PMID- 30046601
OWN - NLM
STAT- MEDLINE
DCOM- 20190114
LR  - 20220408
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2018
DP  - 2018
TI  - Antidepressant-Like Effects of Gyejibokryeong-hwan in a Mouse Model of 
      Reserpine-Induced Depression.
PG  - 5845491
LID - 10.1155/2018/5845491 [doi]
LID - 5845491
AB  - Treatment with the antihypertensive agent reserpine depletes monoamine levels, 
      resulting in depression. In the present study, we evaluated the antidepressant 
      effects of Gyejibokryeong-hwan (GBH), a traditional Korean medicine, in a mouse 
      model of reserpine-induced depression. Mice were treated with reserpine (0.5 
      mg.kg(-1), i.p.) or phosphate-buffered saline (PBS, i.p., normal) once daily for 
      10 days. GBH (50, 100, 300, and 500 mg.kg(-1)), PBS (normal, control), fluoxetine 
      (FXT, 20 mg.kg(-1)), or amitriptyline (AMT, 30 mg.kg(-1)) was administered orally 
      1 h prior to reserpine treatment. Mouse behavior was examined in the forced swim 
      test (FST), tail suspension test (TST), and open-field test (OFT) following 
      completion of the treatment protocol. Administration of GBH reduced immobility 
      time in the FST and TST and significantly increased the total distance traveled 
      in the OFT. Plasma serotonin levels were significantly lower in control mice than 
      in normal mice, although these decreases were significantly attenuated to a 
      similar extent by treatment with GBH, FXT, or AMT. Reserpine-induced increases in 
      plasma corticosterone were also attenuated by GBH treatment. Moreover, GBH 
      attenuated reserpine-induced increases in interleukin- (IL-) 1beta, IL-6, and tumor 
      necrosis factor- (TNF-) alpha mRNA expression in the hippocampus. In addition, GBH 
      mice exhibited increased levels of brain-derived neurotrophic factor (BDNF) and a 
      higher ratio of phosphorylated cAMP response element-binding protein (p-CREB) to 
      CREB (p-CREB/CREB) in the hippocampus. Our results indicated that GBH can 
      ameliorate depressive-like behaviors, affect the concentration of mood-related 
      hormones, and help to regulate immune/endocrine dysfunction in mice with 
      reserpine-induced depression, likely via activation of the BDNF-CREB pathway. 
      Taken together, these findings indicate that GBH may be effective in treating 
      patients with depression.
FAU - Park, Bo-Kyung
AU  - Park BK
AD  - Clinical Medicine Division, Korea Institute of Oriental Medicine, Daejeon 34054, 
      Republic of Korea.
FAU - Kim, Yu Ri
AU  - Kim YR
AD  - Clinical Medicine Division, Korea Institute of Oriental Medicine, Daejeon 34054, 
      Republic of Korea.
FAU - Kim, Young Hwa
AU  - Kim YH
AD  - Clinical Medicine Division, Korea Institute of Oriental Medicine, Daejeon 34054, 
      Republic of Korea.
FAU - Yang, Changsop
AU  - Yang C
AUID- ORCID: 0000-0003-1277-3329
AD  - Clinical Medicine Division, Korea Institute of Oriental Medicine, Daejeon 34054, 
      Republic of Korea.
FAU - Seo, Chang-Seob
AU  - Seo CS
AUID- ORCID: 0000-0002-8156-446X
AD  - Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon 
      34054, Republic of Korea.
FAU - Jung, In Chul
AU  - Jung IC
AD  - Department of Oriental Neuropsychiatry, College of Korean Medicine, Daejeon 
      University, Daejeon 34520, Republic of Korea.
FAU - Jang, Ik-Soon
AU  - Jang IS
AD  - Division of Bioconvergence Analysis, Korea Basic Science Institute, Daejeon 
      34133, Republic of Korea.
FAU - Kim, Seung-Hyung
AU  - Kim SH
AD  - Institute of Traditional Medicine and Bioscience, Daejeon University, Daejeon 
      34520, Republic of Korea.
FAU - Lee, Mi Young
AU  - Lee MY
AUID- ORCID: 0000-0002-3308-340X
AD  - Clinical Medicine Division, Korea Institute of Oriental Medicine, Daejeon 34054, 
      Republic of Korea.
LA  - eng
PT  - Journal Article
DEP - 20180626
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 8B1QWR724A (Reserpine)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/*therapeutic use
MH  - Brain-Derived Neurotrophic Factor
MH  - Depression/*drug therapy
MH  - Depressive Disorder
MH  - Humans
MH  - *Medicine, East Asian Traditional
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Reserpine
PMC - PMC6038693
EDAT- 2018/07/27 06:00
MHDA- 2019/01/15 06:00
PMCR- 2018/06/26
CRDT- 2018/07/27 06:00
PHST- 2018/02/21 00:00 [received]
PHST- 2018/05/11 00:00 [revised]
PHST- 2018/05/28 00:00 [accepted]
PHST- 2018/07/27 06:00 [entrez]
PHST- 2018/07/27 06:00 [pubmed]
PHST- 2019/01/15 06:00 [medline]
PHST- 2018/06/26 00:00 [pmc-release]
AID - 10.1155/2018/5845491 [doi]
PST - epublish
SO  - Biomed Res Int. 2018 Jun 26;2018:5845491. doi: 10.1155/2018/5845491. eCollection 
      2018.