PMID- 30047340
OWN - NLM
STAT- MEDLINE
DCOM- 20191011
LR  - 20220408
IS  - 1996-3181 (Electronic)
IS  - 1871-5273 (Linking)
VI  - 17
IP  - 8
DP  - 2018
TI  - Metabolic Syndrome and Its Effect on the Brain: Possible Mechanism.
PG  - 595-603
LID - 10.2174/1871527317666180724143258 [doi]
AB  - BACKGROUND & OBJECTIVE: Metabolic syndrome (MetS) is an interconnected group of 
      physiological, biochemical, clinical and metabolic factors that directly increase 
      the risk of cardiovascular disease, type 2 diabetes mellitus (T2DM) and 
      mortality. Rising evidence suggests that MetS plays a significant role in the 
      progression of Alzheimer's disease and other neurodegenerative diseases. 
      Nonetheless, the factors linking this association has not yet been elucidated. As 
      we are facing an increasing incidence of obesity and T2DM in all stages of life, 
      understanding the association of MetS and neurodegenerative diseases is crucial 
      to lessen the burden of the disease. CONCLUSION: In this review, we will discuss 
      the possible mechanisms which may relate the association between MetS and 
      cognitive decline which include vascular damages, elevation of reactive oxygen 
      species (ROS), insulin resistance and low-grade inflammation.
CI  - Copyright(c) Bentham Science Publishers; For any queries, please email at 
      epub@benthamscience.org.
FAU - Arshad, Nurul 'Ain
AU  - Arshad N'
AD  - Department of Anatomy, Universiti Kebangsaan Malaysia Medical Centre, 56000 Kuala 
      Lumpur, Malaysia.
FAU - Lin, Teoh Seong
AU  - Lin TS
AD  - Department of Anatomy, Universiti Kebangsaan Malaysia Medical Centre, 56000 Kuala 
      Lumpur, Malaysia.
FAU - Yahaya, Mohamad Fairuz
AU  - Yahaya MF
AD  - Department of Anatomy, Universiti Kebangsaan Malaysia Medical Centre, 56000 Kuala 
      Lumpur, Malaysia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United Arab Emirates
TA  - CNS Neurol Disord Drug Targets
JT  - CNS & neurological disorders drug targets
JID - 101269155
RN  - 0 (Reactive Oxygen Species)
SB  - IM
MH  - Brain/*metabolism/*physiopathology
MH  - Cognition Disorders/*etiology
MH  - Diabetes Mellitus, Type 2/pathology
MH  - Humans
MH  - Insulin Resistance
MH  - Metabolic Syndrome/*complications/*pathology
MH  - Reactive Oxygen Species/metabolism
OTO - NOTNLM
OT  - International Diabetic Federation (IDF)
OT  - Metabolic syndrome
OT  - brain effect
OT  - diagnosis
OT  - insulin resistance
OT  - possible pathology.
EDAT- 2018/07/27 06:00
MHDA- 2019/10/12 06:00
CRDT- 2018/07/27 06:00
PHST- 2018/03/23 00:00 [received]
PHST- 2018/07/02 00:00 [revised]
PHST- 2018/07/03 00:00 [accepted]
PHST- 2018/07/27 06:00 [pubmed]
PHST- 2019/10/12 06:00 [medline]
PHST- 2018/07/27 06:00 [entrez]
AID - CNSNDDT-EPUB-91933 [pii]
AID - 10.2174/1871527317666180724143258 [doi]
PST - ppublish
SO  - CNS Neurol Disord Drug Targets. 2018;17(8):595-603. doi: 
      10.2174/1871527317666180724143258.