PMID- 30069271
OWN - NLM
STAT- MEDLINE
DCOM- 20181030
LR  - 20220321
IS  - 1875-8630 (Electronic)
IS  - 0278-0240 (Print)
IS  - 0278-0240 (Linking)
VI  - 2018
DP  - 2018
TI  - Clinical Applications of Adiponectin Measurements in Type 2 Diabetes Mellitus: 
      Screening, Diagnosis, and Marker of Diabetes Control.
PG  - 5187940
LID - 10.1155/2018/5187940 [doi]
LID - 5187940
AB  - BACKGROUND: Adipose tissue-derived adiponectin has pleiotropic protective effects 
      with suppression of inflammatory and metabolic derangements that may result in 
      insulin resistance, metabolic syndrome, type 2 diabetes mellitus (T2DM), and 
      cardiovascular disease. The aim of this study was to evaluate adiponectin as a 
      diagnostic marker of T2DM and diabetes control. METHODS: Fasting adiponectin, 
      insulin, glucose, and HbA1c were determined in 376 patients with known T2DM and 
      575 subjects with undiagnosed diabetes but with family history of T2DM. Clinical 
      and anthropometric data were recorded. Subjects were classified on the basis of 
      degree of adiposity, insulin resistance (IR), and achievement of target HbA1c 
      levels. Receiver operating characteristic (ROC) curve analysis was used to 
      examine the diagnostic performance for undiagnosed DM. RESULTS: In undiagnosed 
      subjects, adiponectin was significantly lower in subjects with IR and diabetic 
      subjects compared with those without. The area under the adiponectin ROC curve 
      for diagnosis of DM was 0.740. In known T2DM subjects, those with good control 
      had significantly higher adiponectin (8.6 versus 7.4 mug/mL) compared to subjects 
      with poor control. CONCLUSIONS: Adiponectin levels are associated with better 
      glycemic control and could be a useful adjunct for screening for IR and T2DM. 
      Therapeutic measures that increase adiponectin levels might be valuable targets 
      for improving diabetes control and decreasing complications.
FAU - Abdella, Nabila A
AU  - Abdella NA
AUID- ORCID: 0000-0001-8344-144X
AD  - Department of Medicine, Faculty of Medicine, Kuwait University, Safat, Kuwait.
FAU - Mojiminiyi, Olusegun A
AU  - Mojiminiyi OA
AUID- ORCID: 0000-0002-3353-328X
AD  - Department of Pathology, Faculty of Medicine, Kuwait University, Safat, Kuwait.
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20180705
PL  - United States
TA  - Dis Markers
JT  - Disease markers
JID - 8604127
RN  - 0 (Adiponectin)
RN  - 0 (Biomarkers)
SB  - IM
MH  - Adiponectin/*blood
MH  - Adolescent
MH  - Adult
MH  - Biomarkers/blood
MH  - Diabetes Mellitus, Type 2/*blood/drug therapy
MH  - Female
MH  - Humans
MH  - Insulin Resistance
MH  - Male
PMC - PMC6057311
EDAT- 2018/08/03 06:00
MHDA- 2018/10/31 06:00
PMCR- 2018/07/05
CRDT- 2018/08/03 06:00
PHST- 2017/12/27 00:00 [received]
PHST- 2018/06/02 00:00 [accepted]
PHST- 2018/08/03 06:00 [entrez]
PHST- 2018/08/03 06:00 [pubmed]
PHST- 2018/10/31 06:00 [medline]
PHST- 2018/07/05 00:00 [pmc-release]
AID - 10.1155/2018/5187940 [doi]
PST - epublish
SO  - Dis Markers. 2018 Jul 5;2018:5187940. doi: 10.1155/2018/5187940. eCollection 
      2018.