PMID- 30056106
OWN - NLM
STAT- MEDLINE
DCOM- 20190311
LR  - 20220408
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 683
DP  - 2018 Sep 14
TI  - Improvement of symptoms in a rat model of depression through combined zinc and 
      folic acid administration via up-regulation of the Trk B and NMDA.
PG  - 196-201
LID - S0304-3940(18)30515-9 [pii]
LID - 10.1016/j.neulet.2018.07.036 [doi]
AB  - The aim of this study was to observe the influence of combined zinc and folic 
      acid administration on depression and to explore its mechanism of action. Male 
      Sprague Dawley rats were randomly divided into five groups: control, model, 
      paroxetine (P), zinc + folic acid (ZnY), and zinc + folic acid + paroxetine 
      (ZnYP) groups. Rat models of depression were established by chronic mild 
      unpredictable stress for three weeks. These rats were then treated with different 
      interventions for four weeks and the sucrose preference test was then performed 
      to observe changes in rats' behavior. An HPLC-electrochemical method was used to 
      detect the levels of 5-hydroxytryptamine (5-HT), dopamine (DA) and norepinephrine 
      (NE) in the frontal cortex. qRT-PCR was employed to detect the mRNA levels of 
      tyrosine kinase receptor B (Trk B) and N-methyl-D-aspartate acid (NMDA) in the 
      frontal cortex; Western blotting was used to detect the protein levels of brain 
      derived neurotrophic factor (BDNF) in the frontal cortex. The results showed that 
      compared with the model group, sucrose consumption, 5-HT, NE and DA levels were 
      significantly increased in the ZnY group (P < 0.05). Also the mRNA levels of Trk 
      B and NMDA were significantly increased in the ZnY group compared with the model 
      group (P < 0.001). No significant up-regulation of BDNF was observed in the ZnY 
      group. We conclude that combined administration of zinc and folic acid can 
      improve the symptoms of depression-model rats, and its mechanism is related to 
      increased levels of 5-HT, DA and NE in the brain, and to the up-regulation of Trk 
      B and NMDA.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Dou, Mei
AU  - Dou M
AD  - The Institute of Human Nutrition, Medical College of Qingdao University, Qingdao 
      Shandong 266021, China.
FAU - Gong, Anjing
AU  - Gong A
AD  - Department of Neurosurgery, Affiliated hospital of Qingdao University, Qingdao 
      Shandong 266003, China.
FAU - Liang, Hui
AU  - Liang H
AD  - The Institute of Human Nutrition, Medical College of Qingdao University, Qingdao 
      Shandong 266021, China.
FAU - Wang, Qiuzhen
AU  - Wang Q
AD  - The Institute of Human Nutrition, Medical College of Qingdao University, Qingdao 
      Shandong 266021, China.
FAU - Wu, Yanyan
AU  - Wu Y
AD  - The Institute of Human Nutrition, Medical College of Qingdao University, Qingdao 
      Shandong 266021, China.
FAU - Ma, Aiguo
AU  - Ma A
AD  - The Institute of Human Nutrition, Medical College of Qingdao University, Qingdao 
      Shandong 266021, China. Electronic address: magfood@126.com.
FAU - Han, Lei
AU  - Han L
AD  - Department of Nutrition, Affiliated hospital of Qingdao University, Qingdao 
      Shandong 266003, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180726
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 6384-92-5 (N-Methylaspartate)
RN  - 935E97BOY8 (Folic Acid)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
RN  - J41CSQ7QDS (Zinc)
SB  - IM
MH  - Animals
MH  - Brain/drug effects/metabolism
MH  - Depression/*drug therapy/*metabolism/psychology
MH  - Disease Models, Animal
MH  - Drug Therapy, Combination
MH  - Folic Acid/*administration & dosage
MH  - Male
MH  - N-Methylaspartate/*metabolism
MH  - Random Allocation
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor Protein-Tyrosine Kinases/*metabolism
MH  - Up-Regulation/drug effects/physiology
MH  - Zinc/*administration & dosage
OTO - NOTNLM
OT  - 5-hydroxytryptamine
OT  - Depression
OT  - Folic acid
OT  - N-methyl-D-aspartate acid
OT  - Tyrosine kinase receptor B
OT  - Zinc
EDAT- 2018/07/30 06:00
MHDA- 2019/03/12 06:00
CRDT- 2018/07/30 06:00
PHST- 2018/04/03 00:00 [received]
PHST- 2018/07/24 00:00 [revised]
PHST- 2018/07/25 00:00 [accepted]
PHST- 2018/07/30 06:00 [pubmed]
PHST- 2019/03/12 06:00 [medline]
PHST- 2018/07/30 06:00 [entrez]
AID - S0304-3940(18)30515-9 [pii]
AID - 10.1016/j.neulet.2018.07.036 [doi]
PST - ppublish
SO  - Neurosci Lett. 2018 Sep 14;683:196-201. doi: 10.1016/j.neulet.2018.07.036. Epub 
      2018 Jul 26.