PMID- 30061941
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1792-1074 (Print)
IS  - 1792-1082 (Electronic)
IS  - 1792-1074 (Linking)
VI  - 16
IP  - 1
DP  - 2018 Jul
TI  - Dendritic cells loaded with the lysate of tumor cells infected with Newcastle 
      Disease Virus trigger potent anti-tumor immunity by promoting the secretion of 
      IFN-gamma and IL-2 from T cells.
PG  - 1180-1188
LID - 10.3892/ol.2018.8785 [doi]
AB  - Dendritic cells (DCs) are professional antigen-presenting cells that are pivotal 
      in the generation and sustainability of antitumor immune responses. Whole tumor 
      cell lysates (TCLs) have been used as sources of tumor antigens for the 
      development of DC vaccines. However, the clinical outcomes of the use of 
      TCL-based DC vaccines have so far been unsatisfactory because of the weak 
      immunogenicity of tumor cells. To improve the efficacy of TCL-based DC vaccines, 
      viruses have been used to enhance the immunity of TCLs and to further enhance the 
      antigen delivery and antigen-presenting ability of DCs. The aim of the present 
      study was to improve the antigen-presenting ability of DCs and to use them to 
      effectively activate T lymphocytes. The present study demonstrated that DCs 
      loaded with the lysate of Newcastle Disease Virus (NDV)-infected tumor cells 
      (NDV-TCL) have increased levels of cluster of differentiation 80 (CD80), CD86, 
      CD83 and human leukocyte antigen-antigen D-associated expression, compared with 
      those loaded with TCL alone. The DCs loaded with the NDV-TCL promoted T-cell 
      proliferation and antitumor cytokine secretion from T cells. These results 
      indicated that loading DCs with NDV-TCL could enhance the antigen-presenting 
      ability of the DCs. On the basis of the results of the present study, we 
      hypothesize that this method of loading DCs with NDV-TCL can be used to develop 
      novel DC vaccines for tumor immunotherapy in the future.
FAU - Zhao, Lianjing
AU  - Zhao L
AD  - Cancer Center, The First Hospital of Jilin University, Changchun, Jilin 130021, 
      P.R. China.
AD  - State Key Laboratory on Integrated Optoelectronics, College of Electronic Science 
      and Engineering, Jilin University, Changchun, Jilin 130012, P.R. China.
FAU - Niu, Chao
AU  - Niu C
AD  - Cancer Center, The First Hospital of Jilin University, Changchun, Jilin 130021, 
      P.R. China.
FAU - Shi, Xiumin
AU  - Shi X
AD  - Cancer Center, The First Hospital of Jilin University, Changchun, Jilin 130021, 
      P.R. China.
FAU - Xu, Dongsheng
AU  - Xu D
AD  - Cancer Center, The First Hospital of Jilin University, Changchun, Jilin 130021, 
      P.R. China.
FAU - Li, Min
AU  - Li M
AD  - Cancer Center, The First Hospital of Jilin University, Changchun, Jilin 130021, 
      P.R. China.
FAU - Cui, Jiuwei
AU  - Cui J
AD  - Cancer Center, The First Hospital of Jilin University, Changchun, Jilin 130021, 
      P.R. China.
FAU - Li, Wei
AU  - Li W
AD  - Cancer Center, The First Hospital of Jilin University, Changchun, Jilin 130021, 
      P.R. China.
FAU - Xu, Jianting
AU  - Xu J
AD  - Cancer Center, The First Hospital of Jilin University, Changchun, Jilin 130021, 
      P.R. China.
FAU - Jin, Haofan
AU  - Jin H
AD  - Cancer Center, The First Hospital of Jilin University, Changchun, Jilin 130021, 
      P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20180522
PL  - Greece
TA  - Oncol Lett
JT  - Oncology letters
JID - 101531236
PMC - PMC6063031
OTO - NOTNLM
OT  - T-cell activation
OT  - antitumor immunity
OT  - dendritic cell vaccine
OT  - newcastle disease virus
OT  - tumor cell lysate
EDAT- 2018/08/01 06:00
MHDA- 2018/08/01 06:01
PMCR- 2018/05/22
CRDT- 2018/08/01 06:00
PHST- 2016/12/28 00:00 [received]
PHST- 2017/12/04 00:00 [accepted]
PHST- 2018/08/01 06:00 [entrez]
PHST- 2018/08/01 06:00 [pubmed]
PHST- 2018/08/01 06:01 [medline]
PHST- 2018/05/22 00:00 [pmc-release]
AID - OL-0-0-8785 [pii]
AID - 10.3892/ol.2018.8785 [doi]
PST - ppublish
SO  - Oncol Lett. 2018 Jul;16(1):1180-1188. doi: 10.3892/ol.2018.8785. Epub 2018 May 
      22.