PMID- 30054124
OWN - NLM
STAT- MEDLINE
DCOM- 20191127
LR  - 20191127
IS  - 1444-2892 (Electronic)
IS  - 1443-9506 (Linking)
VI  - 28
IP  - 7
DP  - 2019 Jul
TI  - Long-Term Survival and Health-Related Quality of Life in Adults After Extra 
      Corporeal Membrane Oxygenation.
PG  - 1090-1098
LID - S1443-9506(18)31795-5 [pii]
LID - 10.1016/j.hlc.2018.06.1044 [doi]
AB  - BACKGROUND: The study aims to determine long-term survival, health-related 
      quality of life (HRQoL) and functional and physical outcomes of adult extra 
      corporeal membrane oxygenation (ECMO) patients as there are limited and 
      conflicting data in this area. METHODS: All patients receiving ECMO from April 
      2009 until June 2014 at The Prince Charles Hospital, Brisbane had Kaplan Meier 
      survival calculated. Quality of life (QoL) was assessed using the Short Form 
      Health Survey (SF-36v2), EQ5D-5L, The Frenchay Activities Index (FAI) and a 
      return to work survey. From December 2011, these measures and 6-minute walk 
      distance (6MWD) were assessed at hospital discharge and 12 months post-discharge. 
      RESULTS: Seventy-seven (77) patients (45 veno-arterial and 32 veno-venous) 
      received ECMO of whom 47/77 (61%) survived to hospital discharge. There were no 
      deaths recorded in those discharged alive from the intensive care unit at median 
      follow-up time 1,011days (range 227-2,014 days). Mean SF-36 scores (n=33) and 
      EQ5D were assessed at a median of 606days after hospital discharge. SF-36 scores 
      were significantly (p<0.05) worse than age-matched norms in all domains except 
      vitality, bodily pain and mental health. Thirteen (13) (39%) participants had 
      persistent problems with mobility and usual activity as measured by EQ5D. At 12 
      months post-ECMO, 6MWD was 531(IQR:397.3-626.8)m; 72% (IQR:53.2-77.6%) predicted 
      but had improved by 223m (p=0.002) when compared to baseline. Nineteen (19) of 20 
      participants who had been employed pre-ECMO had returned to work. CONCLUSIONS: 
      All ECMO patients discharged from hospital were alive at follow-up. Despite 
      improvements in physical measures and HRQoL, long-term functional deficits 
      persist when compared to that of aged- and sex-matched norms.
CI  - Copyright (c) 2018 Australian and New Zealand Society of Cardiac and Thoracic 
      Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ). 
      All rights reserved.
FAU - Roll, Mark A
AU  - Roll MA
AD  - Physiotherapy Department, The Prince Charles Hospital, Brisbane, Qld, Australia. 
      Electronic address: mark.roll@health.qld.gov.au.
FAU - Kuys, Suzanne
AU  - Kuys S
AD  - Physiotherapy Department, The Prince Charles Hospital, Brisbane, Qld, Australia; 
      School of Physiotherapy, Australian Catholic University, Brisbane, Qld, 
      Australia.
FAU - Walsh, James R
AU  - Walsh JR
AD  - Physiotherapy Department, The Prince Charles Hospital, Brisbane, Qld, Australia; 
      School of Allied Health Sciences, Griffith University, Gold Coast, Qld, 
      Australia.
FAU - Tronstad, Oystein
AU  - Tronstad O
AD  - Physiotherapy Department, The Prince Charles Hospital, Brisbane, Qld, Australia; 
      Intensive Care Unit, The Prince Charles Hospital, Brisbane, Qld, Australia; 
      Critical Care Research Group, University of Queensland, Brisbane, Qld, Australia.
FAU - Ziegenfuss, Marc D
AU  - Ziegenfuss MD
AD  - Intensive Care Unit, The Prince Charles Hospital, Brisbane, Qld, Australia.
FAU - Mullany, Dan V
AU  - Mullany DV
AD  - Intensive Care Unit, The Prince Charles Hospital, Brisbane, Qld, Australia; 
      Critical Care Research Group, University of Queensland, Brisbane, Qld, Australia.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20180705
PL  - Australia
TA  - Heart Lung Circ
JT  - Heart, lung & circulation
JID - 100963739
SB  - IM
CIN - Am J Respir Crit Care Med. 2020 Feb 1;201(3):366-368. PMID: 31816259
MH  - Adult
MH  - *Extracorporeal Membrane Oxygenation
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - *Intensive Care Units
MH  - Male
MH  - Middle Aged
MH  - *Patient Discharge
MH  - *Quality of Life
MH  - *Survivors
OTO - NOTNLM
OT  - ECMO
OT  - Outcomes
OT  - Quality of Life
OT  - Survival
EDAT- 2018/07/29 06:00
MHDA- 2019/11/28 06:00
CRDT- 2018/07/29 06:00
PHST- 2017/10/10 00:00 [received]
PHST- 2018/05/22 00:00 [revised]
PHST- 2018/06/21 00:00 [accepted]
PHST- 2018/07/29 06:00 [pubmed]
PHST- 2019/11/28 06:00 [medline]
PHST- 2018/07/29 06:00 [entrez]
AID - S1443-9506(18)31795-5 [pii]
AID - 10.1016/j.hlc.2018.06.1044 [doi]
PST - ppublish
SO  - Heart Lung Circ. 2019 Jul;28(7):1090-1098. doi: 10.1016/j.hlc.2018.06.1044. Epub 
      2018 Jul 5.