PMID- 30073617 OWN - NLM STAT- MEDLINE DCOM- 20190219 LR - 20200502 IS - 1573-2584 (Electronic) IS - 0301-1623 (Linking) VI - 50 IP - 11 DP - 2018 Nov TI - Left ventricular hypertrophy predicts the decline of glomerular filtration rate in patients with type 2 diabetes mellitus. PG - 2049-2059 LID - 10.1007/s11255-018-1942-6 [doi] AB - PURPOSE: The heart and kidney are of utmost importance for the maintenance of cardiovascular (CV) homeostasis. The relationship between cardiac remodeling, especially the left ventricular hypertrophy (LVH) and renal damage reflected by the estimated glomerular filtration rate (eGFR), decline in type 2 diabetes mellitus (T2DM) patients is unclear. And it is also unknown whether cardiac remodeling can be used to assess the eGFR decline in T2DM patients. METHODS: We retrospectively analyzed the relationship between cardiac remodeling especially the LVH and the eGFR decline for 265 patients with T2DM, who were diagnosed between 2011 and 2015 and followed for >/= 3 months. The parameters of cardiac remodeling were determined using Doppler echocardiography. RESULTS: In the Cox regression model, the parameters of cardiac remodeling were associated with the composite endpoint in different models. These associations were independent of age, body mass index (BMI), history of hypertension, duration of diabetes, the baseline eGFR, 24-h urinary protein, or using angiotensin-converting enzyme inhibitors (ACEI) and (or) angiotensin receptor blockers (ARB). The risk of composite endpoint in patients with T2DM was higher (hazard ratio, 10.832; p < 0.001 for trend) in the group with the highest number of abnormal echocardiographic parameters, than in the group with no abnormal echocardiographic parameters. In receiver operating characteristics (ROC) curve analyses, the parameter of left ventricular posterior wall (LVPW) thickness was superior to the other parameters of cardiac remodeling as represented by the higher area under the curve (AUC) values generated according to the sensitivity and specificity. CONCLUSION: Echocardiographic parameters are strongly correlated with the eGFR decline in patients with T2DM. Moreover, the severity of cardiac remodeling, especially the LVH is closely associated with the eGFR decline in patients with T2DM. Therefore, the recognition of cardiac structural alterations in patients with T2DM may evaluate renal damage at an early stage. FAU - Song, Haiying AU - Song H AD - Department of Nephrology, The Affiliated Shenzhen Second People's Hospital of Anhui Medical University, Shenzhen, 518035, Guangdong, China. AD - Department of Nephrology, The First Affiliated Hospital of Shenzhen University, Shenzhen University Health Science Center, Shenzhen, 518035, Guangdong, China. AD - Department of Nephrology, Shenzhen Second People's Hospital, No. 3002 Sungang Road, Futian District, Shenzhen, 518035, Guangdong, China. FAU - Hu, Haofei AU - Hu H AD - Department of Nephrology, The Affiliated Shenzhen Second People's Hospital of Anhui Medical University, Shenzhen, 518035, Guangdong, China. AD - Department of Nephrology, The First Affiliated Hospital of Shenzhen University, Shenzhen University Health Science Center, Shenzhen, 518035, Guangdong, China. AD - Department of Nephrology, Shenzhen Second People's Hospital, No. 3002 Sungang Road, Futian District, Shenzhen, 518035, Guangdong, China. FAU - Liao, Dehan AU - Liao D AD - Department of Nephrology, The Affiliated Shenzhen Second People's Hospital of Anhui Medical University, Shenzhen, 518035, Guangdong, China. AD - Department of Nephrology, The First Affiliated Hospital of Shenzhen University, Shenzhen University Health Science Center, Shenzhen, 518035, Guangdong, China. AD - Department of Nephrology, Shenzhen Second People's Hospital, No. 3002 Sungang Road, Futian District, Shenzhen, 518035, Guangdong, China. FAU - Wei, Jinghong AU - Wei J AD - Department of Nephrology, The Affiliated Shenzhen Second People's Hospital of Anhui Medical University, Shenzhen, 518035, Guangdong, China. AD - Department of Nephrology, The First Affiliated Hospital of Shenzhen University, Shenzhen University Health Science Center, Shenzhen, 518035, Guangdong, China. AD - Department of Nephrology, Shenzhen Second People's Hospital, No. 3002 Sungang Road, Futian District, Shenzhen, 518035, Guangdong, China. FAU - Wei, Cuimei AU - Wei C AD - Department of Nephrology, The Affiliated Shenzhen Second People's