PMID- 30058562
OWN - NLM
STAT- MEDLINE
DCOM- 20190829
LR  - 20220408
IS  - 0973-3922 (Electronic)
IS  - 0378-6323 (Linking)
VI  - 85
IP  - 3
DP  - 2019 May-Jun
TI  - Predictors of disease severity in drug reaction with eosinophilia and systemic 
      symptoms.
PG  - 266-275
LID - 10.4103/ijdvl.IJDVL_482_17 [doi]
AB  - BACKGROUND: Drug reaction with eosinophilia and systemic symptoms is an outcome 
      of a complex interaction between specific drugs, certain herpesviruse types and 
      the immune system of the affected individual and is characterized by an 
      unpredictable course and recurrent flares even after withdrawal of the offending 
      drug and administration of systemic steroids. AIMS: To identify the predictors of 
      disease severity in drug reaction with eosinophilia and systemic symptoms. 
      METHODS: After obtaining ethical clearance from the institutional ethics 
      committee and a written informed consent from individual study participant, the 
      first hundred patients who required inpatient care in Government Medical College, 
      Kozhikode with drug reaction with eosinophilia and systemic symptoms from January 
      1(st) 2011 were included in this study aimed to identify the predictors of 
      disease severity in drug reaction with eosinophilia and systemic symptoms. 
      RESULTS: Male-to-female ratio of the study group was 0.8:1. The presence of 
      atypical cells in peripheral smear and advanced age were found to be predictors 
      of disease severity in drug reaction with eosinophilia and systemic symptoms, 
      whereas, sex, facial erythema and edema and absolute eosinophil count were found 
      not to be predictors of the same. LIMITATIONS: The main limitation of this study 
      was our inability to assess the role of human leukocyte antigen (HLA) association 
      and herpes virus reactivation in disease severity in drug reaction with 
      eosinophilia and systemic symptoms. This study was also not designed to evaluate 
      the response to treatment given and the mortality caused by drug reaction with 
      eosinophilia and systemic symptoms. CONCLUSIONS: Studies on the predictors of 
      severity in drug reaction with eosinophilia and systemic symptoms in different 
      population groups may enable us to identify the warning signs and help to 
      formulate the standard therapeutic guidelines.
FAU - Sasidharanpillai, Sarita
AU  - Sasidharanpillai S
AD  - Department of Dermatology and Venereology, Government Medical College, Kozhikode, 
      Kerala, India.
FAU - Chathoth, Anuradha Thalian
AU  - Chathoth AT
AD  - Health Services, Koyilandy Taluk Hospital, Kozhikode, Kerala, India, India.
FAU - Khader, Anza
AU  - Khader A
AD  - Department of Dermatology and Venereology, Government Medical College, Kozhikode, 
      Kerala, India.
FAU - Reena Mariyath, Olasseri K
AU  - Reena Mariyath OK
AD  - Department of Dermatology and Venereology, Government Medical College, Kozhikode, 
      Kerala, India.
FAU - Riyaz, Najeeba
AU  - Riyaz N
AD  - Department of Dermatology and Venereology, Government Medical College, Kozhikode, 
      Kerala, India.
FAU - Binitha, Manikoth Payyanadan
AU  - Binitha MP
AD  - Department of Dermatology and Venereology, Government Medical College, Kozhikode, 
      Kerala, India.
FAU - Muhammed, Kunnummal
AU  - Muhammed K
AD  - Department of Dermatology and Venereology, Government Medical College, Kozhikode, 
      Kerala, India.
FAU - George, Biju
AU  - George B
AD  - Department of Social and Preventive Medicine, Government Medical College, 
      Kozhikode, Kerala, India.
FAU - Santhosh, Parvathy
AU  - Santhosh P
AD  - Department of Dermatology and Venereology, Government Medical College, Kozhikode, 
      Kerala, India.
FAU - Roslind, Sangeetha
AU  - Roslind S
AD  - Department of Dermatology and Venereology, Government Medical College, Kozhikode, 
      Kerala, India.
FAU - Paul, Nina
AU  - Paul N
AD  - Department of Dermatology and Venereology, Government Medical College, Kozhikode, 
      Kerala, India.
FAU - Thomas, Mithun Harold
AU  - Thomas MH
AD  - General Medicine, Government Medical College, Kozhikode, Kerala, India.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Indian J Dermatol Venereol Leprol
JT  - Indian journal of dermatology, venereology and leprology
JID - 7701852
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Child
MH  - Child, Preschool
MH  - Cross-Sectional Studies
MH  - Drug Hypersensitivity Syndrome/*diagnosis/*epidemiology
MH  - Eosinophilia/*diagnosis/*epidemiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - *Severity of Illness Index
MH  - Young Adult
OTO - NOTNLM
OT  - Disease severity
OT  - drug reaction with eosinophilia and systemic symptoms
OT  - predictors
COIS- None
EDAT- 2018/07/31 06:00
MHDA- 2019/08/30 06:00
CRDT- 2018/07/31 06:00
PHST- 2018/07/31 06:00 [pubmed]
PHST- 2019/08/30 06:00 [medline]
PHST- 2018/07/31 06:00 [entrez]
AID - 237376 [pii]
AID - 10.4103/ijdvl.IJDVL_482_17 [doi]
PST - ppublish
SO  - Indian J Dermatol Venereol Leprol. 2019 May-Jun;85(3):266-275. doi: 
      10.4103/ijdvl.IJDVL_482_17.