PMID- 30063660
OWN - NLM
STAT- MEDLINE
DCOM- 20191011
LR  - 20191011
IS  - 1538-9235 (Electronic)
IS  - 1040-5488 (Linking)
VI  - 95
IP  - 8
DP  - 2018 Aug
TI  - Effects of Measurement Center Shift on Ganglion Cell-inner Plexiform Layer 
      Thickness Measurements.
PG  - 656-662
LID - 10.1097/OPX.0000000000001251 [doi]
AB  - SIGNIFICANCE: Our authors studied the effects of measurement center shift on 
      ganglion cell-inner plexiform layer (GCIPL) thickness measurements in Cirrus 
      spectral-domain optical coherence tomography (SD-OCT). The measurement center 
      shift affects the GCIPL thickness measurement depending on the distance of shift. 
      PURPOSE: The purpose of this study was to explore changes in macular GCIPL 
      thicknesses measurements after manual shifting of the measurement center using 
      SD-OCT. METHODS: A prospective study was conducted. A total of 30 normal eyes of 
      30 subjects were included in the study. An experienced examiner obtained two 
      consecutive measurements of GCIPL thickness using SD-OCT. Coefficients of 
      repeatability were calculated for the average, minimum, and sectoral 
      (superotemporal, superior, superonasal, inferonasal, inferior, and 
      inferotemporal) thicknesses. Next, the measurement center was manually shifted 
      from the foveal center. Three measurement centers were horizontally placed at 
      59-mum intervals from the foveal center, and two further centers were placed 176 
      mum apart. Also, three measurement centers were vertically placed at 47-mum 
      intervals from the foveal center, and two further centers were placed 142 mum 
      apart. The thickness of GCIPL was measured again at each shift point, and the 
      changes of thickness before and after movement were analyzed. RESULTS: When the 
      measurement centers were shifted to positions 59 mum horizontally or 47 mum 
      vertically from the fovea, no significant changes in GCIPL thicknesses were 
      evident. However, upon more pronounced shifting, the average GCIPL thickness of 
      the direction of the shift region was significantly lower than baseline, whereas 
      the GCIPL of the diametrically opposite sector was thicker than baseline. 
      CONCLUSIONS: The impact of changes associated with shifting of the measurement 
      center should be taken into consideration when measuring GCIPL thickness in 
      patients with retinal diseases, glaucoma, or neuro-ophthalmological conditions.
FAU - Kim, Kyoung-Nam
AU  - Kim KN
AD  - Department of Ophthalmology, Chungnam National University College of Medicine, 
      Daejeon, Republic of Korea.
FAU - Shin, Il-Hwan
AU  - Shin IH
AD  - Department of Ophthalmology, Chungnam National University College of Medicine, 
      Daejeon, Republic of Korea.
FAU - Kwak, Baek-Soo
AU  - Kwak BS
AD  - Department of Computer Engineering, San Jose State University, San Jose, 
      California.
FAU - Sung, Jae-Yun
AU  - Sung JY
AD  - Department of Ophthalmology, Chungnam National University College of Medicine, 
      Daejeon, Republic of Korea.
FAU - Lim, Hyung-Bin
AU  - Lim HB
AD  - Department of Ophthalmology, Chungnam National University College of Medicine, 
      Daejeon, Republic of Korea.
FAU - Jo, Young-Joon
AU  - Jo YJ
AD  - Department of Ophthalmology, Chungnam National University College of Medicine, 
      Daejeon, Republic of Korea.
AD  - Research Institute for Medical Science, Chungnam National University College of 
      Medicine, Daejeon, Republic of Korea *kimjy@cnu.ac.kr.
FAU - Kim, Jung-Yeul
AU  - Kim JY
AD  - Department of Ophthalmology, Chungnam National University College of Medicine, 
      Daejeon, Republic of Korea.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Optom Vis Sci
JT  - Optometry and vision science : official publication of the American Academy of 
      Optometry
JID - 8904931
SB  - IM
MH  - Adult
MH  - *Axons
MH  - Female
MH  - Fovea Centralis
MH  - Healthy Volunteers
MH  - Humans
MH  - Macula Lutea
MH  - Male
MH  - Middle Aged
MH  - Organ Size
MH  - Prospective Studies
MH  - Retinal Ganglion Cells/*cytology
MH  - Tomography, Optical Coherence/methods
EDAT- 2018/08/01 06:00
MHDA- 2019/10/12 06:00
CRDT- 2018/08/01 06:00
PHST- 2018/08/01 06:00 [pubmed]
PHST- 2019/10/12 06:00 [medline]
PHST- 2018/08/01 06:00 [entrez]
AID - 10.1097/OPX.0000000000001251 [doi]
PST - ppublish
SO  - Optom Vis Sci. 2018 Aug;95(8):656-662. doi: 10.1097/OPX.0000000000001251.