PMID- 30052197
OWN - NLM
STAT- MEDLINE
DCOM- 20190226
LR  - 20200227
IS  - 2050-084X (Electronic)
IS  - 2050-084X (Linking)
VI  - 7
DP  - 2018 Jul 27
TI  - NPAS4 recruits CCK basket cell synapses and enhances cannabinoid-sensitive 
      inhibition in the mouse hippocampus.
LID - 10.7554/eLife.35927 [doi]
LID - e35927
AB  - Experience-dependent expression of immediate-early gene transcription factors 
      (IEG-TFs) can transiently change the transcriptome of active neurons and initiate 
      persistent changes in cellular function. However, the impact of IEG-TFs on 
      circuit connectivity and function is poorly understood. We investigate the 
      specificity with which the IEG-TF NPAS4 governs experience-dependent changes in 
      inhibitory synaptic input onto CA1 pyramidal neurons (PNs). We show that novel 
      sensory experience selectively enhances somatic inhibition mediated by 
      cholecystokinin-expressing basket cells (CCKBCs) in an NPAS4-dependent manner. 
      NPAS4 specifically increases the number of synapses made onto PNs by individual 
      CCKBCs without altering synaptic properties. Additionally, we find that sensory 
      experience-driven NPAS4 expression enhances depolarization-induced suppression of 
      inhibition (DSI), a short-term form of cannabinoid-mediated plasticity expressed 
      at CCKBC synapses. Our results indicate that CCKBC inputs are a major target of 
      the NPAS4-dependent transcriptional program in PNs and that NPAS4 is an important 
      regulator of plasticity mediated by endogenous cannabinoids.
CI  - (c) 2018, Hartzell et al.
FAU - Hartzell, Andrea L
AU  - Hartzell AL
AUID- ORCID: 0000-0002-6202-6148
AD  - Neuroscience Graduate Program, Center for Neural Circuits and Behavior, 
      University of California San Diego, San Diego, United States.
AD  - Division of Biological Sciences, Section of Neurobiology, Center for Neural 
      Circuits and Behavior, University of California San Diego, San Diego, United 
      States.
FAU - Martyniuk, Kelly M
AU  - Martyniuk KM
AD  - Division of Biological Sciences, Section of Neurobiology, Center for Neural 
      Circuits and Behavior, University of California San Diego, San Diego, United 
      States.
FAU - Brigidi, G Stefano
AU  - Brigidi GS
AD  - Division of Biological Sciences, Section of Neurobiology, Center for Neural 
      Circuits and Behavior, University of California San Diego, San Diego, United 
      States.
FAU - Heinz, Daniel A
AU  - Heinz DA
AD  - Division of Biological Sciences, Section of Neurobiology, Center for Neural 
      Circuits and Behavior, University of California San Diego, San Diego, United 
      States.
AD  - Biological Sciences Graduate Program, Center for Neural Circuits and Behavior, 
      University of California San Diego, San Diego, United States.
FAU - Djaja, Nathalie A
AU  - Djaja NA
AD  - Division of Biological Sciences, Section of Neurobiology, Center for Neural 
      Circuits and Behavior, University of California San Diego, San Diego, United 
      States.
FAU - Payne, Anja
AU  - Payne A
AD  - Neuroscience Graduate Program, Center for Neural Circuits and Behavior, 
      University of California San Diego, San Diego, United States.
AD  - Division of Biological Sciences, Section of Neurobiology, Center for Neural 
      Circuits and Behavior, University of California San Diego, San Diego, United 
      States.
FAU - Bloodgood, Brenda L
AU  - Bloodgood BL
AUID- ORCID: 0000-0002-4797-9119
AD  - Neuroscience Graduate Program, Center for Neural Circuits and Behavior, 
      University of California San Diego, San Diego, United States.
AD  - Division of Biological Sciences, Section of Neurobiology, Center for Neural 
      Circuits and Behavior, University of California San Diego, San Diego, United 
      States.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20180727
PL  - England
TA  - Elife
JT  - eLife
JID - 101579614
RN  - 0 (Basic Helix-Loop-Helix Transcription Factors)
RN  - 0 (Cannabinoids)
RN  - 0 (Npas4 protein, mouse)
RN  - 0 (Parvalbumins)
RN  - 9011-97-6 (Cholecystokinin)
SB  - IM
MH  - Animals
MH  - Basic Helix-Loop-Helix Transcription Factors/*metabolism
MH  - CA1 Region, Hippocampal/cytology
MH  - Cannabinoids/*pharmacology
MH  - Cell Differentiation/drug effects
MH  - Cholecystokinin/*metabolism
MH  - Hippocampus/*cytology
MH  - Interneurons/drug effects/metabolism
MH  - Mice, Inbred C57BL
MH  - Neural Inhibition/*drug effects
MH  - Parvalbumins/metabolism
MH  - Pyramidal Cells/drug effects/physiology
MH  - Synapses/drug effects/*metabolism
MH  - Synaptic Transmission/drug effects
PMC - PMC6105310
OTO - NOTNLM
OT  - CA1 pyramidal neuron
OT  - CCK basket cell
OT  - DSI
OT  - NPAS4
OT  - immediate early gene transcription factor
OT  - mouse
OT  - neuroscience
COIS- AH, KM, GB, DH, ND, AP, BB No competing interests declared
EDAT- 2018/07/28 06:00
MHDA- 2019/02/27 06:00
PMCR- 2018/07/27
CRDT- 2018/07/28 06:00
PHST- 2018/02/14 00:00 [received]
PHST- 2018/07/19 00:00 [accepted]
PHST- 2018/07/28 06:00 [pubmed]
PHST- 2019/02/27 06:00 [medline]
PHST- 2018/07/28 06:00 [entrez]
PHST- 2018/07/27 00:00 [pmc-release]
AID - 35927 [pii]
AID - 10.7554/eLife.35927 [doi]
PST - epublish
SO  - Elife. 2018 Jul 27;7:e35927. doi: 10.7554/eLife.35927.