PMID- 30056913
OWN - NLM
STAT- MEDLINE
DCOM- 20181026
LR  - 20181026
IS  - 1873-2623 (Electronic)
IS  - 0041-1345 (Linking)
VI  - 50
IP  - 6
DP  - 2018 Jul-Aug
TI  - Histopathological Relevance of Angiotensin II Type 1 Receptor in Renal Transplant 
      Biopsy.
PG  - 1847-1849
LID - S0041-1345(18)30325-7 [pii]
LID - 10.1016/j.transproceed.2018.02.137 [doi]
AB  - The occurrence of anti-angiotensin II type 1 receptor (AT1R) antibodies is 
      thought to be a risk factor for transplant injury, but the relationship of AT1R 
      to graft loss in renal transplantation has not been assessed. The aim of our 
      study was to evaluate the expression of AT1R and its relationship with graft loss 
      in patients who had a renal transplant biopsy for cause. METHODS: AT1R 
      immunoreactivity was analyzed in 170 renal transplant biopsies. 
      Immunohistochemical evaluation of AT1R expression was performed on 4 mum-thick 
      paraffin sections mounted on silanized slides. AT1R expression was analyzed in 
      5 compartments: 1. glomeruli, 2. renal blood vessels (small and intermediate 
      arteries), 3. peritubular capillaries, 4. tubular epithelium, and 5. interstitium 
      based on a 3-step scale. RESULTS: Initially we checked 170 consecutive samples of 
      biopsies for the immunoreactivity of the AT1R. The study finally included 118 
      renal transplant patients in 1-year observation after the biopsy. The renal 
      allograft biopsy was performed between 6 days and 24 years after transplantation 
      and the diagnosis was based on Banff criteria. We observed positive 
      immunostaining of AT1R in tubular epithelium in 26.3% (42/118) of patients. A 
      total of 7 patients had staining assessed as 2 and 35 as 1. One year post-biopsy 
      graft loss in the AT1R (+) patients was 35.7 % (15/42) compared to 14.5% (11/76) 
      in the AT1R (-) group (P = .008). CONCLUSIONS: The expression of AT1R in tubular 
      epithelium of the biopsy for cause was associated with significantly higher graft 
      loss. The relevance of AT1R should be considered for better transplant 
      immunological risk assessment.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Sas, A
AU  - Sas A
AD  - Department of Nephrology and Transplantation Medicine, Wroclaw Medical 
      University, Wroclaw, Poland.
FAU - Donizy, P
AU  - Donizy P
AD  - Department of Pathomorphology and Oncological Cytology, Wroclaw Medical 
      University, Wroclaw, Poland.
FAU - Koscielska-Kasprzak, K
AU  - Koscielska-Kasprzak K
AD  - Research laboratory, Wroclaw Medical University, Wroclaw, Poland.
FAU - Kaminska, D
AU  - Kaminska D
AD  - Department of Nephrology and Transplantation Medicine, Wroclaw Medical 
      University, Wroclaw, Poland.
FAU - Mazanowska, O
AU  - Mazanowska O
AD  - Faculty of Medicine and Dentistry, Department of Nephrology and Transplantation 
      Medicine, Wroclaw Medical University, Wroclaw, Poland.
FAU - Krajewska, M
AU  - Krajewska M
AD  - Department of Nephrology and Transplantation Medicine, Wroclaw Medical 
      University, Wroclaw, Poland.
FAU - Chudoba, P
AU  - Chudoba P
AD  - Department of General, Vascular and Transplant Surgery, Wroclaw Medical 
      University, Wroclaw, Poland.
FAU - Korta, K
AU  - Korta K
AD  - Department of General, Vascular and Transplant Surgery, Wroclaw Medical 
      University, Wroclaw, Poland.
FAU - Halon, A
AU  - Halon A
AD  - Department of Pathomorphology and Oncological Cytology, Wroclaw Medical 
      University, Wroclaw, Poland.
FAU - Klinger, M
AU  - Klinger M
AD  - Department of Nephrology and Transplantation Medicine, Wroclaw Medical 
      University, Wroclaw, Poland.
FAU - Banasik, M
AU  - Banasik M
AD  - Department of Nephrology and Transplantation Medicine, Wroclaw Medical 
      University, Wroclaw, Poland. Electronic address: m.banasik@interia.pl.
LA  - eng
PT  - Journal Article
DEP - 20180314
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
RN  - 0 (Receptor, Angiotensin, Type 1)
SB  - IM
MH  - Adult
MH  - Biopsy
MH  - Female
MH  - Graft Rejection/immunology/metabolism
MH  - Humans
MH  - Kidney/immunology/*metabolism/pathology
MH  - *Kidney Transplantation/adverse effects
MH  - Male
MH  - Middle Aged
MH  - Receptor, Angiotensin, Type 1/*biosynthesis/immunology
MH  - Risk Factors
MH  - Transplantation, Homologous
EDAT- 2018/07/31 06:00
MHDA- 2018/10/27 06:00
CRDT- 2018/07/31 06:00
PHST- 2017/12/30 00:00 [received]
PHST- 2018/02/19 00:00 [accepted]
PHST- 2018/07/31 06:00 [entrez]
PHST- 2018/07/31 06:00 [pubmed]
PHST- 2018/10/27 06:00 [medline]
AID - S0041-1345(18)30325-7 [pii]
AID - 10.1016/j.transproceed.2018.02.137 [doi]
PST - ppublish
SO  - Transplant Proc. 2018 Jul-Aug;50(6):1847-1849. doi: 
      10.1016/j.transproceed.2018.02.137. Epub 2018 Mar 14.