PMID- 3006867
OWN - NLM
STAT- MEDLINE
DCOM- 19860522
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 368
IP  - 1
DP  - 1986 Mar 12
TI  - Brain dopamine depletion by lesions in the substantia nigra attenuates the 
      development of hypertension in the spontaneously hypertensive rat.
PG  - 69-78
AB  - The involvement of brain dopamine in the development of hypertension in the 
      spontaneously hypertensive rat (SHR) was studied. Intracerebroventricular 
      (i.c.v.) injections of 6-hydroxydopamine (6-OHDA) in young SHR caused depletion 
      of dopamine in frontal cortex and striatum and induced an attenuation of the 
      development of hypertension in SHR. Depletion of noradrenaline and to a lesser 
      extent of serotonin was found as well. The ratio of DOPAC and of HVA to dopamine 
      was increased after 6-OHDA. Pretreatment with the dopamine re-uptake inhibitor 
      GBR-12909 inhibited the effects of 6-OHDA on both blood pressure and brain 
      dopamine content. The effect of 6-OHDA on noradrenaline and serotonin levels were 
      not influenced by pretreatment with GBR-12909. Electrolytic lesions in the 
      substantia nigra delayed the rise in blood pressure in SHR. Lesions in the 
      ventral tegmental area (VTA) were ineffective. After substantia nigra lesions 
      depletion of dopamine was found especially in the nucleus caudatus posterior and 
      the dorsomedial nucleus. After lesions in the VTA substantial dopamine depletion 
      was found in the nucleus accumbens, frontal cortex, lateral septal nucleus and 
      zona incerta. These data suggest that brain dopamine systems play a role in the 
      development of hypertension in SHR and that especially the nigrostriatal system 
      is important in this respect. Moreover, the present results may help to explain 
      the attenuating effect of prehypertensive treatment with 6-OHDA on the 
      development of hypertension.
FAU - van den Buuse, M
AU  - van den Buuse M
FAU - Versteeg, D H
AU  - Versteeg DH
FAU - de Jong, W
AU  - de Jong W
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Hydroxydopamines)
RN  - 8HW4YBZ748 (Oxidopamine)
RN  - VTD58H1Z2X (Dopamine)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Animals
MH  - Brain/*physiopathology
MH  - Dopamine/*physiology
MH  - Hydroxydopamines
MH  - Hypertension/*physiopathology
MH  - Injections, Intraventricular
MH  - Male
MH  - Norepinephrine/physiology
MH  - Oxidopamine
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Rats, Inbred WKY
MH  - Substantia Nigra/physiopathology
MH  - Synaptic Transmission
MH  - Tegmentum Mesencephali/physiopathology
EDAT- 1986/03/12 00:00
MHDA- 1986/03/12 00:01
CRDT- 1986/03/12 00:00
PHST- 1986/03/12 00:00 [pubmed]
PHST- 1986/03/12 00:01 [medline]
PHST- 1986/03/12 00:00 [entrez]
AID - 0006-8993(86)91043-7 [pii]
AID - 10.1016/0006-8993(86)91043-7 [doi]
PST - ppublish
SO  - Brain Res. 1986 Mar 12;368(1):69-78. doi: 10.1016/0006-8993(86)91043-7.