PMID- 30054588
OWN - NLM
STAT- MEDLINE
DCOM- 20191114
LR  - 20191114
IS  - 1476-5543 (Electronic)
IS  - 0743-8346 (Linking)
VI  - 38
IP  - 10
DP  - 2018 Oct
TI  - Prediction of long-term neurodevelopmental outcome in preterm infants using 
      trajectories of general movement assessments.
PG  - 1398-1406
LID - 10.1038/s41372-018-0173-0 [doi]
AB  - OBJECTIVE: To assess the predictive value of trajectories and individual 
      assessment of quality of general movements (AQGM) for identification of 
      neurodevelopmental impairment (NDI) at 18-24 months corrected age (CA) in infants 
      <30 weeks gestational age and/or birth weight <1500 g. METHODS: In this 
      retrospective cohort study, AQGM at 6 weeks and 3 months CA were scored and 
      categorized as normal (N) or abnormal (A). AQGM measures were compared with 
      degree of NDI and Bayley Scales of Infant Development, Third Edition (BSID-III) 
      composite motor and cognitive scores. 'Persistently abnormal' AQGM included both 
      mildly abnormal (MA) and definitely abnormal (DA) assessments. A "modified AQGM" 
      where MA assessments were considered normal variant/transient injury was used to 
      conduct post-hoc analysis. RESULTS: Across 244 cases, persistently abnormal AQGM 
      trajectory predicted the level of NDI (OR 2.5, 95% CI 1.2, 5.1) compared to AQGM 
      trajectory that normalized. However, using the "modified AQGM", persistently DA 
      trajectories were associated with significantly lower BSID-III composite motor 
      and cognitive scores (p < 0.001 and p = 0.039, respectively). CONCLUSION: 
      Categorizing MA assessments as transient injury increased the predictive value of 
      AQGM trajectories and significantly predicted lower cognitive and motor scores at 
      18-24 months CA.
FAU - van Dyk, Jessie
AU  - van Dyk J
AD  - Department of Newborn and Developmental Paediatrics, Sunnybrook Health Sciences 
      Centre, Toronto, Canada. Jessie.vandyk@sunnybrook.ca.
AD  - Dalla Lana School of Public Health, University of Toronto, Toronto, Canada. 
      Jessie.vandyk@sunnybrook.ca.
FAU - Church, Paige
AU  - Church P
AD  - Department of Newborn and Developmental Paediatrics, Sunnybrook Health Sciences 
      Centre, Toronto, Canada.
FAU - Dell, Sharon
AU  - Dell S
AD  - Dalla Lana School of Public Health, University of Toronto, Toronto, Canada.
AD  - Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, 
      Canada.
FAU - To, Teresa
AU  - To T
AD  - Dalla Lana School of Public Health, University of Toronto, Toronto, Canada.
AD  - Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, 
      Canada.
FAU - Luther, Maureen
AU  - Luther M
AD  - Department of Newborn and Developmental Paediatrics, Sunnybrook Health Sciences 
      Centre, Toronto, Canada.
FAU - Shah, Vibhuti
AU  - Shah V
AD  - Dalla Lana School of Public Health, University of Toronto, Toronto, Canada.
LA  - eng
GR  - 410002978/Physicians' Services Incorporated Foundation (PSI)/International
GR  - 410002978/Physicians' Services Incorporated Foundation (PSI)/International
GR  - 410002978/Physicians' Services Incorporated Foundation (PSI)/International
GR  - 410002978/Physicians' Services Incorporated Foundation (PSI)/International
GR  - 410002978/Physicians' Services Incorporated Foundation (PSI)/International
GR  - 410002978/Physicians' Services Incorporated Foundation (PSI)/International
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180727
PL  - United States
TA  - J Perinatol
JT  - Journal of perinatology : official journal of the California Perinatal 
      Association
JID - 8501884
SB  - IM
MH  - Cerebral Palsy/diagnosis
MH  - Child Development
MH  - Cognitive Dysfunction/diagnosis
MH  - Developmental Disabilities/*diagnosis
MH  - Female
MH  - Gestational Age
MH  - Humans
MH  - Infant
MH  - *Infant, Extremely Premature
MH  - Infant, Newborn
MH  - Logistic Models
MH  - Male
MH  - Motor Disorders/diagnosis
MH  - Movement
MH  - Neurologic Examination
MH  - Neuropsychological Tests
MH  - Predictive Value of Tests
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Sensation Disorders/diagnosis
MH  - Sensitivity and Specificity
MH  - Severity of Illness Index
EDAT- 2018/07/29 06:00
MHDA- 2019/11/15 06:00
CRDT- 2018/07/29 06:00
PHST- 2018/03/10 00:00 [received]
PHST- 2018/06/20 00:00 [accepted]
PHST- 2018/07/29 06:00 [pubmed]
PHST- 2019/11/15 06:00 [medline]
PHST- 2018/07/29 06:00 [entrez]
AID - 10.1038/s41372-018-0173-0 [pii]
AID - 10.1038/s41372-018-0173-0 [doi]
PST - ppublish
SO  - J Perinatol. 2018 Oct;38(10):1398-1406. doi: 10.1038/s41372-018-0173-0. Epub 2018 
      Jul 27.