PMID- 30059659
OWN - NLM
STAT- MEDLINE
DCOM- 20190212
LR  - 20190215
IS  - 1873-3492 (Electronic)
IS  - 0009-8981 (Linking)
VI  - 486
DP  - 2018 Nov
TI  - Blood concentrations of lipopolysaccharide-binding protein, high-sensitivity 
      C-reactive protein, tumor necrosis factor-alpha, and Interleukin-6 in relation to 
      insulin resistance in young adolescents.
PG  - 115-121
LID - S0009-8981(18)30389-9 [pii]
LID - 10.1016/j.cca.2018.07.042 [doi]
AB  - BACKGROUND: We assessed the association of insulin resistance as indicated by the 
      homeostatic model assessment of insulin resistance (HOMA-IR) with inflammatory 
      molecules, lipopolysaccharide-binding protein (LBP), high sensitivity C-reactive 
      protein (hs-CRP), Tumor necrosis factor-alpha (TNF-alpha), and Interleukin-6 (IL-6) in 
      urban young adolescents. METHODS: Seventy-six adolescents (36 subjects with 
      HOMA-IR >/= 2.6 and 40 subjects with HOMA-IR < 2.6) were included in the study. We 
      assessed anthropometric and laboratory measures, such as BMI, blood pressure, 
      insulin sensitivity, liver enzymes, and lipid profiles along with the 
      aforementioned inflammatory biomarkers. The diagnostic accuracy of LBP, hs-CRP, 
      TNF-alpha, and IL-6 for insulin resistance was evaluated by using the receiver 
      operating characteristic (ROC) curve analysis. RESULTS: The mean age of the study 
      subjects was 12.0 [12.0-13.0] y. Circulating LBP plasma concentration and hs-CRP 
      were significantly increased in subjects with HOMA-IR >/= 2.6 when compared with 
      those with HOMA-IR < 2.6 (P < .0001). There was no difference in TNF-alpha or IL-6 
      concentrations between groups. Comparisons based on the area under the ROC curve 
      for LBP, hs-CRP, TNF-alpha, and IL-6 with regard to insulin resistance 
      (HOMA-IR >/= 2.6) were 0.8384 (95% CI: 0.7380 to 0.9388), 0.7907 (95% CI: 0.6701 to 
      0.9113), 0.6207 (95% CI: 0.4770 to 0.7643), and 0.5763 (95% CI: 0.4285 to 
      0.7241), respectively. CONCLUSIONS: Among LBP, hs-CRP, TNF-alpha, and IL-6, plasma 
      LBP has the greatest diagnostic accuracy for insulin resistance in young 
      adolescents. Prospective studies are warranted to delineate the value of LBP in 
      the prediction of insulin resistance.
CI  - Copyright (c) 2018. Published by Elsevier B.V.
FAU - Kim, Ki Eun
AU  - Kim KE
AD  - Department of Pediatrics, CHA Gangnam Medical Center, CHA University School of 
      Medicine, Seoul, Republic of Korea.
FAU - Heo, Ju Sun
AU  - Heo JS
AD  - Department of Pediatrics, Korea University Anam Hospital, Seoul, Republic of 
      Korea.
FAU - Han, Sol
AU  - Han S
AD  - Department of Pediatrics, CHA Gangnam Medical Center, CHA University School of 
      Medicine, Seoul, Republic of Korea.
FAU - Kwon, Seul-Ki
AU  - Kwon SK
AD  - Department of Biomedical Science, CHA University, CHA Bundang Medical Center, 
      Seongnam, Republic of Korea.
FAU - Kim, Soo-Yeon
AU  - Kim SY
AD  - Department of Biomedical Science, CHA University, CHA Bundang Medical Center, 
      Seongnam, Republic of Korea.
FAU - Kim, Jung Hyun
AU  - Kim JH
AD  - Atmin Radiology and Health Promotion Center, Seoul, Republic of Korea.
FAU - Baek, Kwang-Hyun
AU  - Baek KH
AD  - Department of Biomedical Science, CHA University, CHA Bundang Medical Center, 
      Seongnam, Republic of Korea.
FAU - Sheen, Youn Ho
AU  - Sheen YH
AD  - Department of Pediatrics, CHA Gangnam Medical Center, CHA University School of 
      Medicine, Seoul, Republic of Korea. Electronic address: epirubicin13@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20180729
PL  - Netherlands
TA  - Clin Chim Acta
JT  - Clinica chimica acta; international journal of clinical chemistry
JID - 1302422
RN  - 0 (Acute-Phase Proteins)
RN  - 0 (Biomarkers)
RN  - 0 (Carrier Proteins)
RN  - 0 (Interleukin-6)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (lipopolysaccharide-binding protein)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Acute-Phase Proteins
MH  - Adolescent
MH  - Biomarkers/blood
MH  - C-Reactive Protein/*analysis
MH  - Carrier Proteins/*blood
MH  - Child
MH  - Female
MH  - Humans
MH  - *Insulin Resistance
MH  - Interleukin-6/*blood
MH  - Male
MH  - Membrane Glycoproteins/*blood
MH  - ROC Curve
MH  - Tumor Necrosis Factor-alpha/*blood
OTO - NOTNLM
OT  - Adolescent
OT  - Body mass index
OT  - Inflammation
OT  - Insulin resistance
OT  - Lipopolysaccharide-binding protein
OT  - Obesity
EDAT- 2018/07/31 06:00
MHDA- 2019/02/13 06:00
CRDT- 2018/07/31 06:00
PHST- 2018/05/26 00:00 [received]
PHST- 2018/07/26 00:00 [revised]
PHST- 2018/07/26 00:00 [accepted]
PHST- 2018/07/31 06:00 [pubmed]
PHST- 2019/02/13 06:00 [medline]
PHST- 2018/07/31 06:00 [entrez]
AID - S0009-8981(18)30389-9 [pii]
AID - 10.1016/j.cca.2018.07.042 [doi]
PST - ppublish
SO  - Clin Chim Acta. 2018 Nov;486:115-121. doi: 10.1016/j.cca.2018.07.042. Epub 2018 
      Jul 29.