PMID- 30058579
OWN - NLM
STAT- MEDLINE
DCOM- 20181217
LR  - 20220318
IS  - 2542-5641 (Electronic)
IS  - 0366-6999 (Print)
IS  - 0366-6999 (Linking)
VI  - 131
IP  - 15
DP  - 2018 Aug 5
TI  - Effectiveness of Glaucoma Diagnostic Parameters from Spectral Domain-Optical 
      Coherence Tomography of Myopic Patients.
PG  - 1819-1826
LID - 10.4103/0366-6999.237391 [doi]
AB  - BACKGROUND: Currently, spectral-domain optical coherence tomography (SD-OCT) 
      appears to be a new type of glaucoma diagnostic tool. Thus, this study aimed to 
      evaluate the effectiveness of glaucoma diagnostic parameters from SD-OCT of 
      patients with different severities of myopia. METHODS: This was a cross-sectional 
      study. A total of 248 participants (248 eyes) were enrolled, including 51 cases 
      in the early primary open-angle glaucoma group, 79 cases in the control group 
      (0.50 D to -0.50 D, excluding -0.50 D), 47 cases in the low-myopic group (-0.50 
      to -3.00 D, excluding -3.00 D), 43 cases in the moderate-myopic group (-3.00 to 
      -6.00 D, excluding -6.00 D), and 28 cases in the high-myopic group (</=-6.00 D). 
      All participants were examined using the Humphrey visual field test and SD-OCT. 
      The SD-OCT parameters of the retinal nerve fiber layer (RNFL) and ganglion cell 
      complex were analyzed statistically using the receiver operating characteristic 
      curve and area under the curve (AUC). RESULTS: The AUC showed that the best 
      parameters for the control and low-myopic groups were the inferior and inferior 
      temporal RNFL thicknesses (AUC >0.94), respectively; for the moderate- and 
      high-myopic groups, the best parameter was the temporal low RNFL thickness (AUC, 
      0.926 and 0.896, respectively). The AUC of the inferior parameters of the 
      moderate-myopic group (0.864) was lower, ranked 15(th) among all RNFL parameters. 
      When the sensitivity was fixed at 85%, the specificity of the inferior, superior, 
      inferior temporal, and superior temporal quadrants was higher (>80%) in the 
      control and low-myopic groups, while they were lower (20-60%) for the moderate- 
      and high-myopia groups. The green color based on the OCT database was also less 
      for the high-myopic group compared with that of other groups (P < 0.05). 
      CONCLUSIONS: Glaucoma diagnostic parameters from SD-OCT were not clinically 
      effective for the moderate- and high-myopic groups. The specificities were low. 
      The moderate- and high-myopic groups require comprehensive analyses for the 
      diagnoses of glaucoma. The SD-OCT database should be improved to better indicate 
      the level of myopia based on the corresponding diopter readings.
FAU - Fang, Yuan
AU  - Fang Y
AD  - Department of Ophthalmology, Peking University First Hospital, Beijing 100034, 
      China.
FAU - Zhang, Han-Qiao
AU  - Zhang HQ
AD  - Department of Ophthalmology, Beijing Tsinghua Changgung Hospital, Beijing 102218, 
      China.
FAU - Qiao, Rong-Hua
AU  - Qiao RH
AD  - Department of Ophthalmology, Beijing Tsinghua Changgung Hospital, Beijing 102218, 
      China.
FAU - Yao, Xu-Yang
AU  - Yao XY
AD  - Department of Ophthalmology, Peking University First Hospital, Beijing 100034, 
      China.
FAU - Pan, Ying-Zi
AU  - Pan YZ
AD  - Department of Ophthalmology, Peking University First Hospital, Beijing 100034, 
      China.
FAU - Li, Mei
AU  - Li M
AD  - Department of Ophthalmology, Peking University First Hospital, Beijing 100034, 
      China.
LA  - eng
PT  - Journal Article
PL  - China
TA  - Chin Med J (Engl)
JT  - Chinese medical journal
JID - 7513795
SB  - IM
MH  - Aged
MH  - Case-Control Studies
MH  - Cross-Sectional Studies
MH  - Female
MH  - Glaucoma/*diagnostic imaging
MH  - Glaucoma, Open-Angle
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nerve Fibers
MH  - Optic Disk
MH  - ROC Curve
MH  - Retinal Ganglion Cells
MH  - *Tomography, Optical Coherence
MH  - Visual Fields
PMC - PMC6071466
OTO - NOTNLM
OT  - Glaucoma
OT  - Myopia
OT  - Nerve Fibers
OT  - Open Angle
OT  - Retina
COIS- There are no conflicts of interest
EDAT- 2018/07/31 06:00
MHDA- 2018/12/18 06:00
PMCR- 2018/08/05
CRDT- 2018/07/31 06:00
PHST- 2018/07/31 06:00 [entrez]
PHST- 2018/07/31 06:00 [pubmed]
PHST- 2018/12/18 06:00 [medline]
PHST- 2018/08/05 00:00 [pmc-release]
AID - ChinMedJ_2018_131_15_1819_237391 [pii]
AID - CMJ-131-1819 [pii]
AID - 10.4103/0366-6999.237391 [doi]
PST - ppublish
SO  - Chin Med J (Engl). 2018 Aug 5;131(15):1819-1826. doi: 10.4103/0366-6999.237391.