PMID- 30050496
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1664-2295 (Print)
IS  - 1664-2295 (Electronic)
IS  - 1664-2295 (Linking)
VI  - 9
DP  - 2018
TI  - Impaired Sensorimotor Integration in Restless Legs Syndrome.
PG  - 568
LID - 10.3389/fneur.2018.00568 [doi]
LID - 568
AB  - Objective: Restless legs syndrome (RLS) is a complicated sensorimotor syndrome 
      that may be linked to changes in sensorimotor integration. The mechanism of such 
      changes is unclear. The aim of this study was to investigate sensorimotor 
      integration in patients with RLS through transcranial magnetic stimulation-motor 
      evoked potentials (TMS-MEPs) preceded by peripheral electric stimulation. 
      Methods: Fourteen RLS patients and 12 healthy, age-matched controls were 
      investigated. The clinical severity of RLS was evaluated based on the 
      International Criteria of the International Restless Legs Syndrome Study Group 
      (IRLSSG) severity scores. The tibial and median H-reflexes and the resting motor 
      threshold (RMT) of the abductor pollicis brevis (APB) were tested in all 26 
      subjects. The RMT of the tibialis anterior (TA) was tested in 8 patients and 7 
      controls. All 26 subjects underwent measurement of unconditioned MEPs of the APB. 
      Electric pulses were applied to the right median nerve, followed by TMS pulses 
      over the left motor cortex at interstimulus intervals (ISIs) of 20, 25, 30, 50, 
      100, 150, and 200 ms. Unconditioned MEPs of the TA were measured in 8 patients 
      and 7 controls. Electric pulses were applied to the right peroneal nerve, 
      followed by TMS pulses over the left motor cortex at ISIs of 30, 35, 45, 60, 100, 
      and 200 ms. The degree of modulation of MEPs by electric stimulation was 
      expressed as the ratio of the conditioned MEP amplitude to the unconditioned MEP 
      amplitude. Ratios <1 indicated inhibition, and ratios >1 indicated facilitation. 
      Results: No significant differences in RMT or H-reflex latencies or amplitudes 
      were found between RLS patients and controls. A significant increase in 
      unconditioned MEP amplitudes of the TA was observed in patients compared to 
      controls (p = 0.03). Long-latency afferent inhibition (LAI) of the median nerve 
      in RLS patients was decreased significantly at ISIs of 150 (p = 0.000) and 200 ms 
      (p = 0.004). Upon peroneal nerve stimulation, no significant difference was 
      observed between the two groups at any ISI. Conclusions: Our results suggest 
      increased motor cortical excitability of the legs and disturbed sensorimotor 
      integration in RLS patients; this disturbance might originate at the cortical 
      level.
FAU - Lin, Yicong
AU  - Lin Y
AD  - Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 
      China.
AD  - Beijing Key Laboratory of Neuromodulation, Beijing, China.
FAU - Wang, Yijin
AU  - Wang Y
AD  - Department of Neurology, Beijing Renhe Hospital, Beijing, China.
FAU - Zhan, Shuqin
AU  - Zhan S
AD  - Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 
      China.
AD  - Beijing Key Laboratory of Neuromodulation, Beijing, China.
FAU - Ding, Yan
AU  - Ding Y
AD  - Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 
      China.
AD  - Beijing Key Laboratory of Neuromodulation, Beijing, China.
FAU - Hou, Yue
AU  - Hou Y
AD  - Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 
      China.
AD  - Beijing Key Laboratory of Neuromodulation, Beijing, China.
FAU - Wang, Li
AU  - Wang L
AD  - Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 
      China.
AD  - Beijing Key Laboratory of Neuromodulation, Beijing, China.
FAU - Wang, Yuping
AU  - Wang Y
AD  - Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 
      China.
AD  - Beijing Key Laboratory of Neuromodulation, Beijing, China.
AD  - Center of Epilepsy, Beijing Institute for Brain Disorders, Capital Medical 
      University, Beijing, China.
LA  - eng
GR  - K99 AA020514/AA/NIAAA NIH HHS/United States
GR  - R00 AA020514/AA/NIAAA NIH HHS/United States
PT  - Journal Article
DEP - 20180711
PL  - Switzerland
TA  - Front Neurol
JT  - Frontiers in neurology
JID - 101546899
PMC - PMC6050383
OTO - NOTNLM
OT  - long latency afferent inhibition
OT  - restless legs syndrome
OT  - sensorimotor integration
OT  - short latency afferent inhibition
OT  - transcranial magnetic stimulation
EDAT- 2018/07/28 06:00
MHDA- 2018/07/28 06:01
PMCR- 2018/07/11
CRDT- 2018/07/28 06:00
PHST- 2017/11/16 00:00 [received]
PHST- 2018/06/25 00:00 [accepted]
PHST- 2018/07/28 06:00 [entrez]
PHST- 2018/07/28 06:00 [pubmed]
PHST- 2018/07/28 06:01 [medline]
PHST- 2018/07/11 00:00 [pmc-release]
AID - 10.3389/fneur.2018.00568 [doi]
PST - epublish
SO  - Front Neurol. 2018 Jul 11;9:568. doi: 10.3389/fneur.2018.00568. eCollection 2018.