PMID- 30050150
OWN - NLM
STAT- MEDLINE
DCOM- 20191022
LR  - 20191022
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 8
IP  - 1
DP  - 2018 Jul 26
TI  - Small litter size impairs spatial memory and increases anxiety- like behavior in 
      a strain-dependent manner in male mice.
PG  - 11281
LID - 10.1038/s41598-018-29595-0 [doi]
LID - 11281
AB  - Early life overfeeding is associated with cognitive decline and anxiety-like 
      behaviors in later life. It is not clear whether there are individual differences 
      in the effects of early life overfeeding and what the underlying mechanistic 
      pathways are. We investigated the long-lasting effects of small litter size, an 
      experimental manipulation to induce neonatal overfeeding, in two strains of mice, 
      C57BL/6 and NMRI. We measured body weight, learning and memory, anxiety-related 
      behaviors, interleukin-(IL)-1beta and brain-derived-neurotrophic-factor (BDNF) 
      levels in the hippocampus, and both basal and stress corticosterone levels in 
      adult mice which have been nursed in small litters compared with those from 
      control litters. Our findings showed that small litter size led to increased body 
      weight in both strains of mice. Small litter size significantly decreased spatial 
      memory and hippocampal BDNF levels, and increased hippocampal IL-1beta, in NMRI 
      mice, but not C57BL/6 mice. Interestingly, we found that small litter size 
      resulted in a significant increase in anxiety-like behaviors and stress-induced 
      corticosterone in NMRI mice, whereas small litter size reduced anxiety-like 
      symptoms and stress-induced corticosterone levels in C57BL/6 mice. These data 
      show that small litter size, which is life-long associated with increased body 
      weight, affects memory and anxiety-related behaviors in a strain-dependent manner 
      in male mice. This suggests that there are individual differences in the 
      developmental consequences of early life overfeeding.
FAU - Salari, Ali-Akbar
AU  - Salari AA
AUID- ORCID: 0000-0002-4970-0337
AD  - Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, 
      Iran. aa.salari@yahoo.com.
AD  - Salari Institute of Cognitive and Behavioral Disorders (SICBD), Alborz, Karaj, 
      Iran. aa.salari@yahoo.com.
FAU - Samadi, Hanieh
AU  - Samadi H
AD  - Salari Institute of Cognitive and Behavioral Disorders (SICBD), Alborz, Karaj, 
      Iran.
FAU - Homberg, Judith R
AU  - Homberg JR
AD  - Department of Cognitive Neuroscience, Centre for Neuroscience, Donders Institute 
      for Brain, Cognition, and Behaviour, Radboud University Medical Centre, Nijmegen, 
      The Netherlands.
FAU - Kosari-Nasab, Morteza
AU  - Kosari-Nasab M
AD  - Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, 
      Iran.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180726
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Bdnf protein, mouse)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Interleukin-1beta)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Animals
MH  - *Anxiety
MH  - *Behavior, Animal
MH  - Blood Chemical Analysis
MH  - Body Weight
MH  - Brain-Derived Neurotrophic Factor/analysis
MH  - Corticosterone/blood
MH  - Hippocampus/pathology
MH  - Interleukin-1beta/analysis
MH  - *Litter Size
MH  - Male
MH  - Mice
MH  - *Spatial Memory
PMC - PMC6062575
COIS- The authors declare no competing interests.
EDAT- 2018/07/28 06:00
MHDA- 2019/10/23 06:00
PMCR- 2018/07/26
CRDT- 2018/07/28 06:00
PHST- 2018/02/09 00:00 [received]
PHST- 2018/07/16 00:00 [accepted]
PHST- 2018/07/28 06:00 [entrez]
PHST- 2018/07/28 06:00 [pubmed]
PHST- 2019/10/23 06:00 [medline]
PHST- 2018/07/26 00:00 [pmc-release]
AID - 10.1038/s41598-018-29595-0 [pii]
AID - 29595 [pii]
AID - 10.1038/s41598-018-29595-0 [doi]
PST - epublish
SO  - Sci Rep. 2018 Jul 26;8(1):11281. doi: 10.1038/s41598-018-29595-0.