PMID- 30071446
OWN - NLM
STAT- MEDLINE
DCOM- 20181127
LR  - 20200225
IS  - 1879-0046 (Electronic)
IS  - 0376-8716 (Print)
IS  - 0376-8716 (Linking)
VI  - 191
DP  - 2018 Oct 1
TI  - Correlation of cytokines, BDNF levels, and memory function in patients with 
      opioid use disorder undergoing methadone maintenance treatment.
PG  - 6-13
LID - S0376-8716(18)30388-0 [pii]
LID - 10.1016/j.drugalcdep.2018.06.024 [doi]
AB  - BACKGROUND: Patients with opioid use disorder (OUD) show memory deficiencies and 
      impaired treatment outcomes. Emerging evidence suggests that opioid abuse 
      activates proinflammatory processes by increasing cytokine production and 
      impairing neuroprotection, which damages the memory function in OUD patients. 
      Therefore, we investigated whether plasma-based inflammatory and neurotrophic 
      markers correlate with memory function in OUD patients. METHOD: OUD patients 
      undergoing methadone maintenance therapy (MMT) were investigated and followed up 
      for 12 weeks. Plasma tumor necrosis factor (TNF)-alpha, C-reactive protein (CRP), 
      interleukin (IL)-6, transforming growth factor (TGF)-beta1, brain-derived 
      neurotrophic factor (BDNF) levels, and Wechsler Memory Scale-Revised (WMS-R) 
      scores were assessed at baseline and after 12 weeks of MMT. Multiple linear 
      regressions and generalized estimating equations (GEEs) were used to examine the 
      correlation between cytokines and memory performance. RESULTS: We enrolled 89 
      patients at baseline; 47 patients completed the end-of-study assessments. 
      Although Pearson correlations showed that CRP and TGF-beta1 levels were 
      significantly, negatively associated with some memory indices, the results were 
      not significant after correction. The GEE results, controlled for several 
      confounding factors and multiple testing, showed that changes in TNF-alpha levels 
      were negatively correlated with changes in the visual memory index (P = 0.01), 
      and that changes in IL-6 levels were negatively correlated with changes in the 
      verbal memory index (P = 0.009). CONCLUSION: Memory performance, TNF-alpha, and IL-6 
      levels in OUD patients were negative correlated. Additional studies on regulating 
      TNF-alpha and IL-6 expression to improve memory function in OUD patients might be 
      warranted.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Wang, Tzu-Yun
AU  - Wang TY
AD  - Department of Psychiatry, National Cheng Kung University Hospital, College of 
      Medicine, National Cheng Kung University, 138 Sheng-Li Road, Tainan 70428, 
      Taiwan; Department of Psychiatry, National Cheng Kung University Hospital, 
      Dou-Liou Branch, No. 345, Zhuangjing Road, Douliu, Yunlin 64043, Taiwan. 
      Electronic address: n622498@mail.hosp.ncku.edu.tw.
FAU - Lee, Sheng-Yu
AU  - Lee SY
AD  - Department of Psychiatry, National Cheng Kung University Hospital, College of 
      Medicine, National Cheng Kung University, 138 Sheng-Li Road, Tainan 70428, 
      Taiwan; Department of Psychiatry, Kaohsiung Veterans General Hospital, No. 386, 
      Dazhong 1st Road, Zuoying Dist., Kaohsiung 81362, Taiwan.
FAU - Chang, Yun-Hsuan
AU  - Chang YH
AD  - Department of Psychiatry, National Cheng Kung University Hospital, College of 
      Medicine, National Cheng Kung University, 138 Sheng-Li Road, Tainan 70428, 
      Taiwan; Department of Psychology, Asia University, 500, Lioufeng Road, Wufeng, 
      Taichung 41354, Taiwan; Department of Medical Research, China Medical University 
      Hospital, China Medical University, No. 91, Hsueh-Shih Road, Taichung 40402, 
      Taiwan.
FAU - Chen, Shiou-Lan
AU  - Chen SL
AD  - Department of Psychiatry, National Cheng Kung University Hospital, College of 
      Medicine, National Cheng Kung University, 138 Sheng-Li Road, Tainan 70428, 
      Taiwan; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical 
      University, 100, Shih-Chuan 1st Road, Kaohsiung 80708, Taiwan; Lipid Science and 
      Aging Research Center, Kaohsiung Medical University, 100, Shih-Chuan 1st Road, 
      Kaohsiung 80708, Taiwan.
FAU - Chen, Po See
AU  - Chen PS
AD  - Department of Psychiatry, National Cheng Kung University Hospital, College of 
      Medicine, National Cheng Kung University, 138 Sheng-Li Road, Tainan 70428, 
      Taiwan; Institute of Behavioral Medicine, College of Medicine, National Cheng 
      Kung University, 138 Sheng-Li Road, Tainan 70428, Taiwan.
FAU - Chu, Chun-Hsien
AU  - Chu CH
AD  - Institute of Molecular Medicine, College of Medicine, National Cheng Kung 
      University, 3F, No. 367, Sheng-Li Rd., North District, Tainan 70456, Taiwan.
