PMID- 30052100
OWN - NLM
STAT- MEDLINE
DCOM- 20181218
LR  - 20181218
IS  - 2058-7384 (Electronic)
IS  - 0394-6320 (Print)
IS  - 0394-6320 (Linking)
VI  - 32
DP  - 2018 Jan-Dec
TI  - Characteristic patterns of HLA presentation and T cell differentiation in 
      adult-onset Still's disease.
PG  - 2058738418791284
LID - 10.1177/2058738418791284 [doi]
LID - 2058738418791284
AB  - We examined the expression of human leukocyte antigen (HLA) and composition of 
      differentiated T cells in the peripheral blood to understand the characteristics 
      of the immune changes in patients with adult-onset Still's disease (AOSD). This 
      study enrolled patients with AOSD (n = 14), patients with rheumatoid arthritis 
      (RA, n = 20), and healthy controls (HC, n = 20). The percentage of 
      surface-stained cells with HLA-DP, DQ, and DR alleles and the composition of 
      differentiated T cells in peripheral blood leukocytes (PBLs) were evaluated by 
      flow cytometry. AOSD patients exhibited significantly higher percentages of 
      lymphocytes presenting HLA-DP and HLA-DR, and lower percentages of cells 
      presenting HLA-DQ, than RA patients or HC. The proportions of CD4+, CD4+CCR7+, 
      CD4+CD62L-, and CD8+CD62L- cells from PBLs were decreased in AOSD patients 
      relative to RA patients or HCs. By contrast, AOSD patients had higher proportions 
      of CD8+naive T cells in whole blood relative to RA patients or HC. The 
      proportions of CD4+ effector memory T cells, CD8+ naive T cells, and CD8+ 
      effector memory T cells in whole blood cells and CD4+ effector memory T cell in 
      lymphocytes were significantly associated with the systemic score. While the 
      proportions of CD4+, CD8+, CCR7+, CD4+CCR7+, CD4+CD62L-, and CD8+CD62L- cells 
      were significantly decreased in AOSD patients, and the proportion of CD8+naive T 
      cells was elevated in AOSD and correlated with the systemic score. Further 
      studies of a large cohort of AOSD patients will be necessary to evaluate these 
      markers in the pathogenesis of AOSD.
FAU - Jung, Ju-Yang
AU  - Jung JY
AD  - 1 Department of Rheumatology, School of Medicine, Ajou University, Suwon, Korea.
FAU - Choi, Bunsoon
AU  - Choi B
AD  - 2 Department of Microbiology, School of Medicine, Ajou University, Suwon, Korea.
FAU - Sayeed, Hasan Md
AU  - Sayeed HM
AUID- ORCID: 0000-0002-1090-7322
AD  - 3 Department of Biomedical Science, School of Medicine, Ajou University, Suwon, 
      Korea.
FAU - Suh, Chang-Hee
AU  - Suh CH
AD  - 1 Department of Rheumatology, School of Medicine, Ajou University, Suwon, Korea.
FAU - Kim, Ye Won
AU  - Kim YW
AUID- ORCID: 0000-0003-2609-3367
AD  - 1 Department of Rheumatology, School of Medicine, Ajou University, Suwon, Korea.
FAU - Kim, Hyoun-Ah
AU  - Kim HA
AD  - 1 Department of Rheumatology, School of Medicine, Ajou University, Suwon, Korea.
FAU - Sohn, Seonghyang
AU  - Sohn S
AD  - 2 Department of Microbiology, School of Medicine, Ajou University, Suwon, Korea.
AD  - 3 Department of Biomedical Science, School of Medicine, Ajou University, Suwon, 
      Korea.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Int J Immunopathol Pharmacol
JT  - International journal of immunopathology and pharmacology
JID - 8911335
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cell Differentiation
MH  - Female
MH  - HLA Antigens/*immunology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Still's Disease, Adult-Onset/*immunology
MH  - T-Lymphocytes/cytology/*immunology
PMC - PMC6073833
OTO - NOTNLM
OT  - T cell
OT  - adult-onset still's disease
OT  - biomarker
OT  - disease activity
OT  - human leukocyte antigen
COIS- Declaration of conflicting interests: The author(s) declared no potential 
      conflicts of interest with respect to the research, authorship, and/or 
      publication of this article.
EDAT- 2018/07/28 06:00
MHDA- 2018/12/19 06:00
PMCR- 2018/07/27
CRDT- 2018/07/28 06:00
PHST- 2018/07/28 06:00 [entrez]
PHST- 2018/07/28 06:00 [pubmed]
PHST- 2018/12/19 06:00 [medline]
PHST- 2018/07/27 00:00 [pmc-release]
AID - 10.1177_2058738418791284 [pii]
AID - 10.1177/2058738418791284 [doi]
PST - ppublish
SO  - Int J Immunopathol Pharmacol. 2018 Jan-Dec;32:2058738418791284. doi: 
      10.1177/2058738418791284.