Hospital of Anhui Medical University, Shenzhen, 518035, Guangdong, China. AD - Department of Nephrology, The First Affiliated Hospital of Shenzhen University, Shenzhen University Health Science Center, Shenzhen, 518035, Guangdong, China. AD - Department of Nephrology, Shenzhen Second People's Hospital, No. 3002 Sungang Road, Futian District, Shenzhen, 518035, Guangdong, China. FAU - Liao, Fupeng AU - Liao F AD - Department of Nephrology, The Affiliated Shenzhen Second People's Hospital of Anhui Medical University, Shenzhen, 518035, Guangdong, China. AD - Department of Nephrology, The First Affiliated Hospital of Shenzhen University, Shenzhen University Health Science Center, Shenzhen, 518035, Guangdong, China. AD - Department of Nephrology, Shenzhen Second People's Hospital, No. 3002 Sungang Road, Futian District, Shenzhen, 518035, Guangdong, China. FAU - Zhou, Wenxiong AU - Zhou W AD - Department of Nephrology, The Affiliated Shenzhen Second People's Hospital of Anhui Medical University, Shenzhen, 518035, Guangdong, China. AD - Department of Nephrology, The First Affiliated Hospital of Shenzhen University, Shenzhen University Health Science Center, Shenzhen, 518035, Guangdong, China. AD - Department of Nephrology, Shenzhen Second People's Hospital, No. 3002 Sungang Road, Futian District, Shenzhen, 518035, Guangdong, China. FAU - Mo, Zihe AU - Mo Z AD - Department of Nephrology, The Affiliated Shenzhen Second People's Hospital of Anhui Medical University, Shenzhen, 518035, Guangdong, China. AD - Department of Nephrology, The First Affiliated Hospital of Shenzhen University, Shenzhen University Health Science Center, Shenzhen, 518035, Guangdong, China. AD - Department of Nephrology, Shenzhen Second People's Hospital, No. 3002 Sungang Road, Futian District, Shenzhen, 518035, Guangdong, China. FAU - Jiang, Shilun AU - Jiang S AD - Department of Nephrology, The Affiliated Shenzhen Second People's Hospital of Anhui Medical University, Shenzhen, 518035, Guangdong, China. AD - Department of Nephrology, The First Affiliated Hospital of Shenzhen University, Shenzhen University Health Science Center, Shenzhen, 518035, Guangdong, China. AD - Department of Nephrology, Shenzhen Second People's Hospital, No. 3002 Sungang Road, Futian District, Shenzhen, 518035, Guangdong, China. FAU - Ruan, Xiongzhong AU - Ruan X AD - Center for Nephrology, University College London, Rowland Hill Street, London, NW7 3SP, UK. xiongzruan@gmail.com. FAU - He, Yongcheng AU - He Y AD - Department of Nephrology, The Affiliated Shenzhen Second People's Hospital of Anhui Medical University, Shenzhen, 518035, Guangdong, China. heyongcheng@medmail.com.cn. AD - Department of Nephrology, The First Affiliated Hospital of Shenzhen University, Shenzhen University Health Science Center, Shenzhen, 518035, Guangdong, China. heyongcheng@medmail.com.cn. AD - Department of Nephrology, Shenzhen Second People's Hospital, No. 3002 Sungang Road, Futian District, Shenzhen, 518035, Guangdong, China. heyongcheng@medmail.com.cn. LA - eng GR - JCYJ20130329104904512, JCYJ20151029154245758, CXZZ20140421155346007, and CXZZ20150601140615135/the basic research project and technology development projects of Shenzhen Municipal Science and Technology Innovation Council/ GR - SZFZ2018063/the research project of Health and Family Planning Commission of Shenzhen Municipality/ PT - Journal Article DEP - 20180802 PL - Netherlands TA - Int Urol Nephrol JT - International urology and nephrology JID - 0262521 SB - IM MH - Adult MH - Aged MH - Diabetes Mellitus, Type 2/complications/*physiopathology MH - Echocardiography, Doppler MH - Female MH - *Glomerular Filtration Rate MH - Humans MH - Hypertrophy, Left Ventricular/diagnostic imaging/*etiology/physiopathology MH - Male MH - Middle Aged MH - Predictive Value of Tests MH - Retrospective Studies MH - Risk Factors MH - Ventricular Remodeling OTO - NOTNLM OT - Cardiac remodeling OT - Cardiovascular (CV) OT - Progression of renal damage OT - Type 2 diabetes mellitus (T2DM) EDAT- 2018/08/04 06:00 MHDA- 2019/03/21 06:00 CRDT- 2018/08/04 06:00 PHST- 2018/02/23 00:00 [received] PHST- 2018/07/14 00:00 [accepted] PHST- 2018/08/04 06:00 [pubmed] PHST- 2019/03/21 06:00 [medline] PHST- 2018/08/04 06:00 [entrez] AID - 10.1007/s11255-018-1942-6 [pii] AID - 10.1007/s11255-018-1942-6 [doi] PST - ppublish SO - Int Urol Nephrol. 2018 Nov;50(11):2049-2059. doi: 10.1007/s11255-018-1942-6. Epub 2018 Aug 2.