FAU - Huang, San-Yuan
AU  - Huang SY
AD  - Department of Psychiatry, Tri-Service General Hospital, School of Medicine, 
      National Defense Medical Center, No. 325, Sec. 2, Chenggong Road., Neihu 
      District, Taipei 11490, Taiwan.
FAU - Tzeng, Nian-Sheng
AU  - Tzeng NS
AD  - Department of Psychiatry, Tri-Service General Hospital, School of Medicine, 
      National Defense Medical Center, No. 325, Sec. 2, Chenggong Road., Neihu 
      District, Taipei 11490, Taiwan; Student Counseling Center, National Defense 
      Medical Center, No.161, Sec. 6, Minquan E. Road., Neihu Dist., Taipei 11490, 
      Taipei, Taiwan.
FAU - Lee, I Hui
AU  - Lee IH
AD  - Department of Psychiatry, National Cheng Kung University Hospital, College of 
      Medicine, National Cheng Kung University, 138 Sheng-Li Road, Tainan 70428, 
      Taiwan.
FAU - Chen, Kao Chin
AU  - Chen KC
AD  - Department of Psychiatry, National Cheng Kung University Hospital, College of 
      Medicine, National Cheng Kung University, 138 Sheng-Li Road, Tainan 70428, 
      Taiwan.
FAU - Yang, Yen Kuang
AU  - Yang YK
AD  - Department of Psychiatry, National Cheng Kung University Hospital, College of 
      Medicine, National Cheng Kung University, 138 Sheng-Li Road, Tainan 70428, 
      Taiwan; Department of Psychiatry, National Cheng Kung University Hospital, 
      Dou-Liou Branch, No. 345, Zhuangjing Road, Douliu, Yunlin 64043, Taiwan; 
      Institute of Behavioral Medicine, College of Medicine, National Cheng Kung 
      University, 138 Sheng-Li Road, Tainan 70428, Taiwan.
FAU - Chen, Shih-Heng
AU  - Chen SH
AD  - Neurobiology Laboratory, NIEHS/NIH, Research Triangle Park, 111 T.W. Alexander 
      Drive, Research Triangle Park, NC 27709, USA.
FAU - Hong, Jau-Shyong
AU  - Hong JS
AD  - Neurobiology Laboratory, NIEHS/NIH, Research Triangle Park, 111 T.W. Alexander 
      Drive, Research Triangle Park, NC 27709, USA.
FAU - Lu, Ru-Band
AU  - Lu RB
AD  - Department of Psychiatry, National Cheng Kung University Hospital, College of 
      Medicine, National Cheng Kung University, 138 Sheng-Li Road, Tainan 70428, 
      Taiwan; Institute of Behavioral Medicine, College of Medicine, National Cheng 
      Kung University, 138 Sheng-Li Road, Tainan 70428, Taiwan; Beijing YiNing 
      Hospital, No. 9 Minzhuang Road, Haidian District, Beijing 100195, China; Center 
      for Neuropsychiatric Research, National Health Research Institutes, 35 Keyan 
      Road, Zhunan, Miaoli County 35053, Taiwan.
LA  - eng
GR  - Z01 ES090082/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180725
PL  - Ireland
TA  - Drug Alcohol Depend
JT  - Drug and alcohol dependence
JID - 7513587
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - UC6VBE7V1Z (Methadone)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - C-Reactive Protein/analysis
MH  - Female
MH  - Humans
MH  - Interleukin-6/*blood
MH  - Male
MH  - Memory/*physiology
MH  - Memory Disorders/*blood/chemically induced
MH  - Methadone/therapeutic use
MH  - Middle Aged
MH  - Opiate Substitution Treatment/methods
MH  - Opioid-Related Disorders/*blood/complications/drug therapy
MH  - Treatment Outcome
MH  - Tumor Necrosis Factor-alpha/blood
PMC - PMC6487886
MID - NIHMS1525696
OTO - NOTNLM
OT  - Brain-derived neurotrophic factor
OT  - Cognitive function
OT  - Cytokines
OT  - Memory
OT  - Opioid use disorder
EDAT- 2018/08/03 06:00
MHDA- 2018/11/28 06:00
PMCR- 2019/04/29
CRDT- 2018/08/03 06:00
PHST- 2018/03/13 00:00 [received]
PHST- 2018/05/16 00:00 [revised]
PHST- 2018/06/18 00:00 [accepted]
PHST- 2018/08/03 06:00 [pubmed]
PHST- 2018/11/28 06:00 [medline]
PHST- 2018/08/03 06:00 [entrez]
PHST- 2019/04/29 00:00 [pmc-release]
AID - S0376-8716(18)30388-0 [pii]
AID - 10.1016/j.drugalcdep.2018.06.024 [doi]
PST - ppublish
SO  - Drug Alcohol Depend. 2018 Oct 1;191:6-13. doi: 10.1016/j.drugalcdep.2018.06.024. 
      Epub 2018 Jul 25.