PMID- 30059991
OWN - NLM
STAT- MEDLINE
DCOM- 20190325
LR  - 20190325
IS  - 1945-7170 (Electronic)
IS  - 0013-7227 (Linking)
VI  - 159
IP  - 10
DP  - 2018 Oct 1
TI  - Association of In Utero Persistent Organic Pollutant Exposure With Placental 
      Thyroid Hormones.
PG  - 3473-3481
LID - 10.1210/en.2018-00542 [doi]
AB  - In utero exposure to persistent organic pollutants (POPs) can result in thyroid 
      function disorder, leading to concerns about their impact on fetal and neonatal 
      development. The associations between placental levels of various POPs and 
      thyroid hormones (THs) were investigated. In a prospective Danish study initially 
      established for assessing congenital cryptorchidism, 58 placenta samples were 
      collected from mothers of boys born with (n = 28) and without (n = 30) 
      cryptorchidism. The concentrations of polybrominated diphenyl ethers (PBDEs), 
      polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins/furans 
      (PCDD/Fs), organotin chemicals (OTCs), organochlorine pesticides (OCPs), T4, T3, 
      and rT3 were measured. The associations between placental THs and various POPs 
      were analyzed using multiple linear regression. Five PBDEs, 35 PCBs, 14 PCDD/Fs, 
      3 OTCs, 25 OCPs, T4, T3, and rT3 were measured. No correlation between THs and 
      the odds of cryptorchidism was found. Several POPs were significantly associated 
      with THs: (1) T4 was inversely associated with BDEs 99, 100, SigmaPBDE, and 
      2378-TeCDD, and positively associated with 1234678-HpCDF; (2) T3 was positively 
      associated with 2378-TeCDF and 12378-PeCDF; and (3) rT3 was positively associated 
      with PCB 81, 12378-PeCDF, and 234678-HxCDF, and inversely associated with 
      tributyltin, SigmaOTC, and methoxychlor. These results revealed that POP exposures 
      were associated with TH levels in placenta, which may be a possible mechanism for 
      the impacts of POP exposures on children's growth and development. This study 
      provides new insight into the complexity of thyroid-disrupting properties of 
      POPs. More research is needed to elucidate the biological consequences of POP 
      exposures.
FAU - Li, Zhong-Min
AU  - Li ZM
AD  - Helmholtz Zentrum Munchen-German Research Center for Environmental Health, 
      Molecular EXposomics, Neuherberg, Germany.
AD  - School of Life Sciences Weihenstephan (Nutrition), Technische Universitat 
      Munchen, Freising, Germany.
FAU - Hernandez-Moreno, David
AU  - Hernandez-Moreno D
AD  - Helmholtz Zentrum Munchen-German Research Center for Environmental Health, 
      Molecular EXposomics, Neuherberg, Germany.
FAU - Main, Katharina Maria
AU  - Main KM
AD  - Department of Growth and Reproduction, EDMaRC, Rigshospitalet, University of 
      Copenhagen, Copenhagen, Denmark.
FAU - Skakkebaek, Niels Erik
AU  - Skakkebaek NE
AD  - Department of Growth and Reproduction, EDMaRC, Rigshospitalet, University of 
      Copenhagen, Copenhagen, Denmark.
FAU - Kiviranta, Hannu
AU  - Kiviranta H
AD  - National Institute for Health and Welfare, Department of Health Security, Kuopio, 
      Finland.
FAU - Toppari, Jorma
AU  - Toppari J
AD  - Department of Growth and Reproduction, EDMaRC, Rigshospitalet, University of 
      Copenhagen, Copenhagen, Denmark.
AD  - Institute of Biomedicine, University of Turku, Turku, Finland.
AD  - Department of Pediatrics, Turku University Hospital, Turku, Finland.
FAU - Feldt-Rasmussen, Ulla
AU  - Feldt-Rasmussen U
AD  - Department of Medical Endocrinology PE, Rigshospitalet, University of Copenhagen, 
      Copenhagen, Denmark.
FAU - Shen, Heqing
AU  - Shen H
AD  - Key Laboratory of Urban Environment and Health, Institute of Urban Environment, 
      Chinese Academy of Sciences, Xiamen, China.
FAU - Schramm, Karl-Werner
AU  - Schramm KW
AD  - Helmholtz Zentrum Munchen-German Research Center for Environmental Health, 
      Molecular EXposomics, Neuherberg, Germany.
AD  - Department fur Biowissenschaftliche Grundlagen, Technische Universitat Munchen, 
      Freising, Germany.
FAU - De Angelis, Meri
AU  - De Angelis M
AD  - Helmholtz Zentrum Munchen-German Research Center for Environmental Health, 
      Molecular EXposomics, Neuherberg, Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Endocrinology
JT  - Endocrinology
JID - 0375040
RN  - 0 (2,2',4,4',5-brominated diphenyl ether)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (Pesticides)
RN  - 0 (Thyroid Hormones)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Child
MH  - Cryptorchidism/diagnosis/etiology
MH  - Environmental Pollutants/*poisoning
MH  - Female
MH  - Halogenated Diphenyl Ethers/poisoning
MH  - Humans
MH  - Male
MH  - Maternal Exposure/*adverse effects
MH  - Pesticides/poisoning
MH  - Placenta/*drug effects/metabolism
MH  - Polychlorinated Biphenyls/poisoning
MH  - Pregnancy
MH  - Prospective Studies
MH  - Thyroid Hormones/*metabolism
EDAT- 2018/07/31 06:00
MHDA- 2019/03/26 06:00
CRDT- 2018/07/31 06:00
PHST- 2018/06/04 00:00 [received]
PHST- 2018/07/19 00:00 [accepted]
PHST- 2018/07/31 06:00 [pubmed]
PHST- 2019/03/26 06:00 [medline]
PHST- 2018/07/31 06:00 [entrez]
AID - 5060453 [pii]
AID - 10.1210/en.2018-00542 [doi]
PST - ppublish
SO  - Endocrinology. 2018 Oct 1;159(10):3473-3481. doi: 10.1210/en.2018-00542.