PMID- 30063009
OWN - NLM
STAT- MEDLINE
DCOM- 20190102
LR  - 20200130
IS  - 2410-8650 (Electronic)
IS  - 1607-551X (Linking)
VI  - 34
IP  - 7
DP  - 2018 Jul
TI  - IGF-1 defends against chronic-stress induced depression in rat models of chronic 
      unpredictable mild stress through the PI3K/Akt/FoxO3a pathway.
PG  - 370-376
LID - S1607-551X(17)30771-4 [pii]
LID - 10.1016/j.kjms.2018.02.004 [doi]
AB  - This study aims to investigate the role of IGF-1 in chronic-stress induced 
      depression through the PI3K/Akt/FoxO3a pathway. A rat model of chronic 
      unpredictable mild stress (CUMS) was established. In total, 48 rats were 
      randomized into control (normal rats), CUMS (CUMS modeled rats) and CUMS + IGF-1 
      (injection of IGF-1 before CUMS modeling) groups. Body weight, horizontal (number 
      of horizontal crossing) and vertical activity (rearing times), and sucrose 
      consumption were identified one day before and after the open-field test. The 
      mRNA and protein expression of PI3K, Akt, FoxO3a and Bim in the hippocampus was 
      measured by RT-qPCR and Western blotting, respectively. Compared with the control 
      group, a lower body weight, a decreased number of horizontal crossings, reduced 
      rearing times and lower sucrose consumption were observed in the CUMS and 
      CUMS + IGF-1 groups after the test. However, a higher body weight, number of 
      horizontal crossings, rearing times and sucrose consumption were found in the 
      CUMS + IGF-1 group than those in the CUMS group. Compared with the control group, 
      mRNA and protein expression of PI3K, Akt and FoxO3a was decreased, and Bim mRNA 
      and protein expression was increased in the CUMS + IGF-1 and CUMS groups. 
      Meanwhile, in comparison to the CUMS group, mRNA and protein expression of PI3K, 
      Akt and FoxO3a was elevated, and Bim mRNA and protein expression was reduced in 
      the CUMS + IGF-1 group. The results suggested that IGF-1 exerted an 
      antidepressant-like effect on chronic-stress induced depression through the 
      PI3K/Akt/FoxO3a pathway.
CI  - Copyright (c) 2018. Published by Elsevier Taiwan LLC.
FAU - Kuang, Wei-Hong
AU  - Kuang WH
AD  - Department of Psychiatry and Mental Health Center, West China Hospital, Sichuan 
      University, Chengdu, PR China.
FAU - Dong, Zai-Quan
AU  - Dong ZQ
AD  - Department of Psychiatry and Mental Health Center, West China Hospital, Sichuan 
      University, Chengdu, PR China.
FAU - Tian, Lian-Tian
AU  - Tian LT
AD  - Research Centre for Public Health and Preventive Medicine, West China School of 
      Public Health, No. 4 West China Teaching Hospital, Sichuan University, Chengdu, 
      PR China.
FAU - Li, Jin
AU  - Li J
AD  - Department of Psychiatry and Mental Health Center, West China Hospital, Sichuan 
      University, Chengdu, PR China. Electronic address: kwhhknx@163.com.
LA  - eng
PT  - Journal Article
DEP - 20180306
PL  - China (Republic : 1949- )
TA  - Kaohsiung J Med Sci
JT  - The Kaohsiung journal of medical sciences
JID - 100960562
RN  - 0 (Antidepressive Agents)
RN  - 0 (FOXO3 protein, rat)
RN  - 0 (Forkhead Box Protein O3)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/therapeutic use
MH  - Behavior, Animal/drug effects
MH  - Depression/*drug therapy/etiology/*metabolism
MH  - Disease Models, Animal
MH  - Forkhead Box Protein O3/*metabolism
MH  - Insulin-Like Growth Factor I/*therapeutic use
MH  - Male
MH  - Phosphatidylinositol 3-Kinases/*metabolism
MH  - Proto-Oncogene Proteins c-akt/*metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Stress, Psychological/*complications
OTO - NOTNLM
OT  - Chronic unpredictable mild stress
OT  - Chronic-stress induced depression
OT  - IGF-1
OT  - PI3K/Akt/FoxO3a signaling pathway
OT  - Rat models
EDAT- 2018/08/01 06:00
MHDA- 2019/01/03 06:00
CRDT- 2018/08/01 06:00
PHST- 2017/10/25 00:00 [received]
PHST- 2017/12/21 00:00 [revised]
PHST- 2018/02/06 00:00 [accepted]
PHST- 2018/08/01 06:00 [entrez]
PHST- 2018/08/01 06:00 [pubmed]
PHST- 2019/01/03 06:00 [medline]
AID - S1607-551X(17)30771-4 [pii]
AID - 10.1016/j.kjms.2018.02.004 [doi]
PST - ppublish
SO  - Kaohsiung J Med Sci. 2018 Jul;34(7):370-376. doi: 10.1016/j.kjms.2018.02.004. 
      Epub 2018 Mar 6.