PMID- 30050931
OWN - NLM
STAT- MEDLINE
DCOM- 20190114
LR  - 20230926
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2018
DP  - 2018
TI  - The Human Carbonic Anhydrase II in Platelets: An Underestimated Field of Its 
      Activity.
PG  - 4548353
LID - 10.1155/2018/4548353 [doi]
LID - 4548353
AB  - Carbonic anhydrases constitute a group of enzymes that catalyse reversible 
      hydration of carbon dioxide leading to the formation of bicarbonate and proton. 
      The platelet carbonic anhydrase II (CAII) was described for the first time in the 
      '80s of the last century. Nevertheless, its direct role in platelet physiology 
      and pathology still remains poorly understood. The modulation of platelet CAII 
      action as a therapeutic approach holds promise as a novel strategy to reduce the 
      impact of cardiovascular diseases. This short review paper summarises the current 
      knowledge regarding the role of human CAII in regulating platelet function. The 
      potential future directions considering this enzyme as a potential drug target 
      and important pathophysiological chain in platelet-related disorders are 
      described.
FAU - Jakubowski, Maciej
AU  - Jakubowski M
AUID- ORCID: 0000-0002-0074-1568
AD  - Department of Internal Medicine, Occupational Diseases and Hypertension, Wroclaw 
      Medical University, Borowska 213, 50-556 Wroclaw, Poland.
FAU - Szahidewicz-Krupska, Ewa
AU  - Szahidewicz-Krupska E
AUID- ORCID: 0000-0002-4446-6991
AD  - Department of Internal Medicine, Occupational Diseases and Hypertension, Wroclaw 
      Medical University, Borowska 213, 50-556 Wroclaw, Poland.
FAU - Doroszko, Adrian
AU  - Doroszko A
AUID- ORCID: 0000-0001-5472-028X
AD  - Department of Internal Medicine, Occupational Diseases and Hypertension, Wroclaw 
      Medical University, Borowska 213, 50-556 Wroclaw, Poland.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180628
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - 0 (Bicarbonates)
RN  - 0 (Protons)
RN  - EC 4.2.1.- (Carbonic Anhydrase II)
RN  - EC 4.2.1.1 (Carbonic Anhydrases)
SB  - IM
MH  - Bicarbonates
MH  - Blood Platelets/*physiology
MH  - Carbonic Anhydrase II/*physiology
MH  - Carbonic Anhydrases
MH  - Humans
MH  - Protons
PMC - PMC6046183
EDAT- 2018/07/28 06:00
MHDA- 2019/01/15 06:00
PMCR- 2018/06/28
CRDT- 2018/07/28 06:00
PHST- 2018/04/15 00:00 [received]
PHST- 2018/05/24 00:00 [accepted]
PHST- 2018/07/28 06:00 [entrez]
PHST- 2018/07/28 06:00 [pubmed]
PHST- 2019/01/15 06:00 [medline]
PHST- 2018/06/28 00:00 [pmc-release]
AID - 10.1155/2018/4548353 [doi]
PST - epublish
SO  - Biomed Res Int. 2018 Jun 28;2018:4548353. doi: 10.1155/2018/4548353. eCollection 
      2018.