PMID- 30049949
OWN - NLM
STAT- MEDLINE
DCOM- 20181126
LR  - 20181126
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 10
IP  - 8
DP  - 2018 Jul 26
TI  - Medium-Chain Triglycerides Lower Blood Lipids and Body Weight in 
      Streptozotocin-Induced Type 2 Diabetes Rats.
LID - 10.3390/nu10080963 [doi]
LID - 963
AB  - Medium-chain triglycerides (MCTs) are distinguished from other triglycerides in 
      that each fat molecule consists of 6 to 12 carbons in length. MCTs and long-chain 
      triglycerides (LCTs) are absorbed and utilized in different ways. The aim of this 
      study was to assess the effects of replacing soybean oil with MCT oil, in a low- 
      or high-fat diet, on lipid metabolism in rats with streptozotocin-induced type 2 
      diabetes mellitus (T2DM). There were, thirty-two T2DM Sprague-Dawley rats divided 
      into low-fat-soybean oil (LS), low-fat-MCT oil (LM), high-fat-soybean oil (HS), 
      and high-fat-MCT oil (HM) groups. After 8 weeks, blood sugar, serum lipids, liver 
      lipids, and enzyme activities related to lipid metabolism were measured. Under a 
      high-fat diet condition, replacement of soybean oil with MCT oil lowered serum 
      low-density lipoprotein cholesterol (LDL-C), non-esterified fatty acids, and 
      liver total cholesterol; whilst it increased serum high-density lipoprotein 
      cholesterol (HDL-C) and the HDL-C/LDL-C ratio. A low-fat diet with MCT oil 
      resulted in lower body weight and reproductive white adipose tissues compared to 
      the HS groups, and higher hepatic acyl-CoA oxidase activities (the key enzyme in 
      the peroxisomal beta-oxidation) compared to the LS group in T2DM rats. In 
      conclusion, MCTs showed more protective effects on cardiovascular health in T2DM 
      rats fed a high-fat diet, by improving serum lipid profiles and reducing hepatic 
      total cholesterol.
FAU - Sung, Ming-Hua
AU  - Sung MH
AD  - School of Nutrition and Health Sciences, Taipei Medical University, Taipei 11031, 
      Taiwan. Glycine1016@hotmail.com.
FAU - Liao, Fang-Hsuean
AU  - Liao FH
AUID- ORCID: 0000-0001-5085-3763
AD  - School of Nutrition and Health Sciences, Taipei Medical University, Taipei 11031, 
      Taiwan. function0727@gmail.com.
FAU - Chien, Yi-Wen
AU  - Chien YW
AUID- ORCID: 0000-0002-7293-5310
AD  - School of Nutrition and Health Sciences, Taipei Medical University, Taipei 11031, 
      Taiwan. ychien@tmu.edu.tw.
AD  - Research Center of Geriatric Nutrition, College of Nutrition, Taipei Medical 
      University, Taipei 11031, Taiwan. ychien@tmu.edu.tw.
AD  - Graduate Institute of Metabolism and Obesity Sciences, Taipei Medical University, 
      Taipei 11031, Taiwan. ychien@tmu.edu.tw.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20180726
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Cholesterol, HDL)
RN  - 0 (Cholesterol, LDL)
RN  - 0 (Insulin)
RN  - 0 (Triglycerides)
RN  - 5W494URQ81 (Streptozocin)
RN  - 8001-22-7 (Soybean Oil)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Adipose Tissue, White/metabolism/physiopathology
MH  - Adiposity
MH  - Animals
MH  - Biomarkers/blood
MH  - Blood Glucose/metabolism
MH  - Cholesterol/*blood
MH  - Cholesterol, HDL/blood
MH  - Cholesterol, LDL/blood
MH  - Diabetes Mellitus, Experimental/blood/chemically induced/*diet 
      therapy/physiopathology
MH  - Diabetes Mellitus, Type 2/blood/chemically induced/*diet therapy/physiopathology
MH  - Diet, High-Fat
MH  - Insulin/blood
MH  - Liver/metabolism
MH  - Male
MH  - Rats, Sprague-Dawley
MH  - Soybean Oil/*administration & dosage
MH  - *Streptozocin
MH  - Triglycerides/*administration & dosage
MH  - *Weight Loss
PMC - PMC6115836
OTO - NOTNLM
OT  - lipid metabolism
OT  - long-chain triglyceride
OT  - medium-chain triglyceride
OT  - type 2 diabetes mellitus
COIS- The authors declare no conflict of interest.
EDAT- 2018/07/28 06:00
MHDA- 2018/11/27 06:00
PMCR- 2018/08/01
CRDT- 2018/07/28 06:00
PHST- 2018/07/02 00:00 [received]
PHST- 2018/07/19 00:00 [revised]
PHST- 2018/07/24 00:00 [accepted]
PHST- 2018/07/28 06:00 [entrez]
PHST- 2018/07/28 06:00 [pubmed]
PHST- 2018/11/27 06:00 [medline]
PHST- 2018/08/01 00:00 [pmc-release]
AID - nu10080963 [pii]
AID - nutrients-10-00963 [pii]
AID - 10.3390/nu10080963 [doi]
PST - epublish
SO  - Nutrients. 2018 Jul 26;10(8):963. doi: 10.3390/nu10080963.