PMID- 30067069
OWN - NLM
STAT- MEDLINE
DCOM- 20181218
LR  - 20181218
IS  - 1205-7541 (Electronic)
IS  - 0008-4212 (Linking)
VI  - 96
IP  - 10
DP  - 2018 Oct
TI  - Efficiency of atorvastatin and simvastatin in improving cardiac function during 
      the different degrees of hyperhomocysteinemia.
PG  - 1040-1049
LID - 10.1139/cjpp-2018-0102 [doi]
AB  - The aim of this study was to assess the impact of atorvastatin and simvastatin on 
      myocardial contractility during the different degrees of hyperhomocysteinemia 
      (HHcy) in rats. Study was conducted on adult male Wistar albino rats (n = 90; 4 
      weeks old; 100 +/- 15 g body mass) in which HHcy was achieved by dietary 
      manipulation. Animals were exposed to pharmacology treatment with atorvastatin in 
      dose of 3 mg/kg per day i.p. or simvastatin in dose of 5 mg/kg per day i.p. at 
      the same time every day, according to equivalent therapeutic doses of these 
      statins (10 mg atorvastatin = 20 mg simvastatin). After the dietary manipulation 
      and pharmacological treatment and confirmation of HHcy, all animals were 
      sacrificed, hearts were isolated, and cardiac function was tested according to 
      the Langendorff technique. Size of recovery of maximum rate of left ventricular 
      development (dp/dt(max)), minimum rate of left ventricular development 
      (dp/dt(min)), systolic left ventricular development, diastolic left ventricular 
      development, heart rate, and coronary flow at the 40, 60, 80, 100, and 120 
      cmH(2)O coronary perfusion pressure were measured in state of physiological 
      condition (homocysteine less than 15 mumol/L), mild HHcy, and moderate HHcy. 
      Atorvastatin treatment significantly attenuated homocysteine-induced impairment 
      of myocyte contractility and dominantly decreased dp/dt(max), dp/dt(min), and 
      heart rate and induced greater changes in systolic left ventricular development 
      compared with simvastatin. Treatment with atorvastatin seems able to revert 
      systolic abnormalities and improve contractility during the different degrees of 
      HHcy.
FAU - Nikolic Turnic, Tamara R
AU  - Nikolic Turnic TR
AD  - a Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, 
      Kragujevac, Serbia.
FAU - Jakovljevic, Vladimir Lj
AU  - Jakovljevic VL
AD  - b Department of Physiology, Faculty of Medical Sciences, University of 
      Kragujevac, Kragujevac, Serbia.
AD  - c Department of Human Pathology, IM Sechenov 1st Moscow State Medical University, 
      Moscow, Russian Federation.
FAU - Djuric, Dragan M
AU  - Djuric DM
AD  - d Institute of Medical Physiology "Richard Burian", School of Medicine, 
      University of Belgrade, Belgrade, Serbia.
FAU - Jeremic, Nevena S
AU  - Jeremic NS
AD  - a Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, 
      Kragujevac, Serbia.
FAU - Jeremic, Jovana N
AU  - Jeremic JN
AD  - a Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, 
      Kragujevac, Serbia.
FAU - Milosavljevic, Isidora M
AU  - Milosavljevic IM
AD  - a Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, 
      Kragujevac, Serbia.
FAU - Srejovic, Ivan M
AU  - Srejovic IM
AD  - b Department of Physiology, Faculty of Medical Sciences, University of 
      Kragujevac, Kragujevac, Serbia.
FAU - Selakovic, Dragica V
AU  - Selakovic DV
AD  - b Department of Physiology, Faculty of Medical Sciences, University of 
      Kragujevac, Kragujevac, Serbia.
FAU - Zivkovic, Vladimir I
AU  - Zivkovic VI
AD  - b Department of Physiology, Faculty of Medical Sciences, University of 
      Kragujevac, Kragujevac, Serbia.
LA  - eng
PT  - Journal Article
DEP - 20180801
PL  - Canada
TA  - Can J Physiol Pharmacol
JT  - Canadian journal of physiology and pharmacology
JID - 0372712
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - A0JWA85V8F (Atorvastatin)
RN  - AGG2FN16EV (Simvastatin)
SB  - IM
MH  - Animals
MH  - Atorvastatin/*pharmacology
MH  - Heart/*drug effects/*physiopathology
MH  - Homocysteine/metabolism
MH  - Hyperhomocysteinemia/metabolism/*physiopathology
MH  - Male
MH  - Rats
MH  - Rats, Wistar
MH  - Recovery of Function/drug effects
MH  - Simvastatin/*pharmacology
OTO - NOTNLM
OT  - cardiac function
OT  - fonction cardiaque
OT  - hydroxymethyl glutaryl coenzyme A reductase inhibitors
OT  - hyperhomocysteinemia
OT  - hyperhomocysteinemie
OT  - inhibiteurs de l'hydroxymethyl glutaryl coenzyme A reductase
OT  - rat
EDAT- 2018/08/02 06:00
MHDA- 2018/12/19 06:00
CRDT- 2018/08/02 06:00
PHST- 2018/08/02 06:00 [pubmed]
PHST- 2018/12/19 06:00 [medline]
PHST- 2018/08/02 06:00 [entrez]
AID - 10.1139/cjpp-2018-0102 [doi]
PST - ppublish
SO  - Can J Physiol Pharmacol. 2018 Oct;96(10):1040-1049. doi: 10.1139/cjpp-2018-0102. 
      Epub 2018 Aug 1.