PMID- 30057920 OWN - NLM STAT- MEDLINE DCOM- 20181105 LR - 20181114 IS - 2314-7156 (Electronic) IS - 2314-8861 (Print) IS - 2314-7156 (Linking) VI - 2018 DP - 2018 TI - The Role of Dendritic Cells in the Differentiation of T Follicular Helper Cells. PG - 7281453 LID - 10.1155/2018/7281453 [doi] LID - 7281453 AB - T follicular helper cells (T(FH)) are a subset of recently discovered CD4(+) T cells. Their major function is to participate in the formation of germinal centres (GCs) and promote B cell proliferation and differentiation to play important roles in the production of antibodies. Currently, the functions of T(FH) cells are clear. However, the early differentiation of these cells is not clear. Dendritic cells (DCs) participate in the differentiation of T(FH) cells. Therefore, this article reviewed the research progress regarding the influence of DCs on the differentiation of T(FH) cells and their major underlying mechanisms. FAU - Zou, Xueyang AU - Zou X AD - Department of Immunology, College of Basic Medical Sciences, Jilin University, Changchun 130021, China. FAU - Sun, Guangyu AU - Sun G AD - Department of Immunology, College of Basic Medical Sciences, Jilin University, Changchun 130021, China. FAU - Huo, Feifei AU - Huo F AD - Department of Immunology, College of Basic Medical Sciences, Jilin University, Changchun 130021, China. FAU - Chang, Lu AU - Chang L AD - Department of Immunology, College of Basic Medical Sciences, Jilin University, Changchun 130021, China. FAU - Yang, Wei AU - Yang W AUID- ORCID: 0000-0002-1584-2521 AD - Department of Immunology, College of Basic Medical Sciences, Jilin University, Changchun 130021, China. LA - eng PT - Journal Article PT - Review DEP - 20180702 PL - Egypt TA - J Immunol Res JT - Journal of immunology research JID - 101627166 SB - IM MH - Animals MH - B-Lymphocytes/*physiology MH - Cell Differentiation MH - Dendritic Cells/*immunology MH - Germinal Center/*immunology MH - Humans MH - Lymphocyte Activation MH - T-Lymphocytes, Helper-Inducer/*physiology PMC - PMC6051062 EDAT- 2018/07/31 06:00 MHDA- 2018/11/06 06:00 PMCR- 2018/07/02 CRDT- 2018/07/31 06:00 PHST- 2018/03/04 00:00 [received] PHST- 2018/06/13 00:00 [accepted] PHST- 2018/07/31 06:00 [entrez] PHST- 2018/07/31 06:00 [pubmed] PHST- 2018/11/06 06:00 [medline] PHST- 2018/07/02 00:00 [pmc-release] AID - 10.1155/2018/7281453 [doi] PST - epublish SO - J Immunol Res. 2018 Jul 2;2018:7281453. doi: 10.1155/2018/7281453. eCollection 2018.