PMID- 30056862
OWN - NLM
STAT- MEDLINE
DCOM- 20180920
LR  - 20180920
IS  - 1879-0631 (Electronic)
IS  - 0024-3205 (Linking)
VI  - 207
DP  - 2018 Aug 15
TI  - Antibiotic-induced dysbiosis effects on the murine gastrointestinal tract and 
      their systemic repercussions.
PG  - 480-491
LID - S0024-3205(18)30371-0 [pii]
LID - 10.1016/j.lfs.2018.06.030 [doi]
AB  - The gastrointestinal tract has become a focus of study recently. The crosstalk 
      between microbiota, especially bacteria, and the intestinal mucosa has to be 
      accurately balanced in order to maintain physiological homeostasis in the human 
      body. This dynamic interaction results in different levels of short-chain fatty 
      acids (SCFAs), IgA, and T cell lymphocyte subsets, which could lead the human 
      body towards health or disease. The disruption of this microbiome characterises 
      gut dysbiosis. Antibiotics are usually prescribed to fight against bacterial 
      infection. They can also modulate the human microbiome, since it acts directly 
      over organisational taxonomic units (OTUs) when taken orally. As a result, these 
      pharmaceuticals enable gut dysbiosis and its systemic effects due to microbiome 
      disturbance. Here, current data have been gathered from mice model experiments 
      and epidemiological studies in an antibiotic-centred perspective. The presented 
      data suggest the importance of translational studies in a murine model focusing 
      on GIT homeostasis with bacterial groups since any changes to the GIT-microbiota 
      have systemic repercussions in human health and disease.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Rosa, Caio Pupin
AU  - Rosa CP
AD  - Immunology and Microbiology Department, Universidade Federal de Alfenas, Minas 
      Gerais, Brazil.
FAU - Brancaglion, Gustavo Andrade
AU  - Brancaglion GA
AD  - Immunology and Microbiology Department, Universidade Federal de Alfenas, Minas 
      Gerais, Brazil.
FAU - Miyauchi-Tavares, Tatimara M
AU  - Miyauchi-Tavares TM
AD  - Universidade Jose do Rosario Vellano, Minas Gerais, Brazil.
FAU - Corsetti, Patricia Paiva
AU  - Corsetti PP
AD  - Universidade Jose do Rosario Vellano, Minas Gerais, Brazil.
FAU - de Almeida, Leonardo Augusto
AU  - de Almeida LA
AD  - Immunology and Microbiology Department, Universidade Federal de Alfenas, Minas 
      Gerais, Brazil. Electronic address: leonardo.almeida@unifal-mg.edu.br.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180704
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Cytokines)
RN  - 0 (Fatty Acids, Volatile)
SB  - IM
MH  - Animals
MH  - Anti-Bacterial Agents/*adverse effects
MH  - Cytokines/metabolism
MH  - Disease Models, Animal
MH  - Dysbiosis/*drug therapy
MH  - Fatty Acids, Volatile/chemistry
MH  - Gastrointestinal Microbiome/*drug effects
MH  - Gastrointestinal Tract/*drug effects/microbiology
MH  - Homeostasis
MH  - Humans
MH  - Inflammation
MH  - Mice
MH  - T-Lymphocyte Subsets
MH  - T-Lymphocytes/cytology
OTO - NOTNLM
OT  - Antibiotics
OT  - Extraintestinal effects
OT  - Gut dysbiosis
OT  - Microbiota
EDAT- 2018/07/31 06:00
MHDA- 2018/09/21 06:00
CRDT- 2018/07/31 06:00
PHST- 2018/02/25 00:00 [received]
PHST- 2018/06/20 00:00 [revised]
PHST- 2018/06/28 00:00 [accepted]
PHST- 2018/07/31 06:00 [entrez]
PHST- 2018/07/31 06:00 [pubmed]
PHST- 2018/09/21 06:00 [medline]
AID - S0024-3205(18)30371-0 [pii]
AID - 10.1016/j.lfs.2018.06.030 [doi]
PST - ppublish
SO  - Life Sci. 2018 Aug 15;207:480-491. doi: 10.1016/j.lfs.2018.06.030. Epub 2018 Jul 
      4.