PMID- 30063409 OWN - NLM STAT- MEDLINE DCOM- 20191030 LR - 20191030 IS - 1744-8417 (Electronic) IS - 1744-6651 (Linking) VI - 14 IP - 1 DP - 2019 Jan TI - Gestational diabetes risk factors and long-term consequences for both mother and offspring: a literature review. PG - 63-74 LID - 10.1080/17446651.2018.1476135 [doi] AB - INTRODUCTION: Established risk factors for gestational diabetes mellitus (GDM) include ethnicity, obesity, and family history of diabetes. Untreated GDM patients have higher rates of maternal and perinatal morbidity. GDM is an independent risk factor for future longer-term risk of type 2 diabetes mellitus (T2DM), metabolic syndrome, cardiovascular morbidity, malignancies, ophthalmic, psychiatric, and renal disease in the mother. Offspring risk long-term adverse health outcomes, including T2DM, subsequent obesity, impacted neurodevelopmental outcome, increased neuropsychiatric morbidity, and ophthalmic disease. AREAS COVERED: We critically review data from retrospective, prospective, and meta-analysis studies pertaining to established GDM risk factors, complications during pregnancy and birth (both mother and offspring), and long-term consequences (both mother and offspring). EXPERT COMMENTARY: Many of the adverse consequences of GDM might be avoided with proper management and treatment. Patients belonging to high-risk ethnic groups, and/or with body mass index >/= 25 kg/m(2), and/or known history of diabetes in first-degree relatives may benefit from universal screening and diagnostic criteria proposed by the International Association of Diabetes and Pregnancy Study Group (IADPSG). The IADPSG one-step method has several advantages, including simplicity of execution, greater patient-friendliness, and higher diagnostic accuracy. Additionally, evidence suggests that the recent increased popularity of bariatric surgery will help to decrease GDM rates over next 5 years. Similarly, metformin may be useful for treating and preventing obstetrical complications in confirmed GDM patients. FAU - Farahvar, Salar AU - Farahvar S AD - a Department of Obstetrics and Gynecology, Faculty of Health, Sciences, Soroka University Medical Center, Ben-Gurion , University of the Negev , Beer Sheva , Israel. FAU - Walfisch, Asnat AU - Walfisch A AUID- ORCID: 0000-0002-0201-9691 AD - a Department of Obstetrics and Gynecology, Faculty of Health, Sciences, Soroka University Medical Center, Ben-Gurion , University of the Negev , Beer Sheva , Israel. FAU - Sheiner, Eyal AU - Sheiner E AUID- ORCID: 0000-0002-0454-6874 AD - a Department of Obstetrics and Gynecology, Faculty of Health, Sciences, Soroka University Medical Center, Ben-Gurion , University of the Negev , Beer Sheva , Israel. LA - eng PT - Journal Article PT - Review DEP - 20180605 PL - England TA - Expert Rev Endocrinol Metab JT - Expert review of endocrinology & metabolism JID - 101278293 RN - 9100L32L2N (Metformin) SB - IM MH - Bariatric Surgery MH - Body Mass Index MH - Diabetes, Gestational/ethnology/*etiology/therapy MH - Disease Management MH - Evidence-Based Medicine MH - Female MH - Humans MH - Meta-Analysis as Topic MH - Metformin/therapeutic use MH - Pregnancy MH - Prospective Studies MH - Retrospective Studies MH - Risk Assessment/*ethnology/*methods OTO - NOTNLM OT - Gestational diabetes mellitus OT - bariatric surgery OT - maternal complications OT - metformin OT - offspring complications OT - risk factors OT - screening EDAT- 2018/08/01 06:00 MHDA- 2019/10/31 06:00 CRDT- 2018/08/01 06:00 PHST- 2018/08/01 06:00 [pubmed] PHST- 2019/10/31 06:00 [medline] PHST- 2018/08/01 06:00 [entrez] AID - 10.1080/17446651.2018.1476135 [doi] PST - ppublish SO - Expert Rev Endocrinol Metab. 2019 Jan;14(1):63-74. doi: 10.1080/17446651.2018.1476135. Epub 2018 Jun 5.