PMID- 30066262
OWN - NLM
STAT- MEDLINE
DCOM- 20190717
LR  - 20190717
IS  - 1554-3528 (Electronic)
IS  - 1554-351X (Linking)
VI  - 51
IP  - 1
DP  - 2019 Feb
TI  - Comparison of model- and design-based approaches to detect the treatment effect 
      and covariate by treatment interactions in three-level models for multisite 
      cluster-randomized trials.
PG  - 243-257
LID - 10.3758/s13428-018-1080-1 [doi]
AB  - In this study, we evaluated the estimation of three important parameters for data 
      collected in a multisite cluster-randomized trial (MS-CRT): the treatment effect, 
      and the treatment by covariate interactions at Levels 1 and 2. The Level 1 and 
      Level 2 interaction parameters are the coefficients for the products of the 
      treatment indicator, with the covariate centered on its Level 2 expected value 
      and with the Level 2 expected value centered on its Level 3 expected value, 
      respectively. A comparison of a model-based approach to design-based approaches 
      was performed using simulation studies. The results showed that both approaches 
      produced similar treatment effect estimates and interaction estimates at Level 1, 
      as well as similar Type I error rates and statistical power. However, the 
      estimate of the Level 2 interaction coefficient for the product of the treatment 
      indicator and an arithmetic mean of the Level 1 covariate was severely biased in 
      most conditions. Therefore, applied researchers should be cautious when using 
      arithmetic means to form a treatment by covariate interaction at Level 2 in 
      MS-CRT data.
FAU - Aydin, Burak
AU  - Aydin B
AD  - School of Education, Recep Tayyip Erdogan University, Rize, Turkey. 
      burak.aydin@erdogan.edu.tr.
FAU - Algina, James
AU  - Algina J
AD  - School of Human Development and Organizational Studies in Education, University 
      of Florida, Gainesville, FL, USA.
FAU - L Leite, Walter
AU  - L Leite W
AD  - School of Human Development and Organizational Studies in Education, University 
      of Florida, Gainesville, FL, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Behav Res Methods
JT  - Behavior research methods
JID - 101244316
SB  - IM
MH  - *Cluster Analysis
MH  - Computer Simulation
MH  - Humans
MH  - *Models, Statistical
MH  - Multilevel Analysis/*methods
MH  - Randomized Controlled Trials as Topic/*methods
MH  - *Research Design
OTO - NOTNLM
OT  - Covariate by treatment interaction
OT  - Design-based
OT  - Model-based
OT  - Multisite cluster-randomized trials
OT  - Three-level models
EDAT- 2018/08/02 06:00
MHDA- 2019/07/18 06:00
CRDT- 2018/08/02 06:00
PHST- 2018/08/02 06:00 [pubmed]
PHST- 2019/07/18 06:00 [medline]
PHST- 2018/08/02 06:00 [entrez]
AID - 10.3758/s13428-018-1080-1 [pii]
AID - 10.3758/s13428-018-1080-1 [doi]
PST - ppublish
SO  - Behav Res Methods. 2019 Feb;51(1):243-257. doi: 10.3758/s13428-018-1080-1.