PMID- 30052465
OWN - NLM
STAT- MEDLINE
DCOM- 20181108
LR  - 20181108
IS  - 1205-7541 (Electronic)
IS  - 0008-4212 (Linking)
VI  - 96
IP  - 9
DP  - 2018 Sep
TI  - Depression induced by chronic stress leads to penile cavernosal dysfunction: 
      protective effect of anti-TNF-alpha treatment.
PG  - 933-942
LID - 10.1139/cjpp-2017-0778 [doi]
AB  - Psychological stress may lead to erectile dysfunction (ED), and inflammation has 
      been evaluated as a major contributing factor. The goal of this study was to 
      investigate the effects of etanercept (ETN), an anti-tumor necrosis factor alpha 
      (TNF-alpha) protein, on cavernosal function in the unpredictable chronic mild stress 
      (UCMS) rat model of depression. Animals were divided into 4 groups: animals not 
      exposed to UCMS, animals not exposed to UCMS and treated with ETN, animals 
      exposed to UCMS, and animals treated with ETN while exposed to UCMS. UCMS 
      significantly impaired the neurogenic and endothelium-dependent relaxation 
      responses; reduced cavernosal endothelial nitric oxide (NO) synthase (eNOS) and 
      neuronal NO synthase (nNOS) expressions; decreased testosterone levels; enhanced 
      systemic levels of corticosterone, TNF-alpha, interleukin 1beta (IL-1beta), interleukin 6 
      (IL-6), monocyte chemoattractant protein-1 (MCP-1), and intercellular adhesion 
      molecule 1 (ICAM-1); and also increased cavernosal levels of TNF-alpha, IL-1beta, and 
      IL-6 in rats. ETN administration restored NO-mediated neurogenic and 
      endothelium-dependent relaxation responses of the corpus cavernosum, increased 
      cavernosal eNOS and nNOS expressions, enhanced testosterone levels, and decreased 
      corticosterone levels in UCMS-exposed rats. Also, systemic inflammatory markers 
      and cavernosal proinflammatory cytokine levels were reduced by ETN. Our results 
      demonstrate the role of TNF-alpha-mediated inflammation in the development of 
      depression and ED in rats exposed to chronic stress.
FAU - Demirtas Sahin, Tugce
AU  - Demirtas Sahin T
AD  - a Department of Pharmacology, Medical Faculty, Kocaeli University, Kocaeli, 
      Turkey.
FAU - Yazir, Yusufhan
AU  - Yazir Y
AD  - b Department of Histology and Embryology, Medical Faculty, Kocaeli University, 
      Kocaeli, Turkey.
AD  - c Stem Cell and Gene Therapy Research and Application Center, Kocaeli University, 
      Kocaeli, Turkey.
FAU - Utkan, Tijen
AU  - Utkan T
AD  - a Department of Pharmacology, Medical Faculty, Kocaeli University, Kocaeli, 
      Turkey.
FAU - Gacar, Gulcin
AU  - Gacar G
AD  - c Stem Cell and Gene Therapy Research and Application Center, Kocaeli University, 
      Kocaeli, Turkey.
FAU - Halbutogullari, Zehra Seda
AU  - Halbutogullari ZS
AD  - c Stem Cell and Gene Therapy Research and Application Center, Kocaeli University, 
      Kocaeli, Turkey.
FAU - Gocmez, Semil Selcen
AU  - Gocmez SS
AD  - a Department of Pharmacology, Medical Faculty, Kocaeli University, Kocaeli, 
      Turkey.
LA  - eng
PT  - Journal Article
DEP - 20180727
PL  - Canada
TA  - Can J Physiol Pharmacol
JT  - Canadian journal of physiology and pharmacology
JID - 0372712
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase Type I)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase Type III)
RN  - OP401G7OJC (Etanercept)
SB  - IM
MH  - Animals
MH  - Behavior, Animal
MH  - Body Weight
MH  - Depression/physiopathology/*psychology/*therapy
MH  - Endothelium/metabolism
MH  - Erectile Dysfunction/*psychology
MH  - Etanercept/*immunology/*therapeutic use
MH  - Gene Expression Regulation, Enzymologic
MH  - Locomotion
MH  - Male
MH  - Nitric Oxide Synthase Type I/genetics
MH  - Nitric Oxide Synthase Type III/genetics
MH  - Rats
MH  - Rats, Wistar
MH  - Stress, Psychological/*psychology
MH  - Time Factors
MH  - Tumor Necrosis Factor-alpha/*immunology
MH  - Vasodilation
OTO - NOTNLM
OT  - TNF-alpha
OT  - dysfonction erectile
OT  - erectile dysfunction
OT  - inflammation
OT  - stress leger imprevisible chronique
OT  - unpredictable chronic mild stress
EDAT- 2018/07/28 06:00
MHDA- 2018/11/09 06:00
CRDT- 2018/07/28 06:00
PHST- 2018/07/28 06:00 [pubmed]
PHST- 2018/11/09 06:00 [medline]
PHST- 2018/07/28 06:00 [entrez]
AID - 10.1139/cjpp-2017-0778 [doi]
PST - ppublish
SO  - Can J Physiol Pharmacol. 2018 Sep;96(9):933-942. doi: 10.1139/cjpp-2017-0778. 
      Epub 2018 Jul 27.