PMID- 30050466
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1664-042X (Print)
IS  - 1664-042X (Electronic)
IS  - 1664-042X (Linking)
VI  - 9
DP  - 2018
TI  - Increased Serum Interleukin-34 Levels Are Related to the Presence and Severity of 
      Cardiac Dysfunction in Patients With Ischemic Cardiomyopathy.
PG  - 904
LID - 10.3389/fphys.2018.00904 [doi]
LID - 904
AB  - Background: Several inflammatory factors have been demonstrated with diagnostic 
      or prognostic value in patients with ischemic cardiomyopathy (ICM). Interleukin 
      34 (IL-34), an additional ligand of colony stimulating factor-1 receptor 
      (CSF-1R), has been identified as a biomarker of coronary artery disease (CAD) and 
      chronic kidney disease (CKD). However, the potential effect of IL-34 in ICM 
      remains unknown. Methods: Serum IL-34 levels were detected in 360 subjects with 
      ICM and in 465 subjects without ICM; the latter group included 233 controls 
      without CAD and 232 patients with CAD and normal cardiac function. Uni- and 
      multivariable logistic regression analyses were conducted to analyze the 
      relationship between IL-34 and ICM. Results: IL-34 levels were significantly 
      increased in patients with ICM compared with both groups of subjects without ICM 
      (122.52 +/- 115.30 vs. 95.02 +/- 101.43 vs. 82.57 +/- 84.24 pg/ml, respectively; P < 
      0.001). Moreover, serum IL-34 level was significantly positively correlated to 
      NT-proBNP level (r = 0.223, P < 0.001), left ventricular end diastolic diameter 
      and New York Heart Association (NYHA) functional class, indicating that a higher 
      IL-34 level reflects more severe heart failure (HF). Multivariable regression 
      analyses revealed that IL-34 was remarkably associated with the presence and 
      severity of ICM after adjusting for age, sex, conventional risk factors as well 
      as medication [odds ratio (OR): 1.501, 95% confidence interval (CI): 1.249-1.803, 
      P < 0.001, per SD increase]. The predictive value of IL-34 value remained 
      significant in patients already diagnosed with CAD. Conclusion: Increased IL-34 
      levels are relevant to the presence and severity of ischemic HF in all subjects 
      and in patients with CAD. IL-34 may be used as a novel clinical biomarker of ICM 
      with predictive value.
FAU - Xi, Rui
AU  - Xi R
AD  - Department of Cardiology, Ruijin Hospital, Shanghai Jiao Tong University School 
      of Medicine, Shanghai, China.
FAU - Fan, Qin
AU  - Fan Q
AD  - Department of Cardiology, Ruijin Hospital, Shanghai Jiao Tong University School 
      of Medicine, Shanghai, China.
AD  - Institute of Cardiovascular Diseases, Shanghai Jiao Tong University School of 
      Medicine, Shanghai, China.
FAU - Yan, Xiaoxiang
AU  - Yan X
AD  - Department of Cardiology, Ruijin Hospital, Shanghai Jiao Tong University School 
      of Medicine, Shanghai, China.
AD  - Institute of Cardiovascular Diseases, Shanghai Jiao Tong University School of 
      Medicine, Shanghai, China.
FAU - Zhang, Hang
AU  - Zhang H
AD  - Department of Cardiology, Ruijin Hospital, Shanghai Jiao Tong University School 
      of Medicine, Shanghai, China.
AD  - Institute of Cardiovascular Diseases, Shanghai Jiao Tong University School of 
      Medicine, Shanghai, China.
FAU - Xie, Hongyang
AU  - Xie H
AD  - Department of Cardiology, Ruijin Hospital, Shanghai Jiao Tong University School 
      of Medicine, Shanghai, China.
AD  - Institute of Cardiovascular Diseases, Shanghai Jiao Tong University School of 
      Medicine, Shanghai, China.
FAU - Gu, Gang
AU  - Gu G
AD  - Department of Cardiology, Ruijin Hospital, Shanghai Jiao Tong University School 
      of Medicine, Shanghai, China.
FAU - Xu, Yan
AU  - Xu Y
AD  - Department of Cardiology, Ruijin Hospital, Shanghai Jiao Tong University School 
      of Medicine, Shanghai, China.
FAU - Wang, Fang
AU  - Wang F
AD  - Department of Cardiology, Ruijin Hospital, Shanghai Jiao Tong University School 
      of Medicine, Shanghai, China.
FAU - Tao, Rong
AU  - Tao R
AD  - Department of Cardiology, Ruijin Hospital, Shanghai Jiao Tong University School 
      of Medicine, Shanghai, China.
LA  - eng
PT  - Journal Article
DEP - 20180711
PL  - Switzerland
TA  - Front Physiol
JT  - Frontiers in physiology
JID - 101549006
PMC - PMC6050385
OTO - NOTNLM
OT  - coronary artery disease
OT  - heart failure
OT  - inflammation
OT  - interleukin 34
OT  - ischemic cardiomyopathy
EDAT- 2018/07/28 06:00
MHDA- 2018/07/28 06:01
PMCR- 2018/07/11
CRDT- 2018/07/28 06:00
PHST- 2018/03/06 00:00 [received]
PHST- 2018/06/21 00:00 [accepted]
PHST- 2018/07/28 06:00 [entrez]
PHST- 2018/07/28 06:00 [pubmed]
PHST- 2018/07/28 06:01 [medline]
PHST- 2018/07/11 00:00 [pmc-release]
AID - 10.3389/fphys.2018.00904 [doi]
PST - epublish
SO  - Front Physiol. 2018 Jul 11;9:904. doi: 10.3389/fphys.2018.00904. eCollection 
      2018.