PMID- 30058584
OWN - NLM
STAT- MEDLINE
DCOM- 20181217
LR  - 20220330
IS  - 2542-5641 (Electronic)
IS  - 0366-6999 (Print)
IS  - 0366-6999 (Linking)
VI  - 131
IP  - 15
DP  - 2018 Aug 5
TI  - Association of Estrogen Receptor 1 Genetic Polymorphisms with Recurrent 
      Spontaneous Abortion Risk.
PG  - 1857-1865
LID - 10.4103/0366-6999.237412 [doi]
AB  - BACKGROUND: Estrogen is one of the most important reproductive steroidal hormones 
      and plays a critical role in the maintenance of pregnancy, and its function is 
      mediated by estrogen receptor 1(ESR1). The polymorphisms of ESR1 were involved in 
      recurrent spontaneous abortion (RSA); however, the association between ESR1 
      polymorphisms and RSA remains controversial. The present meta-analysis was aimed 
      to clarify the association between ESR1 PvuII (-397C/T, rs2234693) and XbaI 
      (-351A/G, rs9340799) polymorphisms and the risk of RSA. METHODS: All the included 
      articles were retrieved from PubMed, Embase, Cochrane Library, China National 
      Knowledge Infrastructure, and Wanfang Med Online Database up to January 3, 2018. 
      Data were processed in the Stata 12.0 software. The odds ratios (OR s) and 95% 
      confidence intervals (95% CI s) were calculated using fixed-effects models 
      (FEM)/random-effects models (REM). RESULTS: Seven case-control studies with 836 
      cases and 1164 controls were included in the study. Generally, the ESR1 
      polymorphisms were not associated with RSA in any of the genetic analysis models. 
      However, it was found that as rs9340799 polymorphism was related to increased 
      risk of RSA in non-Asian group in the homozygous genetic model (OR = 2.40, 95% CI 
      = 1.05-5.50, P = 0.039). Moreover, in Asian group, rs9340799 polymorphism was 
      found to be related to decreased RSA risk in both the heterozygous model (OR = 
      0.53, 95% CI = 0.33-0.85, P = 0.009) and the dominant genetic model (OR = 0.55, 
      95% CI = 0.30-0.98, P = 0.042). CONCLUSIONS: Generally, there was no significant 
      association between the polymorphisms of ESR1 and the risk of RSA. However, 
      subgroup analysis indicated that ESR1 rs9340799 polymorphism was related to 
      increased RSA risk in the non-Asian group while associated with decreased RSA 
      risk in Asian group.
FAU - Yin, Xun-Qiang
AU  - Yin XQ
AD  - School of Medicine and Life Sciences, University of Jinan-Shandong Academy of 
      Medical Sciences; Laboratory for Molecular Immunology, Institute of Basic 
      Medicine, Shandong Academy of Medical Sciences, Jinan, Shandong 250062, China.
FAU - Ju, Hong-Mei
AU  - Ju HM
AD  - Department of Gynaecology, Affiliated Hospital of Shandong University of 
      Traditional Chinese Medicine, Jinan, Shandong 250011, China.
FAU - Guo, Qiang
AU  - Guo Q
AD  - Laboratory for Molecular Immunology, Institute of Basic Medicine, Shandong 
      Academy of Medical Sciences, Jinan, Shandong 250062, China.
FAU - Zhao, Lin
AU  - Zhao L
AD  - Laboratory for Molecular Immunology, Institute of Basic Medicine, Shandong 
      Academy of Medical Sciences, Jinan, Shandong 250062, China.
FAU - Zhu, Xiao-Xiao
AU  - Zhu XX
AD  - Laboratory for Molecular Immunology, Institute of Basic Medicine, Shandong 
      Academy of Medical Sciences, Jinan, Shandong 250062, China.
FAU - Wei, Ran
AU  - Wei R
AD  - Laboratory for Molecular Immunology, Institute of Basic Medicine, Shandong 
      Academy of Medical Sciences, Jinan, Shandong 250062, China.
FAU - Zhang, Zhen
AU  - Zhang Z
AD  - Laboratory for Molecular Immunology, Institute of Basic Medicine, Shandong 
      Academy of Medical Sciences, Jinan, Shandong 250062, China.
FAU - Zhang, Yun-Hong
AU  - Zhang YH
AD  - School of Medicine and Life Sciences, University of Jinan-Shandong Academy of 
      Medical Sciences; Laboratory for Molecular Immunology, Institute of Basic 
      Medicine, Shandong Academy of Medical Sciences, Jinan, Shandong 250062, China.
FAU - Wang, Bin
AU  - Wang B
AD  - Department of Peripheral Vascular Disease, Affiliated Hospital of Shandong 
      University of Traditional Chinese Medicine, Jinan, Shandong 250011, China.
FAU - Li, Xia
AU  - Li X
AD  - Laboratory for Molecular Immunology, Institute of Basic Medicine, Shandong 
      Academy of Medical Sciences, Jinan, Shandong 250062, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PL  - China
TA  - Chin Med J (Engl)
JT  - Chinese medical journal
JID - 7513795
RN  - 0 (ESR1 protein, human)
RN  - 0 (Estrogen Receptor alpha)
SB  - IM
MH  - Abortion, Spontaneous/*genetics
MH  - Case-Control Studies
MH  - China
MH  - Cohort Studies
MH  - Estrogen Receptor alpha/*genetics
MH  - Female
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Iran
MH  - Polymorphism, Genetic
MH  - Polymorphism, Single Nucleotide
MH  - Pregnancy
MH  - Risk Factors
PMC - PMC6071461
OTO - NOTNLM
OT  - Estrogen Receptor 1
OT  - Meta-Analysis
OT  - Polymorphism
OT  - Recurrent Spontaneous Abortion
OT  - Risk
COIS- There are no conflicts of interest
EDAT- 2018/07/31 06:00
MHDA- 2018/12/18 06:00
PMCR- 2018/08/05
CRDT- 2018/07/31 06:00
PHST- 2018/07/31 06:00 [entrez]
PHST- 2018/07/31 06:00 [pubmed]
PHST- 2018/12/18 06:00 [medline]
PHST- 2018/08/05 00:00 [pmc-release]
AID - ChinMedJ_2018_131_15_1857_237412 [pii]
AID - CMJ-131-1857 [pii]
AID - 10.4103/0366-6999.237412 [doi]
PST - ppublish
SO  - Chin Med J (Engl). 2018 Aug 5;131(15):1857-1865. doi: 10.4103/0366-6999.237412.