study.
PG  - 1179-1184
LID - 10.18240/ijo.2018.07.17 [doi]
AB  - AIM: To investigate the changes in the choroidal thickness in healthy pediatric 
      children in a longitudinal study, and to determine the ocular and systemic 
      parameters that were significantly correlated with the changes in the choroidal 
      thickness. METHODS: This study included 64 eyes of 34 healthy Japanese children 
      with a mean age (+/-SD) of 4.4 (+/-0.4)y (range, 3.6-5.8y) at baseline. Swept-source 
      optical coherence tomography (SS-OCT) was used to record images of the retina and 
      choroid at the baseline and after a mean follow-up period of about 1.5y. The 3D 
      raster scan protocol was used to construct the choroidal thickness map. Mean 
      choroidal thickness was calculated for each of the nine sectors of the Early 
      Treatment Diabetic Retinopathy Study grid. Best-corrected visual acuity, axial 
      length, body height, and weight were also measured. Changes in measurements were 
      defined as the baseline values subtracted from the values at the final visit. A 
      generalized estimating equation was used to eliminate the effect of 
      within-subject intereye correlations. RESULTS: The mean central choroidal 
      thickness was significantly reduced during the follow-up period (baseline, 
      301.8+/-8.6 microm; final visit, 286.6+/-8.0 microm, P<0.001). The decrease in the choroidal 
      thickness was greatest in the central sector, followed by the sectors of the 
      inner and outer rings. The inner and outer rings had diameters of 1 to 3 mm and 3 
      to 6 mm, respectively. The changes in the choroidal thickness in the central, 
      inner ring, and outer ring sectors were significantly and negatively correlated 
      with the age, baseline body height, baseline body weight, and elongation of the 
      axial length. CONCLUSION: These results indicate that the choroidal thickness 
      among preschool-aged Japanese children decreased significantly during the 
      follow-up period. The choroidal thinning is significantly associated with the 
      elongation of axial length. These characteristics should be considered in the 
      evaluation of choroidal thickness in younger children with retinochoroidal 
      disorders.
FAU - Ohsugi, Eiko
AU  - Ohsugi E
AD  - Department of Ophthalmology, Saneikai Tsukazaki Hospital, Himeji 671-1227, Japan.
AD  - Department of Ophthalmology, Institute of Biomedical Sciences, Tokushima 
      University Graduate School, Tokushima 770-8503, Japan.
FAU - Mitamura, Yoshinori
AU  - Mitamura Y
AD  - Department of Ophthalmology, Institute of Biomedical Sciences, Tokushima 
      University Graduate School, Tokushima 770-8503, Japan.
FAU - Shinomiya, Kayo
AU  - Shinomiya K
AD  - Department of Ophthalmology, Institute of Biomedical Sciences, Tokushima 
      University Graduate School, Tokushima 770-8503, Japan.
FAU - Niki, Masanori
AU  - Niki M
AD  - Department of Ophthalmology, Institute of Biomedical Sciences, Tokushima 
      University Graduate School, Tokushima 770-8503, Japan.
FAU - Sano, Hiroki
AU  - Sano H
AD  - Department of Ophthalmology, Institute of Biomedical Sciences, Tokushima 
      University Graduate School, Tokushima 770-8503, Japan.
FAU - Nagasawa, Toshihiko
AU  - Nagasawa T
AD  - Department of Ophthalmology, Saneikai Tsukazaki Hospital, Himeji 671-1227, Japan.
AD  - Department of Ophthalmology, Institute of Biomedical Sciences, Tokushima 
      University Graduate School, Tokushima 770-8503, Japan.
FAU - Shimizu, Yukiko
AU  - Shimizu Y
AD  - Department of Ophthalmology, Saneikai Tsukazaki Hospital, Himeji 671-1227, Japan.
FAU - Nagasato, Daisuke
AU  - Nagasato D
AD  - Department of Ophthalmology, Saneikai Tsukazaki Hospital, Himeji 671-1227, Japan.
AD  - Department of Ophthalmology, Institute of Biomedical Sciences, Tokushima 
      University Graduate School, Tokushima 770-8503, Japan.
FAU - Tabuchi, Hitoshi
AU  - Tabuchi H
AD  - Department of Ophthalmology, Saneikai Tsukazaki Hospital, Himeji 671-1227, Japan.
AD  - Department of Ophthalmology, Institute of Biomedical Sciences, Tokushima 
      University Graduate School, Tokushima 770-8503, Japan.
LA  - eng
PT  - Journal Article
DEP - 20180718
PL  - China
TA  - Int J Ophthalmol
JT  - International journal of ophthalmology
JID - 101553860
PMC - PMC6048345
OTO - NOTNLM
OT  - choroidal thickness
OT  - longitudinal study
OT  - pediatrics
OT  - swept-source optical coherence tomography
EDAT- 2018/07/27 06:00
MHDA- 2018/07/27 06:01
PMCR- 2018/07/18
CRDT- 2018/07/27 06:00
PHST- 2017/10/26 00:00 [received]
PHST- 2018/02/05 00:00 [accepted]
PHST- 2018/07/27 06:00 [entrez]
PHST- 2018/07/27 06:00 [pubmed]
PHST- 2018/07/27 06:01 [medline]
PHST- 2018/07/18 00:00 [pmc-release]
AID - ijo-11-07-1179 [pii]
AID - 10.18240/ijo.2018.07.17 [doi]
PST - epublish
SO  - Int J Ophthalmol. 2018 Jul 18;11(7):1179-1184. doi: 10.18240/ijo.2018.07.17. 
      eCollection 2018.