PMID- 30046926
OWN - NLM
STAT- MEDLINE
DCOM- 20190509
LR  - 20191210
IS  - 1573-6792 (Electronic)
IS  - 0896-0267 (Linking)
VI  - 32
IP  - 1
DP  - 2019 Jan
TI  - Extraversion and Neuroticism Related to Topological Efficiency in White Matter 
      Network: An Exploratory Study Using Diffusion Tensor Imaging Tractography.
PG  - 87-96
LID - 10.1007/s10548-018-0665-4 [doi]
AB  - White matter (WM) fibers underpin individual differences in extraversion and 
      neuroticism. These personality traits are associated with integration of emotion, 
      cognition, and behavior, which rely on a large-scale brain network. Thus, 
      research at network level is needed to characterize neural underpinnings of 
      extraversion and neuroticism. We performed diffusion tensor imaging on 68 healthy 
      individuals and combined a WM network with graph theory analysis to investigate 
      the connectivity of the whole-brain network and individual regions associated 
      with extraversion and neuroticism. Extraversion was negatively associated with 
      local efficiency in the medial prefrontal cortex (MPFC), and neuroticism was 
      positively associated with local and global efficiencies mainly in the 
      hippocampus and MPFC regions, respectively. These identified regions demonstrated 
      connectivity with other cortical and subcortical regions. No reliable 
      associations were found between the network local and global efficiencies and 
      extraversion, as well as neuroticism. These findings indicated the association 
      between specific personality dimensions and information transfer in the 
      prefrontal-limbic regions, which provided further insight into the neural 
      mechanism to characterize extraversion and neuroticism.
FAU - Pang, Yajing
AU  - Pang Y
AD  - The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for 
      Neuroinformation, University of Electronic Science and Technology of China, 
      Chengdu, China.
AD  - School of Life Science and Technology, Center for Information in Medicine, 
      University of Electronic Science and Technology of China, Chengdu, China.
FAU - Chen, Heng
AU  - Chen H
AD  - The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for 
      Neuroinformation, University of Electronic Science and Technology of China, 
      Chengdu, China.
AD  - School of Life Science and Technology, Center for Information in Medicine, 
      University of Electronic Science and Technology of China, Chengdu, China.
FAU - Chen, Yuyan
AU  - Chen Y
AD  - The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for 
      Neuroinformation, University of Electronic Science and Technology of China, 
      Chengdu, China.
AD  - School of Life Science and Technology, Center for Information in Medicine, 
      University of Electronic Science and Technology of China, Chengdu, China.
FAU - Cui, Qian
AU  - Cui Q
AD  - School of Public Administration, University of Electronic Science and Technology 
      of China, Chengdu, China. qiancui26@gmail.com.
FAU - Wang, Yifeng
AU  - Wang Y
AD  - The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for 
      Neuroinformation, University of Electronic Science and Technology of China, 
      Chengdu, China.
AD  - School of Life Science and Technology, Center for Information in Medicine, 
      University of Electronic Science and Technology of China, Chengdu, China.
FAU - Zhang, Zhiqiang
AU  - Zhang Z
AD  - Department of Medical Imaging, Jinling Hospital, Nanjing University School of 
      Medicine, Nanjing, China.
FAU - Lu, Guangming
AU  - Lu G
AD  - Department of Medical Imaging, Jinling Hospital, Nanjing University School of 
      Medicine, Nanjing, China.
FAU - Chen, Huafu
AU  - Chen H
AUID- ORCID: 0000-0002-4062-4753
AD  - The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for 
      Neuroinformation, University of Electronic Science and Technology of China, 
      Chengdu, China. chenhf@uestc.edu.cn.
AD  - School of Life Science and Technology, Center for Information in Medicine, 
      University of Electronic Science and Technology of China, Chengdu, China. 
      chenhf@uestc.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180725
PL  - United States
TA  - Brain Topogr
JT  - Brain topography
JID - 8903034
SB  - IM
MH  - Brain Mapping
MH  - *Diffusion Tensor Imaging
MH  - *Extraversion, Psychological
MH  - Humans
MH  - *Neuroticism
MH  - Personality Assessment
MH  - Prefrontal Cortex/*diagnostic imaging
MH  - White Matter/*diagnostic imaging
OTO - NOTNLM
OT  - Extraversion
OT  - Graph theory analysis
OT  - Neuroticism
OT  - White matter network
EDAT- 2018/07/27 06:00
MHDA- 2019/05/10 06:00
CRDT- 2018/07/27 06:00
PHST- 2017/12/23 00:00 [received]
PHST- 2018/07/17 00:00 [accepted]
PHST- 2018/07/27 06:00 [pubmed]
PHST- 2019/05/10 06:00 [medline]
PHST- 2018/07/27 06:00 [entrez]
AID - 10.1007/s10548-018-0665-4 [pii]
AID - 10.1007/s10548-018-0665-4 [doi]
PST - ppublish
SO  - Brain Topogr. 2019 Jan;32(1):87-96. doi: 10.1007/s10548-018-0665-4. Epub 2018 Jul 
      25.