PMID- 30072828
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 0970-1915 (Print)
IS  - 0974-0422 (Electronic)
IS  - 0970-1915 (Linking)
VI  - 33
IP  - 3
DP  - 2018 Jul
TI  - Plasma Fatty Acid Composition and Estimated Desaturase Activities Reflect Dietary 
      Patterns in Subjects with Metabolic Syndrome.
PG  - 290-296
LID - 10.1007/s12291-017-0674-1 [doi]
AB  - Changes in plasma fatty acid (FA) composition and desaturase activities are 
      observed in metabolic syndrome (MS). However, whether these changes are a 
      reflection of dietary intakes of fats and FAs is not well established. The 
      current study was aimed at assessing plasma FA composition and desaturase enzyme 
      activities as biomarkers of dietary intakes in subjects with MS. Case control 
      study was done on 41 MS patients and was compared with age matched 45 controls. 
      Dietary intakes, anthropometric and clinical parameters were measured. FA 
      composition was analysed using gas chromatography-flame ionisation detector and 
      desaturase enzyme activities were estimated as ratios of product to precursor 
      FAs. Higher levels of 14:0, 16:0, 16:1, 18:1, D9D-18 activity and lower levels of 
      18:0 and 18:2 n-6 were seen in MS group when compared to controls (p < 0.05). 
      Strong positive correlations were seen between plasma triglyceride (TG) levels 
      and 14:0, 16:0, 16:1, 18:1, total saturated fatty acid, total monounsaturated 
      fatty acid, and D9D activities, while 18:0, 18:2 n-6 and total polyunsaturated 
      fatty acid were negatively correlated with TG. Positive correlations were seen 
      between plasma 14:0, 18:1 and D9D-18 activity with total energy intake and 
      carbohydrate (CHO) intakes but not with fat intake. Plasma FA profile appears to 
      be a better index of total energy intake and CHO intake than fat intake, 
      suggesting it might be a good reflection of endogenous FA metabolism. Changes in 
      FA composition may therefore serve as an early index of dysregulation of FA 
      metabolism, resulting in increased risk of MS.
FAU - Pavithra, N
AU  - Pavithra N
AD  - 1Division of Nutrition, St. John's Research Institute, St. John's Medical 
      College, Bangalore, 560034 India. ISNI: 0000 0004 1770 8558. GRID: grid.416432.6
FAU - Bannikoppa, Priyanka S
AU  - Bannikoppa PS
AD  - 1Division of Nutrition, St. John's Research Institute, St. John's Medical 
      College, Bangalore, 560034 India. ISNI: 0000 0004 1770 8558. GRID: grid.416432.6
FAU - Uthappa, Sheila
AU  - Uthappa S
AD  - 2Department of Biochemistry, St. John's Medical College, Bangalore, India. ISNI: 
      0000 0004 1770 8558. GRID: grid.416432.6
FAU - Kurpad, Anura V
AU  - Kurpad AV
AD  - 1Division of Nutrition, St. John's Research Institute, St. John's Medical 
      College, Bangalore, 560034 India. ISNI: 0000 0004 1770 8558. GRID: grid.416432.6
FAU - Mani, Indu
AU  - Mani I
AD  - 1Division of Nutrition, St. John's Research Institute, St. John's Medical 
      College, Bangalore, 560034 India. ISNI: 0000 0004 1770 8558. GRID: grid.416432.6
LA  - eng
PT  - Journal Article
DEP - 20170722
PL  - India
TA  - Indian J Clin Biochem
JT  - Indian journal of clinical biochemistry : IJCB
JID - 8708303
PMC - PMC6052719
OTO - NOTNLM
OT  - Delta 9-desaturase
OT  - Dietary carbohydrates
OT  - Endogenous fatty acid metabolism
OT  - Metabolic syndrome
OT  - Plasma fatty acids
COIS- Compliance with Ethical StandardsThe authors have no conflict of interest to 
      disclose.
EDAT- 2018/08/04 06:00
MHDA- 2018/08/04 06:01
PMCR- 2019/07/01
CRDT- 2018/08/04 06:00
PHST- 2016/12/02 00:00 [received]
PHST- 2017/06/26 00:00 [accepted]
PHST- 2018/08/04 06:00 [entrez]
PHST- 2018/08/04 06:00 [pubmed]
PHST- 2018/08/04 06:01 [medline]
PHST- 2019/07/01 00:00 [pmc-release]
AID - 674 [pii]
AID - 10.1007/s12291-017-0674-1 [doi]
PST - ppublish
SO  - Indian J Clin Biochem. 2018 Jul;33(3):290-296. doi: 10.1007/s12291-017-0674-1. 
      Epub 2017 Jul 22.