PMID- 30070307
OWN - NLM
STAT- MEDLINE
DCOM- 20191113
LR  - 20191113
IS  - 2284-0729 (Electronic)
IS  - 1128-3602 (Linking)
VI  - 22
IP  - 15
DP  - 2018 Aug
TI  - IFN-gamma induces upregulation of TNF-alpha, downregulation of MMP-2 and MMP-9 
      expressions in abortion rat.
PG  - 4762-4767
LID - 15609 [pii]
LID - 10.26355/eurrev_201808_15609 [doi]
AB  - OBJECTIVE: Tumor necrosis factor-alpha (TNF-alpha) participates in the regulation of the 
      whole process of pregnancy. Matrix metalloproteinases-2 and -9 (MMP-2 and MMP-9) 
      play important roles in the process of trophoblast invading decidua. This 
      research aims to determine the role of IFN-gamma in TNF-alpha, MMP-2, and MMP-9 of 
      abortion rats. MATERIALS AND METHODS: The rats were divided into control, 
      abortion model, gestation, and IFN-gamma group. Abortion rats model in IFN-gamma group 
      were treated by IFN-gamma at low and high doses upon abortion model. Serum and tissue 
      TNF-alpha, MMP-2, and MMP-9 expressions were detected by ELISA and 
      immunohistochemistry. RESULTS: The level of TNF-alpha was significantly elevated, 
      while MMP-2 and MMP-9 were statistically declined in the serum and decidual 
      tissue of rat from model group (p < 0.05). Of note, the expression of TNF-alpha was 
      further increased, whereas MMP-2 and MMP-9 reduced in IFN-gamma high dose group (p < 
      0.05). CONCLUSIONS: We demonstrated that in abortion rats, TNF-alpha was 
      overexpressed, while MMP-2 and MMP-9 were reduced declined in the serum and 
      decidual tissue. The treatment with a high dose of IFN-gamma further upregulated 
      TNF-alpha expression and decreased MMP-2 and MMP-9 levels, aggravating the severity 
      of rat abortion.
FAU - He, Y
AU  - He Y
AD  - Department of Obstetrics, Jinan Maternity and Child Care Hospital, Jinan, 
      Shandong, China. lzweivxsxzj@sina.com.
FAU - Sun, Q
AU  - Sun Q
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Eur Rev Med Pharmacol Sci
JT  - European review for medical and pharmacological sciences
JID - 9717360
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 82115-62-6 (Interferon-gamma)
RN  - EC 3.4.24.24 (Matrix Metalloproteinase 2)
RN  - EC 3.4.24.35 (Matrix Metalloproteinase 9)
SB  - IM
MH  - Abortion, Veterinary/metabolism/*pathology
MH  - Animals
MH  - Decidua/metabolism
MH  - Down-Regulation/*drug effects
MH  - Female
MH  - Interferon-gamma/*pharmacology
MH  - Matrix Metalloproteinase 2/*blood/metabolism
MH  - Matrix Metalloproteinase 9/*blood/metabolism
MH  - Pregnancy
MH  - Rats
MH  - Rats, Wistar
MH  - Tumor Necrosis Factor-alpha/*blood/metabolism
MH  - Up-Regulation/*drug effects
EDAT- 2018/08/03 06:00
MHDA- 2019/11/14 06:00
CRDT- 2018/08/03 06:00
PHST- 2018/08/03 06:00 [entrez]
PHST- 2018/08/03 06:00 [pubmed]
PHST- 2019/11/14 06:00 [medline]
AID - 15609 [pii]
AID - 10.26355/eurrev_201808_15609 [doi]
PST - ppublish
SO  - Eur Rev Med Pharmacol Sci. 2018 Aug;22(15):4762-4767. doi: 
      10.26355/eurrev_201808_15609.