PMID- 30053467
OWN - NLM
STAT- MEDLINE
DCOM- 20190830
LR  - 20190830
IS  - 1879-1891 (Electronic)
IS  - 0002-9394 (Linking)
VI  - 194
DP  - 2018 Oct
TI  - Macular Damage, as Determined by Structure-Function Staging, Is Associated With 
      Worse Vision-related Quality of Life in Early Glaucoma.
PG  - 88-94
LID - S0002-9394(18)30392-1 [pii]
LID - 10.1016/j.ajo.2018.07.011 [doi]
AB  - PURPOSE: Macular damage is common early in glaucoma and has previously been 
      identified as a significant factor affecting vision-related quality of life 
      (VRQoL) across the spectrum of glaucomatous damage. This report uses 
      structure-function correlation to identify early macular damage and assess its 
      relationship with the National Eye Institute Visual Function Questionnaire (NEI 
      VFQ-25). DESIGN: Cohort study. METHODS: Setting: Institutional. STUDY POPULATION: 
      Eighty-eight eyes of 44 participants with early open-angle glaucoma (24-2 mean 
      deviation [MD] better than -6 dB). OBSERVATION PROCEDURE: Focal and diffuse 
      macular defects were identified based on corresponding abnormal regions on 
      probability maps from spectral-domain optical coherence tomography (SD-OCT) optic 
      disc and macular cube scans, and 10-2 and 24-2 visual fields (VF). MAIN OUTCOME 
      MEASURE: VRQoL, as measured by the NEI VFQ-25. RESULTS: Twenty-five of 44 (57%) 
      "worse" eyes (defined by 24-2 VF MD) and 13 of 44 (31%) "better" eyes had macular 
      damage. Mean (+/-standard deviation) MD of worse and better eyes were -3.03 dB 
      (+/-2.3) and -1.15 dB (+/-1.7), respectively. Compared to those without macular 
      damage, lower NEI VFQ-25 scores were seen in patients with macular damage in the 
      worse eye (85.4 [+/- 9.0] vs 94.6 [+/- 3.3]; P = .0001) and the better eye (84.8 [+/- 
      11.1] vs 91.3 [+/- 6.3]; P = .017). Arcuate damage outside the macula did not 
      affect VRQoL (better eye, P = .40; worse eye, P = .87). CONCLUSIONS: Early 
      glaucomatous macular damage, as detected by abnormal topographic regions on 
      measures of structure and function, is associated with decreased VRQoL. Arcuate 
      damage outside the macula does not have an association with VRQoL in early 
      glaucoma.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Garg, Aakriti
AU  - Garg A
AD  - Bernard and Shirlee Brown Glaucoma Research Laboratory, Edward S. Harkness Eye 
      Institute, Department of Ophthalmology, Columbia University Medical Center, New 
      York, New York, USA.
FAU - Hood, Donald C
AU  - Hood DC
AD  - Departments of Psychology and Ophthalmology, Columbia University, New York, New 
      York, USA.
FAU - Pensec, Noelle
AU  - Pensec N
AD  - Bernard and Shirlee Brown Glaucoma Research Laboratory, Edward S. Harkness Eye 
      Institute, Department of Ophthalmology, Columbia University Medical Center, New 
      York, New York, USA.
FAU - Liebmann, Jeffrey M
AU  - Liebmann JM
AD  - Bernard and Shirlee Brown Glaucoma Research Laboratory, Edward S. Harkness Eye 
      Institute, Department of Ophthalmology, Columbia University Medical Center, New 
      York, New York, USA.
FAU - Blumberg, Dana M
AU  - Blumberg DM
AD  - Bernard and Shirlee Brown Glaucoma Research Laboratory, Edward S. Harkness Eye 
      Institute, Department of Ophthalmology, Columbia University Medical Center, New 
      York, New York, USA. Electronic address: dmb2196@columbia.edu.
LA  - eng
GR  - R01 EY002115/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20180725
PL  - United States
TA  - Am J Ophthalmol
JT  - American journal of ophthalmology
JID - 0370500
SB  - IM
MH  - Aged
MH  - Cohort Studies
MH  - Female
MH  - Glaucoma, Open-Angle/*diagnosis/psychology
MH  - Gonioscopy
MH  - Humans
MH  - Intraocular Pressure/physiology
MH  - Macula Lutea/*pathology
MH  - Male
MH  - Middle Aged
MH  - Ophthalmoscopy
MH  - Prospective Studies
MH  - Quality of Life/*psychology
MH  - Retinal Diseases/*diagnosis/psychology
MH  - Sensitivity and Specificity
MH  - *Sickness Impact Profile
MH  - Slit Lamp Microscopy
MH  - Surveys and Questionnaires
MH  - Tomography, Optical Coherence/methods
MH  - Vision Disorders/*diagnosis/psychology
MH  - Visual Acuity/physiology
MH  - Visual Field Tests
EDAT- 2018/07/28 06:00
MHDA- 2019/08/31 06:00
CRDT- 2018/07/28 06:00
PHST- 2018/05/07 00:00 [received]
PHST- 2018/07/08 00:00 [revised]
PHST- 2018/07/11 00:00 [accepted]
PHST- 2018/07/28 06:00 [pubmed]
PHST- 2019/08/31 06:00 [medline]
PHST- 2018/07/28 06:00 [entrez]
AID - S0002-9394(18)30392-1 [pii]
AID - 10.1016/j.ajo.2018.07.011 [doi]
PST - ppublish
SO  - Am J Ophthalmol. 2018 Oct;194:88-94. doi: 10.1016/j.ajo.2018.07.011. Epub 2018 
      Jul 25.