PMID- 30058429
OWN - NLM
STAT- MEDLINE
DCOM- 20200804
LR  - 20211204
IS  - 1814-1412 (Electronic)
IS  - 1562-2975 (Linking)
VI  - 20
IP  - 7
DP  - 2019 Sep
TI  - Chronic social defeat stress differentially regulates the expression of BDNF 
      transcripts and epigenetic modifying enzymes in susceptible and resilient mice.
PG  - 555-566
LID - 10.1080/15622975.2018.1500029 [doi]
AB  - Objectives: Although stress is considered a primary risk factor for 
      neuropsychiatric disorders, a majority of individuals are resilient to the 
      effects of stress exposure and successfully adapt to adverse life events, while 
      others, the so-called susceptible individuals, may have problems to properly 
      adapt to environmental changes. However, the mechanisms underlying these 
      different responses to stress exposure are poorly understood.Methods: Adult male 
      C57BL/6J mice were exposed to chronic social defeat stress protocol and levels of 
      brain derived neurotrophic factor (BDNF) transcripts and epigenetic modifying 
      enzymes were analysed by real-time PCR in the hippocampus (HPC) and prefrontal 
      cortex (PFC) of susceptible and resilient mice.Results: We found a selective 
      reduction of BDNF-6 transcript in the HPC and an increase of BDNF-4 transcript in 
      the PFC of susceptible mice. Moreover, susceptible mice showed a selective 
      reduction of the g9a mRNA levels in the HPC, while HDAC-5 and DNMT3a mRNA levels 
      were specifically reduced in the PFC.Conclusions: Overall, our results, showing a 
      different expression of BDNF transcripts and epigenetic modifying enzymes in 
      susceptible and resilient mice, suggest that stress resilience is not simply a 
      lack of activation of stress-related pathways, but is related to the activation 
      of additional different specific mechanisms.
FAU - Mallei, Alessandra
AU  - Mallei A
AUID- ORCID: 0000-0001-6955-4755
AD  - Laboratory of Neuropsychopharmacology and Functional Neurogenomics - Dipartimento 
      di Scienze Farmacologiche e Biomolecolari and Center of Excellence on 
      Neurodegenerative Diseases, University of Milano, Milano, Italy.
FAU - Ieraci, Alessandro
AU  - Ieraci A
AUID- ORCID: 0000-0001-6737-7695
AD  - Laboratory of Neuropsychopharmacology and Functional Neurogenomics - Dipartimento 
      di Scienze Farmacologiche e Biomolecolari and Center of Excellence on 
      Neurodegenerative Diseases, University of Milano, Milano, Italy.
FAU - Popoli, Maurizio
AU  - Popoli M
AUID- ORCID: 0000-0003-4670-8664
AD  - Laboratory of Neuropsychopharmacology and Functional Neurogenomics - Dipartimento 
      di Scienze Farmacologiche e Biomolecolari and Center of Excellence on 
      Neurodegenerative Diseases, University of Milano, Milano, Italy.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180919
PL  - England
TA  - World J Biol Psychiatry
JT  - The world journal of biological psychiatry : the official journal of the World 
      Federation of Societies of Biological Psychiatry
JID - 101120023
RN  - 0 (Bdnf protein, mouse)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Dnmt3a protein, mouse)
RN  - EC 2.1.1.37 (DNA (Cytosine-5-)-Methyltransferases)
RN  - EC 2.1.1.37 (DNA Methyltransferase 3A)
RN  - EC 3.5.1.98 (Hdac5 protein, mouse)
RN  - EC 3.5.1.98 (Histone Deacetylases)
SB  - IM
MH  - Adaptation, Psychological
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - DNA (Cytosine-5-)-Methyltransferases/genetics
MH  - DNA Methyltransferase 3A
MH  - Disease Susceptibility
MH  - Epigenesis, Genetic
MH  - Hippocampus/*enzymology
MH  - Histone Deacetylases/genetics
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Prefrontal Cortex/*enzymology
MH  - Stress, Psychological/*enzymology/genetics
OTO - NOTNLM
OT  - Stress
OT  - epigenetic
OT  - hippocampus
OT  - histone-modifying enzymes
OT  - prefrontal cortex
EDAT- 2018/07/31 06:00
MHDA- 2020/08/05 06:00
CRDT- 2018/07/31 06:00
PHST- 2018/07/31 06:00 [pubmed]
PHST- 2020/08/05 06:00 [medline]
PHST- 2018/07/31 06:00 [entrez]
AID - 10.1080/15622975.2018.1500029 [doi]
PST - ppublish
SO  - World J Biol Psychiatry. 2019 Sep;20(7):555-566. doi: 
      10.1080/15622975.2018.1500029. Epub 2018 Sep 19.