PMID- 30074176
OWN - NLM
STAT- MEDLINE
DCOM- 20181102
LR  - 20181114
IS  - 2523-899X (Electronic)
IS  - 2523-899X (Linking)
VI  - 38
IP  - 2
DP  - 2018 Apr
TI  - Correlation between Histone Deacetylase 9 and Regulatory T Cell in Patients with 
      Chronic Heart Failure.
PG  - 199-203
LID - 10.1007/s11596-018-1866-5 [doi]
AB  - Heart failure (HF) is the end stage of various kinds of cardiovascular diseases 
      and leads to a high mortality worldwide. Numerous studies have demonstrated that 
      frequencies of CD4+CD25+Foxp3+ regulatory T cells (Tregs) are reduced in HF 
      patients and properly expanding Tregs attenuates HF progression. Histone 
      deacetylase (HDAC) 9 has been revealed to contribute to several cardiovascular 
      and cerebrovascular diseases. Plenty of studies showed that HDAC9 negatively 
      regulated the number and function of Tregs. Thus, we aim to investigate the 
      expression of HDAC 9 in patients with chronic heart failure (CHF) and the 
      relationship among HDAC9, Tregs and CHF. Our research showed a reduced number of 
      Tregs and an increased expression of HDAC9 mRNA in CHF patients. Patients with 
      CHF were divided into two groups by heart function grade of New York Heart 
      Association (NYHA), we found that the HDAC9 mRNA expression level in NYHA grade 
      II-III group were lower than that in NYHA grade IV group. More importantly, the 
      correlation study suggested that the expression of HDAC9 mRNA was negatively 
      correlated to Tregs frequency and left ventricular ejection fraction (LVEF), 
      whereas positively correlated to larger left ventricular end-diastolic dimension 
      (LVEDD) and B-type natriuretic peptide (BNP) in patients with CHF. The 
      correlation studies also showed a positive correlation between HDAC9 and the 
      severity of CHF. Our research suggests that HDAC9 may be a new indicator for 
      assessing CHF and it may offer a new direction for research of CHF.
FAU - Liao, Ping-Ping
AU  - Liao PP
AD  - Department of Geriatrics, the Affiliated Hospital of Qingdao University, Qingdao, 
      266003, China.
FAU - Liu, Li-Hua
AU  - Liu LH
AD  - Department of Geriatrics, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430022, China.
FAU - Wang, Bin
AU  - Wang B
AD  - Department of Geriatrics, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430022, China.
FAU - Fang, Xin
AU  - Fang X
AD  - Department of Geriatrics, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430022, China.
FAU - Zhou, Shao-Qiong
AU  - Zhou SQ
AD  - Department of Geriatrics, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430022, China.
FAU - Li, Wei
AU  - Li W
AD  - Department of Geriatrics, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430022, China.
FAU - Zhang, Yan-Qing
AU  - Zhang YQ
AD  - Department of Geriatrics, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430022, China.
FAU - Guan, Si-Ming
AU  - Guan SM
AD  - Department of Geriatrics, Union Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan, 430022, China. smguan16@163.com.
LA  - eng
PT  - Journal Article
DEP - 20180430
PL  - China
TA  - Curr Med Sci
JT  - Current medical science
JID - 101729993
RN  - 0 (FOXP3 protein, human)
RN  - 0 (Forkhead Transcription Factors)
RN  - 0 (RNA, Messenger)
RN  - 0 (Repressor Proteins)
RN  - EC 3.5.1.98 (HDAC9 protein, human)
RN  - EC 3.5.1.98 (Histone Deacetylases)
SB  - IM
MH  - Aged
MH  - Chronic Disease
MH  - Female
MH  - Forkhead Transcription Factors/genetics/metabolism
MH  - Heart Failure/*enzymology/genetics/*immunology/physiopathology
MH  - Heart Function Tests
MH  - Histone Deacetylases/genetics/*metabolism
MH  - Humans
MH  - Lymphocyte Count
MH  - Male
MH  - Middle Aged
MH  - RNA, Messenger/genetics/metabolism
MH  - Repressor Proteins/genetics/*metabolism
MH  - T-Lymphocytes, Regulatory/*enzymology
OTO - NOTNLM
OT  - B-type natriuretic peptide
OT  - heart failure
OT  - histone deacetylase 9
OT  - regulatory T cells
EDAT- 2018/08/04 06:00
MHDA- 2018/08/04 06:01
CRDT- 2018/08/04 06:00
PHST- 2017/03/30 00:00 [received]
PHST- 2017/12/06 00:00 [revised]
PHST- 2018/08/04 06:00 [entrez]
PHST- 2018/08/04 06:00 [pubmed]
PHST- 2018/08/04 06:01 [medline]
AID - 10.1007/s11596-018-1866-5 [pii]
AID - 10.1007/s11596-018-1866-5 [doi]
PST - ppublish
SO  - Curr Med Sci. 2018 Apr;38(2):199-203. doi: 10.1007/s11596-018-1866-5. Epub 2018 
      Apr 30.