PMID- 30073358
OWN - NLM
STAT- MEDLINE
DCOM- 20190409
LR  - 20190409
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 59
IP  - 10
DP  - 2018 Aug 1
TI  - Deep Optic Nerve Head Morphology Is Associated With Pattern of Glaucomatous 
      Visual Field Defect in Open-Angle Glaucoma.
PG  - 3842-3851
LID - 10.1167/iovs.18-24588 [doi]
AB  - PURPOSE: We investigated the relationship between visual field (VF) defect 
      pattern and deep optic nerve head (ONH) morphology in open angle glaucoma (OAG) 
      eyes using spectral-domain optical coherence tomography (SD-OCT). METHODS: Of 278 
      OAG eyes, 169 with and 55 without externally oblique border tissue (EOBT) were 
      included in the final analysis. Enhance depth imaging SD-OCT was used to measure 
      the deep ONH parameters, such as EOBT length, ONH tilt angle, and optic canal 
      (OC) obliqueness. The extents and locations of the maximum deep ONH parameters 
      were explored according to VF pattern in OAG eyes. RESULTS: OAG eyes with EOBT 
      showed longer axial length (AL; 25.6 vs. 24.4 mm; P < 0.001) and greater superior 
      VF defects (67.5% vs. 49.1%; P = 0.02) compared to OAG eyes without EOBT. 
      Multivariate logistic regression analysis revealed that relatively inferior 
      location of maximum deep ONH parameters was associated with superior hemifield 
      defects dominant in OAG (P < 0.001 in all parameters). In addition, the locations 
      of maximum deep ONH parameters were consistent with dominant VF defect locations 
      in OAG eyes with AL < 24.5 mm. The presence of paracentral scotoma in OAG was 
      associated with worse mean deviation (MD) and relatively inferior location of 
      deep ONH parameters. CONCLUSIONS: The locations of maximum deep ONH parameters 
      were associated with the location of dominant VF defects and presence of 
      paracentral scotoma in OAG eyes.
FAU - Han, Jong Chul
AU  - Han JC
AD  - Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University 
      School of Medicine, Seoul, Korea.
FAU - Choi, Jae Hwan
AU  - Choi JH
AD  - Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University 
      School of Medicine, Seoul, Korea.
FAU - Park, Do Young
AU  - Park DY
AD  - Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University 
      School of Medicine, Seoul, Korea.
FAU - Lee, Eun Jung
AU  - Lee EJ
AD  - Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University 
      School of Medicine, Seoul, Korea.
FAU - Kee, Changwon
AU  - Kee C
AD  - Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University 
      School of Medicine, Seoul, Korea.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Aged
MH  - Cross-Sectional Studies
MH  - Female
MH  - Glaucoma, Open-Angle/*physiopathology
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Optic Disk/*pathology
MH  - Optic Nerve Diseases/*physiopathology
MH  - Tomography, Optical Coherence
MH  - Vision Disorders/physiopathology
MH  - Visual Fields/*physiology
EDAT- 2018/08/04 06:00
MHDA- 2019/04/10 06:00
CRDT- 2018/08/04 06:00
PHST- 2018/08/04 06:00 [entrez]
PHST- 2018/08/04 06:00 [pubmed]
PHST- 2019/04/10 06:00 [medline]
AID - 2696442 [pii]
AID - 10.1167/iovs.18-24588 [doi]
PST - ppublish
SO  - Invest Ophthalmol Vis Sci. 2018 Aug 1;59(10):3842-3851. doi: 
      10.1167/iovs.18-24588.