PMID- 30065792
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220318
IS  - 1555-8932 (Print)
IS  - 1865-3499 (Electronic)
IS  - 1555-8932 (Linking)
VI  - 13
DP  - 2018
TI  - High nutrient intake during the early postnatal period accelerates skeletal 
      muscle fiber growth and maturity in intrauterine growth-restricted pigs.
PG  - 23
LID - 10.1186/s12263-018-0612-8 [doi]
LID - 23
AB  - BACKGROUND: Intrauterine growth-restricted (IUGR) neonates impair postnatal 
      skeletal muscle growth. The aim of this study was to investigate whether high 
      nutrient intake (HNI) during the suckling period could improve muscle growth and 
      metabolic status of IUGR pigs. METHODS: Twelve pairs of IUGR and normal birth 
      weight (NBW) pigs (7 days old) were randomly assigned to adequate nutrient intake 
      and HNI formula milk groups. Psoas major (PM) muscle sample was obtained after 
      21 days of rearing. RESULTS: IUGR decreased cross-sectional areas (CSA) and 
      myofiber numbers, activity of lactate dehydrogenase (LDH), and mRNA expression of 
      insulin-like growth factor 1 (IGF-1), IGF-1 receptor (IGF-1R), mammalian target 
      of rapamycin (mTOR), ribosomal protein s6 (RPS6), eukaryotic translation 
      initiation factor 4E (eIF4E), protein expression of phosphorylated mTOR (P-mTOR), 
      and phosphorylated protein kinase B (P-Akt) in the PM muscle of pigs. 
      Irrespective of birth weight, HNI increased muscle weight and CSA, the 
      concentration of RNA, and ratio of RNA to DNA, as well as ratio of LDH to 
      beta-hydroxy-acyl-CoA-dehydrogenase in the PM muscle of pigs. Furthermore, HNI 
      increased percentages of MyHC IIb, mRNA expression of IGF-1, IGF-1R, Akt, mTOR, 
      RPS6, and eIF4E, as well as protein expression of P-mTOR, P-Akt, P-RPS6, and 
      P-eIF4E in the PM muscle of pigs. CONCLUSION: The present findings suggest that 
      high nutrient intake during the suckling period could improve skeletal muscle 
      growth and maturity, which is associated with increasing the expression of 
      protein deposition-related genes and accelerating the development of 
      glycolytic-type myofiber in pigs.
FAU - Hu, Liang
AU  - Hu L
AD  - Institute of Animal Nutrition, Key Laboratory of Animal Disease-Resistance 
      Nutrition, Sichuan Agricultural University, Ministry of Education, No.211 Huimin 
      Road, Wenjiang District, Chengdu, 611130 Sichuan People's Republic of China. 
      ISNI: 0000 0004 0369 313X. GRID: grid.419897.a
FAU - Han, Fei
AU  - Han F
AD  - Institute of Animal Nutrition, Key Laboratory of Animal Disease-Resistance 
      Nutrition, Sichuan Agricultural University, Ministry of Education, No.211 Huimin 
      Road, Wenjiang District, Chengdu, 611130 Sichuan People's Republic of China. 
      ISNI: 0000 0004 0369 313X. GRID: grid.419897.a
FAU - Chen, Lin
AU  - Chen L
AD  - Institute of Animal Nutrition, Key Laboratory of Animal Disease-Resistance 
      Nutrition, Sichuan Agricultural University, Ministry of Education, No.211 Huimin 
      Road, Wenjiang District, Chengdu, 611130 Sichuan People's Republic of China. 
      ISNI: 0000 0004 0369 313X. GRID: grid.419897.a
FAU - Peng, Xie
AU  - Peng X
AD  - Institute of Animal Nutrition, Key Laboratory of Animal Disease-Resistance 
      Nutrition, Sichuan Agricultural University, Ministry of Education, No.211 Huimin 
      Road, Wenjiang District, Chengdu, 611130 Sichuan People's Republic of China. 
      ISNI: 0000 0004 0369 313X. GRID: grid.419897.a
FAU - Chen, Daiwen
AU  - Chen D
AD  - Institute of Animal Nutrition, Key Laboratory of Animal Disease-Resistance 
      Nutrition, Sichuan Agricultural University, Ministry of Education, No.211 Huimin 
      Road, Wenjiang District, Chengdu, 611130 Sichuan People's Republic of China. 
      ISNI: 0000 0004 0369 313X. GRID: grid.419897.a
FAU - Wu, De
AU  - Wu D
AD  - Institute of Animal Nutrition, Key Laboratory of Animal Disease-Resistance 
      Nutrition, Sichuan Agricultural University, Ministry of Education, No.211 Huimin 
      Road, Wenjiang District, Chengdu, 611130 Sichuan People's Republic of China. 
      ISNI: 0000 0004 0369 313X. GRID: grid.419897.a
FAU - Che, Lianqiang
AU  - Che L
AUID- ORCID: 0000-0001-5263-9314
AD  - Institute of Animal Nutrition, Key Laboratory of Animal Disease-Resistance 
      Nutrition, Sichuan Agricultural University, Ministry of Education, No.211 Huimin 
      Road, Wenjiang District, Chengdu, 611130 Sichuan People's Republic of China. 
      ISNI: 0000 0004 0369 313X. GRID: grid.419897.a
FAU - Zhang, Keying
AU  - Zhang K
AD  - Institute of Animal Nutrition, Key Laboratory of Animal Disease-Resistance 
      Nutrition, Sichuan Agricultural University, Ministry of Education, No.211 Huimin 
      Road, Wenjiang District, Chengdu, 611130 Sichuan People's Republic of China. 
      ISNI: 0000 0004 0369 313X. GRID: grid.419897.a
LA  - eng
PT  - Journal Article
DEP - 20180727
PL  - Germany
TA  - Genes Nutr
JT  - Genes & nutrition
JID - 101280108
PMC - PMC6062929
OTO - NOTNLM
OT  - Birth weight
OT  - Metabolic status
OT  - Nutrient intake
OT  - Pigs
OT  - Skeletal muscle
COIS- All institutional and national guidelines for the care and use of laboratory 
      animals were followed. The experimental procedures were approved by the Animal 
      Care and Use Committee of Sichuan Agricultural University.The authors declare 
      that they have no competing interests.Springer Nature remains neutral with regard 
      to jurisdictional claims in published maps and institutional affiliations.
EDAT- 2018/08/02 06:00
MHDA- 2018/08/02 06:01
PMCR- 2018/07/27
CRDT- 2018/08/02 06:00
PHST- 2018/02/08 00:00 [received]
PHST- 2018/07/12 00:00 [accepted]
PHST- 2018/08/02 06:00 [entrez]
PHST- 2018/08/02 06:00 [pubmed]
PHST- 2018/08/02 06:01 [medline]
PHST- 2018/07/27 00:00 [pmc-release]
AID - 612 [pii]
AID - 10.1186/s12263-018-0612-8 [doi]
PST - epublish
SO  - Genes Nutr. 2018 Jul 27;13:23. doi: 10.1186/s12263-018-0612-8. eCollection 2018.